Integrin adhesion in brain assembly: From molecular structure to neuropsychiatric disorders

Jaudon, Fanny; Thalhammer, Agnes; Cingolani, Lorenzo A.

doi:10.1111/ejn.14859

Cited by 43 publications

(49 citation statements)

References 187 publications

(270 reference statements)

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“…Moreover, the integrin-mediated cell interactions are tightly regulated by plasminogen activators like SERPINE1 (74) that is significantly upregulated in the fibroblasts of our patient. Neurological impairments can result from deregulation of cell-cell or cell-substrate adhesion (reviewed in (69,75).…”

Section: Csde1 and Id-asd -mentioning

confidence: 99%

Wnt/β-catenin pathway and cell adhesion deregulation in CSDE1-related intellectual disability and autism spectrum disorders

et al. 2021

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Among the genetic factors playing a key role in the etiology of intellectual disabilities (ID) and autism spectrum disorders (ASD), several encode RNA binding proteins (RBPs). In this study, we deciphered the molecular and cellular bases of ID-ASD in a patient followed from birth to the age of 21, in whom we identified a de novo CSDE1 (Cold Shock Domain-containing E1) nonsense variation. CSDE1 encodes an RBP that regulates multiple cellular pathways by monitoring the translation and abundance of target transcripts. Analyses performed on the patient's primary fibroblasts showed that the identified CSDE1 variation leads to haploinsufficiency. We identified through RNA-seq assays the Wnt/β-catenin signaling and cellular adhesion as two major deregulated pathways. These results were further confirmed by functional studies involving Wnt-specific luciferase and substrate adhesion assays. Additional data support a disease model involving APC Down-Regulated-1 (APCDD1) and cadherin-2 (CDH2), two components of the Wnt/β-catenin pathway, CDH2 being also pivotal for cellular adhesion. Our study, which relies on both the deep phenotyping and long-term follow-up of a patient with CSDE1 haploinsufficiency and on ex-vivo studies, sheds new light on the CSDE1dependent deregulated pathways in ID-ASD.

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Section: Csde1 and Id-asd -mentioning

confidence: 99%

Wnt/β-catenin pathway and cell adhesion deregulation in CSDE1-related intellectual disability and autism spectrum disorders

et al. 2021

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“…Besides extracellular proteolysis, signaling triggered via receptors for ECM components, such as integrins, is a key topic to understand the role of ECM in the etiology of brain disorders. The review by Fanny Jaudon and co‐workers focuses on common mechanisms and signaling pathways mediated by integrins, such as regulation of trafficking and activities of AMPA and NMDA subtypes of glutamate receptors and activation of microglia, attempting to bring together data from studies on the genetics and molecular structure of integrins with those on synaptic physiology and brain pathology (Jaudon et al., 2020). Importantly, diverse integrin‐targeting strategies have been developed in the cancer field and for non‐neuronal tissues.…”

mentioning

confidence: 99%

Brain extracellular matrix: An upcoming target in neurological and psychiatric disorders

Dityatev

Seidenbecher

Morawski

2021

Eur J of Neuroscience

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“…Formation, maturation, and function of synaptic connections require the engagement of several integrins. Presynaptic β1 integrins serve as counter-receptors for postsynaptic intercellular adhesion molecule-5 (ICAM-5; aka telencephalin) [ 58 ]. Integrin beta-1 is mainly expressed in normal cells and in tumor-associated cells, where they control various developing processes, including angiogenesis, tumor progression, apoptosis, and metastasis [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

A SARS-CoV-2 –human metalloproteome interaction map

Chasapis

Georgiopoulou

Perlepes

et al. 2021

Journal of Inorganic Biochemistry

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The recent pandemic caused by the novel coronavirus resulted in the greatest global health crisis since the Spanish flu pandemic of 1918. There is limited knowledge of whether SARS-CoV-2 is physically associated with human metalloproteins. Recently, high-confidence, experimentally supported protein-protein interactions between SARS-CoV-2 and human proteins were reported. In this work, 58 metalloproteins among these human targets have been identified by a structure-based approach. This study reveals that most human metalloproteins interact with the recently discovered SARS-CoV-2 orf8 protein, whose antibodies are one of the principal markers of SARS-CoV-2 infections. Furthermore, this work provides sufficient evidence to conclude that Zn 2+ plays an important role in the interplay between the novel coronavirus and humans. First, the content of Zn-binding proteins in the involved human metalloproteome is significantly higher than that of the other metal ions. Second, a molecular linkage between the identified human Zn-binding proteome with underlying medical conditions that might increase the risk of severe illness from the SARS-CoV-2 virus has been found. Likely perturbations of host cellular metal homeostasis by SARS-CoV-2 infection are highlighted.

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Integrin adhesion in brain assembly: From molecular structure to neuropsychiatric disorders

Cited by 43 publications

References 187 publications

Wnt/β-catenin pathway and cell adhesion deregulation in CSDE1-related intellectual disability and autism spectrum disorders

Wnt/β-catenin pathway and cell adhesion deregulation in CSDE1-related intellectual disability and autism spectrum disorders

Brain extracellular matrix: An upcoming target in neurological and psychiatric disorders

A SARS-CoV-2 –human metalloproteome interaction map

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