Intelligent and spatiotemporal drug release based on multifunctional nanoparticle-integrated dissolving microneedle system for synergetic chemo-photothermal therapy to eradicate melanoma

Zhao, Yiting; Zhou, Yao; Yang, Dan; Gao, Xinyi; Wen, Ting; Fu, Jintao; Wen, Xinguo; Quan, Guilan; Pan, Xin; Wu, Chuanbin

doi:10.1016/j.actbio.2021.09.009

Cited by 58 publications

(33 citation statements)

References 50 publications

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“…We found that the pore size of the hydrogel was significantly smaller due to the increase in the amount of the pre-solution post concentration, and the increase in the cross-linking density. Based on the above research and referring to the previous MNs preparation methods, we used the mold method, a commonly used MNs preparation method, to prepare MNs [ 42 , 43 ]. Through scanning electron microscopy, we found that the obtained MNs had excellent morphology for the effectively penetration of the skin and the steady release of drugs and exos for diabetic skin repair.…”

Section: Discussionmentioning

confidence: 99%

GelMA/PEGDA microneedles patch loaded with HUVECs-derived exosomes and Tazarotene promote diabetic wound healing

et al. 2022

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Clinical work and research on diabetic wound repair remain challenging globally. Although various conventional wound dressings have been continuously developed, the efficacy is unsatisfactory. The effect of drug delivery is limited by the depth of penetration. The sustained release of biomolecules from biological wound dressings is a promising treatment approach to wound healing. An assortment of cell-derived exosomes (exos) have been proved to be instrumental in tissue regeneration, and researchers are dedicated to developing biomolecules carriers with unique properties. Herein, we reported a methacrylate gelatin (GelMA) microneedles (MNs) patch to achieve transdermal and controlled release of exos and tazarotene. Our MNs patch comprising GelMA/PEGDA hydrogel has distinctive biological features that maintain the biological activity of exos and drugs in vitro. Additionally, its unique physical structure prevents it from being tightly attached to the skin of the wound, it promotes cell migration, angiogenesis by slowly releasing exos and tazarotene in the deep layer of the skin. The full-thickness cutaneous wound on a diabetic mouse model was carried out to demonstrate the therapeutic effects of GelMA/PEGDA@T + exos MNs patch. As a result, our GelMA/PEGDA@T + exos MNs patch presents a potentially valuable method for repairing diabetic wound in clinical applications. Graphic Abstract

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Section: Discussionmentioning

confidence: 99%

GelMA/PEGDA microneedles patch loaded with HUVECs-derived exosomes and Tazarotene promote diabetic wound healing

et al. 2022

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“…HA itself could target CD44, and ZIF-8, modified by HA, could specifically gift down cellular uptake to enhance therapeutic efficacy. The MNs could be loaded with multiple drugs simultaneously, improving the specificity of targeting tumors and overcoming the limitation of monotherapy [ 105 ].…”

Section: Polysaccharide Based Drug Delivery For Diseases Therapeuticsmentioning

confidence: 99%

“… Schematic representation of ( a ) the preparation of CPT-CuS-ZIF-8@HA and ( b ) multifunctional nanoparticle-integrated DMNs for transdermal drug delivery, smart drug release, targeted delivery, and synergistic chemotherapy-photothermal therapy in melanoma [ 105 ]. Reproduced with permission from Yiting Zhao, Acta Biomaterialia; published by Elsevier, 2021.…”

Section: Figurementioning

confidence: 99%

Polysaccharide-Based Transdermal Drug Delivery

Xiang

Zhang

et al. 2022

Pharmaceuticals

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Materials derived from natural plants and animals have great potential for transdermal drug delivery. Polysaccharides are widely derived from marine, herbal, and microbial sources. Compared with synthetic polymers, polysaccharides have the advantages of non-toxicity and biodegradability, ease of modification, biocompatibility, targeting, and antibacterial properties. Currently, polysaccharide-based transdermal drug delivery vehicles, such as hydrogel, film, microneedle (MN), and tissue scaffolds are being developed. The addition of polysaccharides allows these vehicles to exhibit better-swelling properties, mechanical strength, tensile strength, etc. Due to the stratum corneum’s resistance, the transdermal drug delivery system cannot deliver drugs as efficiently as desired. The charge and hydration of polysaccharides allow them to react with the skin and promote drug penetration. In addition, polysaccharide-based nanotechnology enhances drug utilization efficiency. Various diseases are currently treated by polysaccharide-based transdermal drug delivery devices and exhibit promising futures. The most current knowledge on these excellent materials will be thoroughly discussed by reviewing polysaccharide-based transdermal drug delivery strategies.

