Integrated view on 17beta-hydroxysteroid dehydrogenases

Origin and diversification of steroids: Co-evolution of enzymes and nuclear receptors

“…Indeed, high affinity binding for E2 is found in vertebrate ERs, rat and mouse alpha-fetoprotein and sex steroid binding globulin [13], as well as in enzymes in yeast [51], which do not have steroid receptors. Another example of convergence is the presence of over ten 17 -hydroxysteroid dehydrogenases that metabolize estrogens and androgens [13][14]52]. …”

“…Further support comes from database searches for orthologs of 17 -HSD-type 1 and 17 -HSD -type 2, which are involved in estrogen synthesis [14][15]25]. There are many 17 -HSD homologs in invertebrates, for which the biological substrate has not been determined [14].…”

“…There are many 17 -HSD homologs in invertebrates, for which the biological substrate has not been determined [14]. However, at this time, orthologs of 17 -HSD-type 1 and 17 -HSD -type 2 have been found only in vertebrates [7].…”

Comparative investigation of thein vitroinhibitory potencies of 13-epimeric estrones and D-secoestrones towards 17β-hydroxysteroid dehydrogenase type 1

“…Structural formulae of the test compounds (1)(2)(3)(4)(5)(6) 51,52 . Our potential anticancer agents were designed on the hormonally inactive D-seco-and/or 13a-estrone core.…”

17β-Hydroxysteroid Dehydrogenase Type 3 Deficiency: Diagnosis, Phenotypic Variability and Molecular Findings

“…17-HSD3 deficiency is rare in Western countries, whereas in areas of high consanguinity, such as among the Gaza Strip Arab population, the incidence of 17-HSD3 deficiency has been reported to be 1 in 100-300 people (Rosler et al, 1996(Rosler et al, , 2006. Of the known cases of 17-HSD3 deficiency, most of the patients have been reported in Europe, Asia, Australia and South America, whereas only 11 cases have been reported in the United States (Mains et al, 2008;Moeller § Adamski, 2009). In a recent study from a gender assessment team in the United States that looked at DSD over a 25-year period, no patient with 17-HSD3 deficiency was diagnosed (Paris et al, 2007).…”