Integration of transcriptomics, metabolomics, and lipidomics reveals the mechanisms of doxorubicin-induced inflammatory responses and myocardial dysfunction in mice

Tan, Xin; Zhang, Rongyi; Lan, Meide; Wei, Cong; Wang, Hao; Guo, Junsong; Zhao, Xuemei; Xu, Hui; Deng, Ping; Pi, Huifeng; Yu, Zhengping; Yue, Rongchuan; Hu, Houxiang

doi:10.1016/j.biopha.2023.114733

Cited by 8 publications

(1 citation statement)

References 54 publications

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“…Its application in revealing the mechanisms of action of drugs or food has proven highly valuable. 23 The integration of metabolomics and 16S rRNA sequencing technology has demonstrated that the mechanism in which food can improve intestinal peristalsis and stress is through the regulation of structure and abundance of intestinal flora, as well as the composition of plasma metabolites, and finally alleviating intestinal diseases by regulating the central or peripheral nerves.…”

Section: Introductionmentioning

confidence: 99%

Integrated metabolic profiles and microbial communities to reveal the beneficial effect of red pitaya on early constipation

Zhao,

Meng,

Sun

et al. 2024

Food Funct.

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Section: Introductionmentioning

confidence: 99%

Integrated metabolic profiles and microbial communities to reveal the beneficial effect of red pitaya on early constipation

Zhao,

Meng,

Sun

et al. 2024

Food Funct.

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Ferroptosis: Latest evidence and perspectives on plant‐derived natural active compounds mitigating doxorubicin‐induced cardiotoxicity

Wang,

Liu

et al. 2024

J of Applied Toxicology

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Doxorubicin (DOX) is a chemotherapy drug widely used in clinical settings, acting as a first‐line treatment for various malignant tumors. However, its use is greatly limited by the cardiotoxicity it induces, including doxorubicin‐induced cardiomyopathy (DIC). The mechanisms behind DIC are not fully understood, but its potential biological mechanisms are thought to include oxidative stress, inflammation, energy metabolism disorders, mitochondrial damage, autophagy, apoptosis, and ferroptosis. Recent studies have shown that cardiac injury induced by DOX is closely related to ferroptosis. Due to their high efficacy, availability, and low side effects, natural medicine treatments hold strong clinical potential. Currently, natural medicines have been shown to mitigate DOX‐induced ferroptosis and ease DIC through various functions such as antioxidation, iron ion homeostasis correction, lipid metabolism regulation, and mitochondrial function improvement. Therefore, this review summarizes the mechanisms of ferroptosis in DIC and the regulation by natural plant products, with the expectation of providing a reference for future research and development of inhibitors targeting ferroptosis in DIC.This review explores the mechanisms of ferroptosis in doxorubicin‐induced cardiomyopathy (DIC) and summarizes how natural plant products can alleviate DIC by inhibiting ferroptosis through reducing oxidative stress, correcting iron ion homeostasis, regulating lipid metabolism, and improving mitochondrial function.

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From Data to Cure: A Comprehensive Exploration of Multi-omics Data Analysis for Targeted Therapies

Mukherjee,

Abraham,

Singh

et al. 2024

Mol Biotechnol

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In the dynamic landscape of targeted therapeutics, drug discovery has pivoted towards understanding underlying disease mechanisms, placing a strong emphasis on molecular perturbations and target identification. This paradigm shift, crucial for drug discovery, is underpinned by big data, a transformative force in the current era. Omics data, characterized by its heterogeneity and enormity, has ushered biological and biomedical research into the big data domain. Acknowledging the significance of integrating diverse omics data strata, known as multi-omics studies, researchers delve into the intricate interrelationships among various omics layers. This review navigates the expansive omics landscape, showcasing tailored assays for each molecular layer through genomes to metabolomes. The sheer volume of data generated necessitates sophisticated informatics techniques, with machine-learning (ML) algorithms emerging as robust tools. These datasets not only refine disease classification but also enhance diagnostics and foster the development of targeted therapeutic strategies. Through the integration of high-throughput data, the review focuses on targeting and modeling multiple disease-regulated networks, validating interactions with multiple targets, and enhancing therapeutic potential using network pharmacology approaches. Ultimately, this exploration aims to illuminate the transformative impact of multi-omics in the big data era, shaping the future of biological research.

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Integration of transcriptomics, metabolomics, and lipidomics reveals the mechanisms of doxorubicin-induced inflammatory responses and myocardial dysfunction in mice

Cited by 8 publications

References 54 publications

Integrated metabolic profiles and microbial communities to reveal the beneficial effect of red pitaya on early constipation

Integrated metabolic profiles and microbial communities to reveal the beneficial effect of red pitaya on early constipation

Ferroptosis: Latest evidence and perspectives on plant‐derived natural active compounds mitigating doxorubicin‐induced cardiotoxicity

From Data to Cure: A Comprehensive Exploration of Multi-omics Data Analysis for Targeted Therapies

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