One of the most critical processes for the long-term management of groundwater resources is Groundwater Potential Zonation (GWPZ). Despite their importance, traditional groundwater studies are costly, difficult, complex, and time-consuming. This study aims to investigate GWPZ mapping for the Al-Qalamoun region, in the Western part of Syria. We combined the Multi-Influence Factor (MIF) and Analytic Hierarchy Process (AHP) methods with the Geographic Information Systems (GIS) to estimate the GWPZ. The weight and score factors of eight factors were used to develop the GWPZ including drainage density, lithology, slope, lineament density, geomorphology, land use/land cover, rainfall, and soil. According to the findings, about 46% and 50.6% of the total area of the Al-Qalamoun region was classified as suitable for groundwater recharge by the AHP and MIF methods, respectively. However, 54% and 49.4% of the area was classified as having poor suitability for groundwater recharge by the AHP and MIF methods, respectively. These areas with poor suitability can be utilized for gathering surface water. The validation of the results showed that the AHP and MIF methods have similar accuracy for the GWPZ; however, the accuracy and results depend on influencing factors and their weights assigned by experts.