Integrin β₂-Chain (CD18) Over-Expression on CD4⁺ T Cells and Monocytes after Ischemia/Reperfusion in Patients Undergoing Primary Percutaneous Revascularization

Abstract

beta2-integrin subunit (CD18) plays an essential role in leukocyte recruitment and adhesion in sites of endothelial injury. We analyzed the surface expression of CD18 on T lymphocytes and monocytes in a series of patients presenting acute coronary syndrome (ACS) who underwent primary percutaneous intervention (PCI) for coronary artery revascularization. We found that basal CD18 expression on peripheral blood-derived CD4+ (but not CD8+) T lymphocytes was significantly increased in ACS patients as compared with age-matched healthy volunteers. During primary PCI, a significant increase in CD18 molecule density was detected immediately after balloon deflation (reperfusion) on both CD4+ T cells and monocytes obtained from the right atrium (RT) as compared with basal values. These data suggest that upregulation of CD18 molecules plays an important role in local recruitment of CD4+ T cells and monocytes to the site of endothelial damage after ischemia/reperfusion, therefore being responsible, at least in part, for the inflammatory-mediated complications associated with primary PCI.

Sphingolipid Microdomains Mediate CD38 Internalization: Topography of the Endocytosis

“…This means that sorting into MVBs can determine both the delivery of transmembrane proteins to lysosomes and the extracellular space, and also the ability of endocytosed receptors to transmit signals. Finally, in accordance with recent perspectives (36)(37)(38)(39)(40) showing the importance of endocytic processes in regulating the activity and distribution of receptormediate signals we demonstrated that CD38 cell surface signalling is down-regulated by endocytosis but, persisting at MVBs level, might have a positive role in the intracellular signalling.…”

Effect of a 180 mg ticagrelor loading dose on myocardial necrosis in patients undergoing elective percutaneous coronary intervention: A preliminary study

“…Myocardial necrosis, www.cardiologyjournal.org which can range from a minor elevation of cardiac enzymes to a large infarct, is the most common complication following PCI. Microembolization of plague debris during PCI procedure has been proposed as the most likely cause of myocardial necrosis [18], and myocardial necrosis could also be associated with ischemia and reperfusion injury after stent implantation and sudden blood supply of ischemic myocardial tissues [19]. Cardiac troponins are a more sensitive marker than CK-MB in detecting minor degrees of myocardial necrosis following PCI [20,21].…”

Inhibition of MCP-1 and MIP-2 Chemokines in Murine Trichinellosis: Effect of the Anti-Inflammatory Compound L-Mimosine

“…The modulation of chemokines by mimosine can henceforth affect the outcome of the inflammatory response (44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60), the products of which are also important for initiating tissue repair, by chemoattracting immune cells into a wound site. Our study contributes to a better understanding of the mechanism by which blood cells profoundly affect inflammatory responses in vivo and suggests that the inhibitor ofMCP-1 and MIP-2, L-mimosine, may have its effects on inflammatory conditions produced by parasites.…”