Integrated Single-Photon Emission Computed Tomography and Computed Tomography Coronary Angiography for the Assessment of Hemodynamically Significant Coronary Artery Lesions

Rispler, Shmuel; Keidar, Zohar; Ghersin, Eduard; Roguin, Ariel; Soil, Adrian; Dragu, Robert; Litmanovich, Diana; Frenkel, Alex; Aronson, Doron; Engel, Ahuva; Beyar, Rafael; Israel, Ora

doi:10.1016/j.jacc.2006.10.069

Cited by 260 publications

(135 citation statements)

References 24 publications

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“…As a consequence, total radiation dose to the study population was significantly reduced by about 50%, resulting in an average effective radiation dose of 4.8  3.4 mSv per patient. This represents a dose reduction in the range of a power of magnitude compared to earlier studies combining SPECT-MPI with CTCA reaching values of 41 mSv [11]. This is likely to have a major clinical impact, as the balance of harms and benefits is clearly shifted to the favourable end and therefore such combined and accurate non-invasive assessment of CAD will gain importance.…”

Section: Discussionmentioning

confidence: 92%

“…A combination of SPECT-MPI with CTCA has therefore been suggested, as it would overcome the shortcomings of each technique and allow comprehensive anatomical and functional CAD assessment. Although feasibility [8,9] and the potential added clinical value of non-invasive imaging combining MPI with CTCA has been documented [10], the practicability is so far hampered due to a total radiation burden up to 41mSv [11] and long duration of the protocol.…”

Section: Introductionmentioning

confidence: 99%

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Non-invasive assessment of coronary artery disease with CT coronary angiography and SPECT: a novel dose-saving fast-track algorithm

Pazhenkottil

Herzog

Husmann

et al. 2009

Eur J Nucl Med Mol Imaging

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Non-invasive assessment of coronary artery disease with CT coronary angiography and SPECT: a novel dose-saving fast-track algorithm

Pazhenkottil

Herzog

Husmann

et al. 2009

Eur J Nucl Med Mol Imaging

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“…This combined technology allows detection and quantification of the burden of calcified and non-calcified plaques, quantification of vascular activity and endothelial health, identification of flow-limiting coronary stenosis, and potentially identification of high-risk plaques in the coronary artery tree [43]. Combined SPECT/CT and PET/CT systems are today well established in clinical routine imagingwith promising results reported [44][45][46][47][48], although more multicentre trials are needed to validate the diagnostic value of the hybrid imaging modalities. Combined PET/MRI represents another new integrated protocol, however, it is only limited to a few clinical centers for preclinical cardiac imaging with a focus on animal experiments [49,50].…”

Section: Journal Ofmentioning

confidence: 99%

Cardiac Imaging Modalities in the Diagnosis of Coronary Artery Disease

Sun¹

2013

J Clin Exp Cardiolog

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Coronary artery disease is the leading cause of death in advanced countries. Early detection and diagnosis of coronary artery disease plays an important role in the identification of disease severity and prediction of disease outcome, consequently improving patient management. Diagnosis and management of coronary artery disease is increasingly dependent on less-invasive imaging modalities, including coronary CT angiography, cardiac magnetic resonance imaging, cardiac radionuclide imaging such as SPECT and PET modalities. Rapid developments of these imaging modalities have significantly improved the diagnostic performance of each imaging technique with high diagnostic accuracy achieved in both diagnostic and prognostic value in coronary artery disease. This editorial provides an overview of the diagnostic applications of a variety of less-invasive imaging modalities in the diagnosis of coronary artery disease. This special issue of "Arteriosclerotic Vascular Disease: Part II" in the journal of Clinical and Experimental Cardiology will give particular attention to contributions focusing on the clinical applications of these imaging modalities in the arteriosclerotic vascular disease, in particular, coronary artery disease.

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“…To evaluate the diagnostic performance of CTCA combined with MPI for the detection of FRCS, the use of MPI is the accepted reference standard, which has been previously used for the evaluation of the clinical values of hybrid heart imaging devices in patients with known or suspected CAD (21,22).…”

Section: A B C D Ementioning

confidence: 99%

Combined CT angiography and SPECT myocardial perfusion imaging for the detection of functionally relevant coronary stenoses

Shi

Zhang

et al. 2013

Molecular Medicine Reports

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Abstract. The present study aimed to discuss and evaluate the diagnostic performances and incremental clinical values of combined computed tomography coronary angiography (CTCA) and single photon myocardial perfusion imaging (MPI) for the detection of functionally relevant coronary stenoses (FRCS). In total, 54 patients underwent CTCA, MPI and coronary angiography (CAG) within 30 days. The diagnostic performances of CTCA and combined CTCA plus MPI for the detection of significant coronary stenoses (≥50%) were calculated on the patient-or vessel-based levels and included the indices of sensitivity (SN), specificity (SP), positive predictive value (PPV), negative predictive value (NPV) and accuracy (AC). On the patient-based level, the SP, PPV, NPV and AC of CTCA alone or combined with MPI in the detection of FRCS were 90.9 and 90.9, 71.9 and 96.9, 69.0 and 95.2, 92.0 and 93.9 and 79.6 and 94.4%, respectively. On the vessel-based level, the SN, SP, PPV, NPV and AC of CTCA alone or combined with MPI in the detection of FRCS were 90.3 and 90.3, 87.6 and 98.9, 54.9 and 93.3, 98.2 and 98.4 and 88.0 and 97.7%, respectively. The PPV, SP and AC of combined CTCA and MPI in the detection of FRCS were significantly improved compared with CTCA alone (all values, P<0.05). The diagnostic performance of combined CTCA and MPI in the detection of FRCS not only retains a high SN and NPV, but also markedly improves SP, PPV and AC, which should play an incremental and significant role in the decision-making process for the revascularization therapy of coronary artery disease (CAD).

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Integrated Single-Photon Emission Computed Tomography and Computed Tomography Coronary Angiography for the Assessment of Hemodynamically Significant Coronary Artery Lesions

Cited by 260 publications

References 24 publications

Non-invasive assessment of coronary artery disease with CT coronary angiography and SPECT: a novel dose-saving fast-track algorithm

Non-invasive assessment of coronary artery disease with CT coronary angiography and SPECT: a novel dose-saving fast-track algorithm

Cardiac Imaging Modalities in the Diagnosis of Coronary Artery Disease

Combined CT angiography and SPECT myocardial perfusion imaging for the detection of functionally relevant coronary stenoses

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