Integration and viral oncogene expression of human papillomavirus type 16 in oropharyngeal squamous cell carcinoma and gastric cancer

Xu, Qiang; Dong, Haoru; Wang, Zhiyu; Zhang, Pei; Albers, Andreas; Kaufmann, Andreas M.; Zheng, Zhiming; Qian, Xu

doi:10.1002/jmv.28761

Cited by 3 publications

(2 citation statements)

References 51 publications

(140 reference statements)

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“…A meta-analysis has revealed a positive relationship between HPV16 infection and the risk of gastric cancer development. 14 Studies have shown that the occurrence of gastric cancer in Zambia is related to the antibody to the early antigen of EBV, but not to EBV Nuclear Antigen-1. The impact of reactivation of EBV on gastric carcinogenesis in Zambia, where an association between EBV early antigens and HIV-positivity has been demonstrated.…”

Section: Discussionmentioning

confidence: 99%

Unusual presentation of PD-1 inhibitors in people living with HIV with advanced gastric cancer: Case report

Gao,

XU,

Wang

et al. 2024

Int J STD AIDS

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This paper seeks to determine the effect of combination anti-PD-1 and antiretroviral therapy (ART) on people living with HIV (PLWH) with advanced gastric cancer. In our case, a PLWH with recurrent locally advanced gastric cancer was treated with anti-PD-1 inhibitor and ART. A significant reduction in tumor lesions (as demonstrated by contrast-enhanced CT imaging) and a better quality of life were achieved following treatment. There have been limited studies on the treatment of PLWH with advanced gastric cancer. Chemotherapy is most often used, however, with unsatisfactory outcomes. to date, there have been no published reports on the use of PD-1 inhibitors in PLWH with advanced gastric cancer. Our report provides a valuable reference for future management of such patients.

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Section: Discussionmentioning

confidence: 99%

Unusual presentation of PD-1 inhibitors in people living with HIV with advanced gastric cancer: Case report

Gao,

XU,

Wang

et al. 2024

Int J STD AIDS

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show abstract

“…Interestingly, there were significant variations in HPV status between Chinese and non-Chinese studies. Notably, HPV positivity was 1.43-times higher in Chinese GC patients than in non-Chinese patients, indicating a potential association between HPV infection and GC development in the Chinese population [202]. However, another study did not detect HPV DNA in the gastric mucosa tissue of GC patients in China [203].…”

Section: Clinical Significance Of Hpv In Gcmentioning

confidence: 96%

Exploring the Microbiome in Gastric Cancer: Assessing Potential Implications and Contextualizing Microorganisms beyond H. pylori and Epstein-Barr Virus

Shin,

Xie,

Chen

et al. 2023

Cancers

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While previous research has primarily focused on the impact of H. pylori and Epstein-Barr virus (EBV), emerging evidence suggests that other microbial influences, including viral and fungal infections, may also contribute to gastric cancer (GC) development. The intricate interactions between these microbes and the host’s immune response provide a more comprehensive understanding of gastric cancer pathogenesis, diagnosis, and treatment. The review highlights the roles of established players such as H. pylori and EBV and the potential impacts of gut bacteria, mainly Lactobacillus, Streptococcus, hepatitis B virus, hepatitis C virus, and fungi such as Candida albicans. Advanced sequencing technologies offer unprecedented insights into the complexities of the gastric microbiome, from microbial diversity to potential diagnostic applications. Furthermore, the review highlights the potential for advanced GC diagnosis and therapies through a better understanding of the gut microbiome.

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De novo generation of SARS-CoV-2 antibody CDRH3 with a pre-trained generative large language model

He,

Guan

et al. 2024

Nat Commun

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Artificial Intelligence (AI) techniques have made great advances in assisting antibody design. However, antibody design still heavily relies on isolating antigen-specific antibodies from serum, which is a resource-intensive and time-consuming process. To address this issue, we propose a Pre-trained Antibody generative large Language Model (PALM-H3) for the de novo generation of artificial antibodies heavy chain complementarity-determining region 3 (CDRH3) with desired antigen-binding specificity, reducing the reliance on natural antibodies. We also build a high-precision model antigen-antibody binder (A2binder) that pairs antigen epitope sequences with antibody sequences to predict binding specificity and affinity. PALM-H3-generated antibodies exhibit binding ability to SARS-CoV-2 antigens, including the emerging XBB variant, as confirmed through in-silico analysis and in-vitro assays. The in-vitro assays validate that PALM-H3-generated antibodies achieve high binding affinity and potent neutralization capability against spike proteins of SARS-CoV-2 wild-type, Alpha, Delta, and the emerging XBB variant. Meanwhile, A2binder demonstrates exceptional predictive performance on binding specificity for various epitopes and variants. Furthermore, by incorporating the attention mechanism inherent in the Roformer architecture into the PALM-H3 model, we improve its interpretability, providing crucial insights into the fundamental principles of antibody design.

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Integration and viral oncogene expression of human papillomavirus type 16 in oropharyngeal squamous cell carcinoma and gastric cancer

Cited by 3 publications

References 51 publications

Unusual presentation of PD-1 inhibitors in people living with HIV with advanced gastric cancer: Case report

Unusual presentation of PD-1 inhibitors in people living with HIV with advanced gastric cancer: Case report

Exploring the Microbiome in Gastric Cancer: Assessing Potential Implications and Contextualizing Microorganisms beyond H. pylori and Epstein-Barr Virus

De novo generation of SARS-CoV-2 antibody CDRH3 with a pre-trained generative large language model

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