2014
DOI: 10.1161/circresaha.114.301275
|View full text |Cite
|
Sign up to set email alerts
|

Integrins and Integrin-Associated Proteins in the Cardiac Myocyte

Abstract: Integrins are heterodimeric, transmembrane receptors that are expressed in all cells, including those in the heart. They participate in multiple critical cellular processes including adhesion, extracellular matrix organization, signaling, survival, and proliferation. Particularly relevant for a contracting muscle cell, integrins are mechanotransducers, translating mechanical to biochemical information. While it is likely that cardiovascular clinicians and scientists have highest recognition of integrins in the… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

3
170
0
3

Year Published

2016
2016
2020
2020

Publication Types

Select...
8
1

Relationship

1
8

Authors

Journals

citations
Cited by 180 publications
(176 citation statements)
references
References 160 publications
3
170
0
3
Order By: Relevance
“…A number of intracellular proteins and membrane receptors have been found to be crucial for organizing this interactive arrangement between the intracellular CM environment and the surrounding ECM. The integrin family of adhesion receptors are key proteins operative in this response (4). Integrins are a large family of 18 α-subunits and 8 β-subunits, which heterodimerize noncovalently, forming over 24 unique transmembrane receptors on virtually all cells, including CMs.…”
mentioning
confidence: 99%
“…A number of intracellular proteins and membrane receptors have been found to be crucial for organizing this interactive arrangement between the intracellular CM environment and the surrounding ECM. The integrin family of adhesion receptors are key proteins operative in this response (4). Integrins are a large family of 18 α-subunits and 8 β-subunits, which heterodimerize noncovalently, forming over 24 unique transmembrane receptors on virtually all cells, including CMs.…”
mentioning
confidence: 99%
“…β1-integrin is the main β subunit in the heart and acts as a critical mechanotransducer, transmitting physical stress signals from the extracellular matrix into the cell. 41,42 Results have demonstrated that β1-integrin is a main sensor that affects the cardiac specification and differentiation of stem cells in the heart. 43,44 Our recent study shows that the β1-integrin-mediated signaling pathway modulates the enhanced assembly of electrical and mechanical junctions in cultured CMs due to CNTs.…”
Section: Discussionmentioning
confidence: 99%
“…5,32 Immunohistochemical staining and quantification (Figure 4Ai and 4Aii) and Western blotting (Figure 4Bi and 4Bii) showed increased integrin β1 levels after pressure overload in both genotypes. However, a significantly higher level of integrin β1 was detected in hearts with reduced ADAM17 (ADAM17 f/f /Cre) compared with ADAM17 f/f hearts post-TAC (Figure 4Bi and 4Bii).…”
Section: Tac Micementioning
confidence: 98%