Integration of microfluidic sample preparation with PCR detection to investigate the effects of simultaneous DNA-Inhibitor separation and DNA solution exchange

Microparticle manipulation in viscoelastic flows inside curvilinear microchannels: a thorough fundamental study with application to simultaneous particle sorting and washing

“…Utilizing this estimation, we designed high throughput particle washing devices, where the target microparticles were transferred from source water into a clean buffer with high efficiencies (490%). 20,49 Ducloue ´et al, 50 Yoon et al 51,52 and others [53][54][55][56] numerically investigated the effect of De number and fluid viscosity on the secondary vortices of shear-thinning fluids in curved microchannels. We experimentally studied the effects of channel geometry and fluid properties on the Dean velocity of shearthinning PEO in water solutions 57 and shear-thickening SiO 2 nanofluids 58 in curvilinear microchannels.…”

“…Utilizing this estimation, we designed high throughput particle washing devices, where the target microparticles were transferred from source water into a clean buffer with high efficiencies (>90%). 20,49…”

“…It is worth mentioning that the variable radius of curvature in a spiral microchannel, despite being effective in providing channel length for particle sorting, makes it extremely difficult to manipulate the fluid position laterally, as opposed to curved microchannels with a constant radius that can provide control over both particle focusing and fluid lateral position. 19,20 Despite the reports on the Dean flow velocity of Newtonian fluids, many food and biological fluids such as raw milk and blood usually demonstrate non-Newtonian behaviors. In non-Newtonian fluids, the applied shear stress alters the fluid rheological characteristics.…”

“…It is worth mentioning that the variable radius of curvature in a spiral microchannel, despite being effective in providing channel length for particle sorting, makes it extremely difficult to manipulate the fluid position laterally, as opposed to curved microchannels with a constant radius that can provide control over both particle focusing and fluid lateral position. 19,20…”

Experimental investigation of microparticle focusing in SiO2 nanofluids inside curvilinear microchannels

“…Here, s represents the channel largest dimension (s = max (w,h), with w and h representing the channel width and height, respectively), and 𝜗 = 𝜇 𝜌 ⁄ is the fluid kinematic viscosity. Later on, this estimation of VDe was used to design a high throughput washing process in which microparticles were separated with high efficiencies (> 90%) and were transferred into a clean buffer (Bayat and Rezai, 2018;Nikdoost et al, 2021).…”