Intelligent microneedle patch with prolonged local release of hydrogen and magnesium ions for diabetic wound healing

In situ electrospun aloe-nanofiber membrane for chronic wound healing

“…Diabetes mellitus is a metabolic disease that seriously jeopardizes human health and is the fourth leading cause of death after cardiovascular diseases, tumors, and AIDS [ 1 ]. Impaired wound healing is a typical complication of diabetes [ 2 ]. Chronic lesions that occur on feet can deteriorate to form ulcers that lead to high rates of amputation and morbidity [ 3 , 4 ].…”

Biodegradable Implants for Internal Fixation of Fractures and Accelerated Bone Regeneration

“…Metallic alloys can be gradually corroded in vivo , but the biodegradability of them depends on the ratio of different ingredients which has been the focus of recent studies about alloys. Mg is biocompatible with rather low cytotoxicity which can release Mg 2+ and hydrogen for therapeutic effects, including enhancing angiogenesis and regulating an inflammatory reaction. , In particular, the in vivo biodegradability of Mg alloys avoids surgical intervention for removing implants. − Unfortunately, the excessive corrosion rate of pure Mg alloys would contribute to hydrogen accumulation and decreased mechanical integrity which restricts their physiological application. , The addition of coating, other alloy elements, and rare-earth elements have been testified as practical solutions for realizing controlled corrosion rate and enhanced mechanical strength of Mg alloys. Hou et al fabricated a MgZnCa alloy, within which 0.7 wt % zinc (Zn) was used for enhanced mechanical strength and 0.6 wt % calcium (Ca) was incorporated for increased castability (Figure a).…”

Multifunctional calcium polyphenol networks reverse the hostile microenvironment of trauma for preventing postoperative peritoneal adhesions

“…For SEM analysis, 5 × 10 4 Raw264.7 cells were inoculated into one well of a 24-well plate containing a sterilized silicon wafer. 57 After co-culture with 100 ng mL −1 LPS, LPS + 100 μg mL −1 CaPNs, or normal cell medium for 24 h, Raw264.7 cell silicon was removed from the plate and fixed with 2.5% glutaraldehyde for 30 min. Dehydration was conducted using various alcohol gradients (30%, 5 min; 50%, 5 min; 70%, 10 min; 80%, 10 min; 95%, 15 min; and 100%, 15 min).…”