Intense Pulsed Light and Laser Treatment of Facial Telangiectasias and Dyspigmentation

Ross, E. Victor; Smirnov, M. Z.; Pankratov, Michael; Altshuler, Gregory B.

doi:10.1111/j.1524-4725.2005.31925

Cited by 77 publications

(66 citation statements)

References 44 publications

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“…Nonablative skin rejuvenation involves the use of a cooling device to protect the epidermis, which allows a high energy laser/IPL source (with wavelengths that range from 570 to 1,340 nm) to be delivered to the dermis [1][2][3][4][5][6][7]. Histological evidence has suggested that non-ablative skin rejuvenation is associated with increased collagen production and collagen shrinkage [8,9].…”

Section: Discussionmentioning

confidence: 99%

“…Non-ablative skin rejuvenation involves the use of a laser/light source together with a cooling device, and in doing so improves the features of photoaging including lentigines, telangiectasia, pore size, skin texture, wrinkles, and skin laxity with minimal down time [1][2][3][4][5][6][7]. The use of a cooling device protects the epidermis, and in doing so allows a high-energy laser/intense pulse light (IPL) source (with a wavelength ranging from 570 to 1,340 nm) to be delivered to the dermis.…”

Section: Introductionmentioning

confidence: 99%

“…The use of a cooling device protects the epidermis, and in doing so allows a high-energy laser/intense pulse light (IPL) source (with a wavelength ranging from 570 to 1,340 nm) to be delivered to the dermis. A wide range of lasers or light sources can be used for non-ablative skin rejuvenation, including visible green-yellow (532 nm Nd:YAG, 585 nm or 595 nm pulsed dye laser), near infra-red and infra-red lasers (1,064 nm Nd:YAG, 1,320 nm Nd:YAG, 1,450 nm diode, 1,540 nm Erbium glass), and IPL sources [1][2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…Injury to the papillary dermal vessels not only allows effective treatment of facial telangiectasia, but also leads to the subsequent healing process and new collagen formation [1,2]. Near infra-red and infra-red lasers/light sources together with skin cooling target the water content in the dermis, and their photothermal effect, produced as a result of the laser-tissue interaction, causes a rise in the dermal temperature [3][4][5][6][7]. The consequences are collagen tightening, increased fibroblastic activity, and increased collagen production.…”

Section: Introductionmentioning

confidence: 99%

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An animal study of the effects on p16 and PCNA expression of repeated treatment with high‐energy laser and intense pulsed light exposure

et al. 2006

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Background and Objective: Non-ablative skin rejuvenation treatments that involve the use of laser/light sources together with cooling devices have gained much popularity in recent years due to the lack of down time that is associated with them. One important but neglected issue is long-term safety. Does the repeated use of non-ablative skin rejuvenation lead to photoaging? Are we creating another sun-bed phenomenon? Recently, we performed an in vitro study to examine the effect of sub-lethal QS 755 nm lasers on the expression of p16INK4a on melanoma cell lines, and found that sub-lethal laser damage could increase DNA damage, which led to an increase in p16 expression. Our objective was to assess the cutaneous effect of repeated exposure to high-energy lasers and intense pulsed light sources on male Institute of Cancer Research (ICR) mice. Study Design/Materials and Methods: Twenty-eight male ICR mice were divided into four groups. Other than the control group, all groups received either laser (585 nm pulsed dye laser or 1,320 nm Nd:YAG laser) or intense pulsed light (IPL) treatment. All four groups were anesthetized with a mixture of Hypnorm/Dormicum before treatment. The animals were irradiated twice a week for 6 months. Signs of toxicity such as mortality and weight loss were checked once a week. Skin tumor formation was evidenced by lesions of greater than 1 mm in diameter that persisted for 2 weeks. At the end of the 6 months, the expression of proliferating cell nuclear antigen (PCNA) and p16 in the mouse skin was determined by immunohistochemical staining and immunoblotting using specific monoclonal antibodies for mouse PCNA and p16. The results were expressed as mean AE standard error of the mean (SEM). Statistical difference was assessed by multiple ANOVA. A P-value of <0.05 was considered to be significant. Results: At the end of the 6 months, none of the animals had developed any signs of toxicity such as mortality or weight lost. There was no evidence of tumor formation. There were significant elevations of p16 and PCNA in all treated groups as compared to the control group (ANOVA P<0.05). This particularly applied to the group that was treated with the 1,320 nm Nd:YAG laser. Conclusion:The repeated use of high-energy laser and intense pulsed light source did not cause any toxicity in mice. The changes in p16 and PCNA imply that further studies are necessary to consider the implications of repeated exposure to longer wavelength radiation in human skin.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An animal study of the effects on p16 and PCNA expression of repeated treatment with high‐energy laser and intense pulsed light exposure

et al. 2006

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“…Many therapeutic modalities, especially laser systems [16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36] or intense pulsed light (IPL) [18,19,20] have been applied in the treatment of these telangiectasias. The aim of this study was to present a single-institution experience of treating extranasal telangiectasias by means of Nd:YAG laser.…”

Section: Introductionmentioning

confidence: 99%

Nd:YAG Laser Treatment for Extranasal Telangiectasias: A Retrospective Analysis of 38 Patients with Hereditary Hemorrhagic Telangiectasia and Review of the Literature

Papaspyrou

Schick²,

Kadah³

2016

ORL

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Background/Aims: Extranasal telangiectasiasare common amongsthereditary hemorrhagic telangiectasia (HHT) patients. Telangiectasias can be found at sites like the external nose, lips, oral cavity and fingers. Although not life threatening, they can be annoying for patients and lead to bleeding in some cases, necessitating treatment. Methods: The data of 38 HHT patients treated for extranasal telangiectasias during a period of 10 years by means of Nd:YAG laser were retrospectively analyzed. Results: The telangiectasias treated affected predominantly the tongue, facial skin and lips. During a minimum follow-up of 3 years, only 7 patients required a revision of surgery. Conclusion: This study shows that Nd:YAG laser constitutes a fast, safe and efficient therapeutic modality for the treatment of extranasal telangiectasias.

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Minimally Invasive Treatments and Procedures for Ageing Skin

Lowe

2010

Rook's Textbook of Dermatology

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Intense Pulsed Light and Laser Treatment of Facial Telangiectasias and Dyspigmentation

Abstract: BACKGROUND AND OBJECTIVE. A comparative overview is presented, both theoretical and clinical, for intense pulsed light (IPL) and laser treatment of facial telangiectasias and pigmented lesions.

Cited by 77 publications

References 44 publications

An animal study of the effects on p16 and PCNA expression of repeated treatment with high‐energy laser and intense pulsed light exposure

An animal study of the effects on p16 and PCNA expression of repeated treatment with high‐energy laser and intense pulsed light exposure

Nd:YAG Laser Treatment for Extranasal Telangiectasias: A Retrospective Analysis of 38 Patients with Hereditary Hemorrhagic Telangiectasia and Review of the Literature

Minimally Invasive Treatments and Procedures for Ageing Skin

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