Intellectual and Visuo-spatial Assessment in Long-Term Pediatric Liver Transplantation for Biliary Atresia

Yssaad-Fesselier, Rosa; Lion‐François, Laurence; Herbillon, Vania; Rivet, Christine; Brunet, Anne-Sophie; Yantren, Habiba; Bost, Muriel; Lachaux, Alain

doi:10.1097/tp.0b013e3181a27b58

Cited by 6 publications

(8 citation statements)

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“…No difficulties with attention were evident, neither in the neurocognitive evaluation nor in the parental reports of executive functions including attention in the FTF. In addition, processing speed on timed tasks (Visuomotor Precision and Speeded Naming) did not differ between the LTx children and the control group (data not shown), and LTx children seem to have normal processing speed (8).…”

Section: Discussionmentioning

confidence: 92%

“…Both scores have, however, been within the norm (7). Lower scores in memory and learning compared with children with cystic fibrosis (7, 10) and working memory in the borderline range (8) have appeared in reports. In our study, parents reported poorer memory function and learning, but our patients did not differ from healthy controls on standardized tests of either verbal or visual memory.…”

Section: Discussionmentioning

confidence: 99%

“…Most studies have assessed global intelligence alone, and few studies have included one or more specific neurocognitive domains. These have reported deficits in working memory (8), expressive and receptive language (7), visuospatial performance (8, 10), and sequential processing of information (5). On tests of achievement, 26% of school‐aged children with LTx may have learning difficulties on the basis of a discrepancy between IQ and achievement scores (4).…”

mentioning

confidence: 99%

“…The cognitive outcome of children undergoing LTx has, in general, been in the low average to average range. This includes both infants with early onset liver disease (mainly biliary atresia) and children with later ages of disease onset (1)(2)(3)(4)(5)(6)(7)(8). Pre-Tx developmental level may deteriorate shortly after LTx but recovers to pre-Tx levels in long-term follow-up (1,2).…”

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confidence: 99%

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Visuospatial impairment in children and adolescents after liver transplantation

Haavisto

Korkman

Törmänen

et al. 2010

Pediatric Transplantation

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A minority of children with liver transplants exhibit significant delay in global intelligence; others have specific learning disabilities. More specific data on neurocognitive strengths and weaknesses are lacking. Eighteen children aged 7-16 yr, who had undergone LTx in Finland participated in the study. They were assessed on an average 7.6 (s.d. 4.5, range 1.0-15.0) years post-operatively at a mean age of 11.8 (s.d. 3.1, range 7.2-16.1). A standardized test of intelligence (WISC-III), a neuropsychological test battery (NEPSY-II), and a parental questionnaire on the child's development (FTF) were administered. The neuropsychological test profile of the LTx group was compared with that of a matched control group of healthy children. The LTx children achieved on an average normal FSIQ 94.0 and VIQ 99.6. Their Performance Intelligence Quotient (PIQ 88.9, p=0.043) was, however, significantly lower than the population mean. On neuropsychological assessment, the LTx children scored generally lower than the control group (p=0.004), a difference significant in sub-tests assessing visuospatial and visuoconstructive functions and social perception. No differences emerged in sub-tests of attention and executive functions, memory and learning, or language functions. LTx children are at increased risk for impairment in the visuospatial domain.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Visuospatial impairment in children and adolescents after liver transplantation

Haavisto

Korkman

Törmänen

et al. 2010

Pediatric Transplantation

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“…The present sample displayed significantly longer reaction times and significantly more omissions and errors compared with the norm with 38% scoring below the normal range. Another study found that children with biliary atresia performed below average at working memory index score of the WISC-IV after transplantation (40).…”

Section: Discussionmentioning

confidence: 99%

Attention and Executive Functioning Deficits in Liver-Transplanted Children

et al. 2010

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Results provide evidence suggesting that liver-transplanted children are at risk of developmental deficits regarding attention and executive functioning. Especially intrinsic alertness and working memory performance seem to be insufficient. This might result in deficient initiating, sustaining, and controlling of action. In summary, results demonstrate the need for an early and comprehensive developmental screening after pediatric liver transplantation.

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Neurodevelopment and Health Related Quality of Life of the Transplanted Child

Woolfson

2019

Pediatric Hepatology and Liver Transplantation

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Intellectual and Visuo-spatial Assessment in Long-Term Pediatric Liver Transplantation for Biliary Atresia

Cited by 6 publications

References 4 publications

Visuospatial impairment in children and adolescents after liver transplantation

Visuospatial impairment in children and adolescents after liver transplantation

Attention and Executive Functioning Deficits in Liver-Transplanted Children

Neurodevelopment and Health Related Quality of Life of the Transplanted Child

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