Integrins and Cell Adhesion Molecules

Correlação entre mediadores inflamatórios na secreção nasofaríngea e no soro de crianças com infecção do trato respiratório inferior por vírus sincicial respiratório e a gravidade da doença

“…(3)(4)(5) In vitro studies and studies of children with RSV infection have demonstrated that the epithelial cells of the airways and the alveolar macrophages produce various inflammatory mediators, such as prostaglandins, leukotrienes, cytokines (TNF-α, IFN-, IL-1, IL-2, IL-6 and IL-10), chemokines (IL-8 and CCL5), soluble intercellular adhesion molecule type 1 (sICAM-1) and growth factors. (6,7) Lower concentrations of Th1 cytokines, such as TNF-α, and higher concentrations of Th2 cytokines, such as IL-6, have been described in the acute phase of severe disease caused by RSV. (8) The cytokines TNF-α and IL-1, synthesized by respiratory epithelial cells infected with RSV, activate the cascade of pro-inflammatory mediators, as well as promoting recruitment, migration and adhesion of specific types of leukocytes (monocytes, neutrophils and T lymphocytes) to the tissues affected by the viral activity, with subsequent degranulation and an increase in tissue damage.…”