In response to current environmental, social and accessibility challenges in the mobility sector, this research focuses on promoting the development of integrated sustainable regional transport policies, supported by a thorough analysis of their distributed economic impacts. This is fulfilled with the development of a new GIS-supported extension of a comprehensive methodology that is currently used for appraising local transport interventions. To illustrate the inputs and outputs of the expanded approach, a regional case study was simulated, highlighting the potential for this methodology to assist in (1) optimising the financial balance between electrification and modal-shift strategies, (2) anticipating and analysing the multiple economic impacts of multimodal transport services (e.g., Mobility as a Service) and (3) understanding how equal the benefits of these policies are across the region. This research will provide novel contributions to the field of transport research and policy development by introducing a comprehensive methodology that quantifies and maps the distributed economic impacts of regional transport policies. This will, consequently, enable the economic outputs of these policies to be easily visualised, analysed and shared with mobility stakeholders, fostering a better understanding of their urban–rural distribution, and promoting the strategic development of sustainable and equitable regional transport systems.