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“…X. Yu et al (2022) designed a dissolving MN patch that could release triple antibiotic, enzymolysis, and photothermal agents to inhibit biofilm formation by Staphylococcus aureus and Pseudomonas aeruginosa during wound healing. Other researchers have employed biodegradable MN patches with a multidrug delivery capability for cancer treatments (Z. Wang et al, 2022; Zhao et al, 2021). For example, Z. Wang et al (2022) developed a biodegradable silk fibroin MN patch that could circumvent the blood–brain barrier and release the targeted drug and chemotherapeutic agents directly to the tumor cells.…”

Section: Mns For Multidrug Deliverymentioning

confidence: 99%

“…Other researchers have employed biodegradable MN patches with a multidrug delivery capability for cancer treatments (Z. Wang et al, 2022;Zhao et al, 2021). For example, Z.…”

Section: Mns For Multidrug Deliverymentioning

confidence: 99%

Advances and challenges in developing smart, multifunctional microneedles for biomedical applications

Tavafoghi

Nasrollahi

Karamikamkar

et al. 2022

Biotech & Bioengineering

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Microneedles (MNs) have been developed as minimally invasive tools for diagnostic and therapeutic applications. However, in recent years, there has been an increasing interest in developing smart multifunctional MN devices to provide automated and closed-loop systems for body fluid extraction, biosensing, and drug delivery in a stimuli-responsive manner. Although this technology is still in its infancy and far from being translated into the clinic, preclinical trials have shown some promise for the broad applications of multifunctional MN devices. The main challenge facing the fabrication of smart MN patches is the integration of multiple modules, such as drug carriers, highly sensitive biosensors, and data analyzers in one miniaturized MN device. Researchers have shown the feasibility of creating smart MNs by integrating stimuli-responsive biomaterials and advanced microscale technologies, such as microsensors and microfluidic systems, to precisely control the transportation of biofluids and drugs throughout the system. These multifunctional MN devices can be envisioned in two distinct strategies. The first type includes individual drug delivery and biosensing MN units with a microfluidic system and a digital analyzer responsible for fluid transportation and communication between these two modules.The second type relies on smart biomaterials that can function as drug deliverers and biosensors by releasing drugs in a stimuli-responsive manner. These smart biomaterials can undergo structural changes when exposed to external stimuli, such as pH and ionic changes, mimicking the biological systems. Studies have demonstrated a high potential of hydrogel-based MN devices for a wide variety of biomedical applications, such as drug and cell delivery, as well as interstitial fluid extraction. Biodegradable hydrogels have also been advantageous for fabricating multifunctional MNs due to their high loading capacity and biocompatibility with the drug of choice. Here, we first review a set of MN devices that can be employed either for biosensing or delivery of multiple target molecules and compare them to the conventional and more simple systems, which are mainly designed for singlemolecule sensing or delivery. Subsequently, we expand our insight into advanced MN systems with multiple competencies, such as body fluid extraction, biosensing,

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Intelligent and spatiotemporal drug release based on multifunctional nanoparticle-integrated dissolving microneedle system for synergetic chemo-photothermal therapy to eradicate melanoma

Cited by 58 publications

References 50 publications

GelMA/PEGDA microneedles patch loaded with HUVECs-derived exosomes and Tazarotene promote diabetic wound healing

GelMA/PEGDA microneedles patch loaded with HUVECs-derived exosomes and Tazarotene promote diabetic wound healing

Polysaccharide-Based Transdermal Drug Delivery

Advances and challenges in developing smart, multifunctional microneedles for biomedical applications

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