2017
DOI: 10.1371/journal.pone.0169164
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Integrative Analysis of Immunological Data to Explore Chronic Immune T-Cell Activation in Successfully Treated HIV Patients

Abstract: ObjectivesTo unravel the complex relationships between cytomegalovirus-induced-, autoimmune-induced responses, microbial translocation and chronic immune activation (CIA) in successfully treated HIV-infected patients and to explore the mediating role of alpha-interferon in these processes.DesignCross-sectional study nested in the ANRS CO3 Aquitaine Cohort, a prospective hospital-based cohort of HIV-1-infected patients in South-Western France.MethodsPatients initiated antiretroviral therapy between 2005 and 200… Show more

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Cited by 5 publications
(5 citation statements)
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“…In previous studies, increased CMV-specific CD8+ T-cell responses has been associated with higher proportions of activated CD8+ T-cells (HLA-DR+/CD38+/CD8+) in PLWHIV on cART 15 , 22 . In addition, a high CMV IgG response has been associated with monocyte activation (sCD14) 20 , 41 .…”
Section: Discussionmentioning
confidence: 82%
See 1 more Smart Citation
“…In previous studies, increased CMV-specific CD8+ T-cell responses has been associated with higher proportions of activated CD8+ T-cells (HLA-DR+/CD38+/CD8+) in PLWHIV on cART 15 , 22 . In addition, a high CMV IgG response has been associated with monocyte activation (sCD14) 20 , 41 .…”
Section: Discussionmentioning
confidence: 82%
“…However, we found an association between increased CMV-specific CD4+ T-cell responses and higher proportions of activated CD8+ T-cells. Notably, previous studies did not investigate CMV-specific CD4+ T-cell responses 15 , 22 .…”
Section: Discussionmentioning
confidence: 99%
“…While this limits the scope of the current study, it nevertheless provides sufficient data for proof of concept that bacterial genera, species and strain discrimination using the host immune response is possible; (ii) the choice of bacterial collection within a species could be better defined and include E. coli strains from bacteraemia patients; (iii) the relatively small number of blood donors (n = 5) is sufficient for proof of concept but does not describe the variation in host response in a healthy population [1]. Finally, it is clear that more advanced multivariate analysis and modelling approaches used to determine cytokine interdependencies and networks may also provide a rational next step for biomarker discovery [103][104][105][106].…”
Section: Discussionmentioning
confidence: 99%
“…Picat et al. ( 9 ) used ODEs to study the effects of IL-7 injections on T-cell dynamics in HIV-infected patients. Picat et al.…”
Section: Introductionmentioning
confidence: 99%
“…Picat et al. ( 9 ) used machine learning to study chronic immune T-cell activation in successfully treated HIV patients. Both studies used mathematical modeling and data analysis techniques to investigate immune responses in humans and have potential implications for the treatment of HIV infection and other immune-related conditions.…”
Section: Introductionmentioning
confidence: 99%