Integrative network analysis revealed molecular mechanisms of urine urea output in lactating dairy cows: Potential solutions to reduce environmental nitrate contamination

Wang, Diming; Cai, Jie; Wang, Bing; Ding, Shengsen; Guan, Le Luo; Liu, Jianxin

doi:10.1016/j.ygeno.2021.03.024

Cited by 3 publications

(1 citation statement)

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“…Keratin 17(KRT17) located on BTA19:41.83-41.84 Mb plays a role in the regulation of urine urea nitrogen yield and urine volume, while during milk protein synthesis Apolipoprotein E (APOE) located on BTA18:52.63-52.64 Mb improved ribosome biosynthesis resulting in less nitrogen being excreted as urine urea as previously detected by Wang et al (2021). Other genes include Alpha-2-macroglobulin like 1 (A2ML1 located on BTA5:101.04-101.09 Mb) and 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2 located on BTA3: 23.53-23.56 Mb) were found to increase urine urea nitrogen and also previously detected by Wang et al (2021). Previous studies observed that Nguni cattle were more capable of maintaining their body weight during winter than other breeds.…”

Section: Discussionmentioning

confidence: 60%

Selection Signatures in South African Nguni and Bonsmara Cattle Populations Reveal Genes Relating to Environmental Adaptation

et al. 2022

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Climate change is a major influencing factor in beef production. The greenhouse gases produced from livestock production systems contribute to the overall greenhouse gas emissions. The aim of this study was to identify selection signatures within and between Nguni and Bonsmara cattle in relation to production and adaptation. For this purpose, genomic 150 K single nucleotide polymorphism data from Nguni (n = 231) and Bonsmara (n = 252) cattle in South Africa were used. Extended haplotype homozygosity (EHH) based analysis was executed within each population using integrated haplotype score (iHS). The R package rehh was used for detecting selection signatures across the two populations with cross population EHH (XP-EHH). Total of 121 regions of selection signatures were detected (p < 0.0001) in the Bonsmara and Nguni populations. Several genes relating to DNA methylation, heat stress, feed efficiency and nitrogen metabolism were detected within and between each population. These regions also included QTLs associated with residual feed intake, residual gain, carcass weight, stature and body weight in the Bonsmara, while QTLs associated with conception rate, shear force, tenderness score, juiciness, temperament, heat tolerance, feed efficiency and age at puberty were identified in Nguni. Based on the results of the study it is recommended that the Nguni and Bonsmara be utilized in crossbreeding programs as they have beneficial traits that may allow them to perform better in the presence of climate change. Results of this study coincide with Nguni and Bonsmara breed characteristics and performance, and furthermore support informative crossbreeding programs to enhance livestock productivity in South Africa.

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Section: Discussionmentioning

confidence: 60%