Intense pulsed light therapy for acne-induced post-inflammatory erythema

Mathew, Minu L; Karthik, Rajiv; Mallikarjun, M; Bhute, Soumya; Varghese, Aiswarya Liz

doi:10.4103/idoj.idoj_306_17

Cited by 24 publications

(31 citation statements)

References 23 publications

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“…Clinical improvement and consistent histological changes were attributed to controlled inflammation and modulated neovasculogenesis. Consistent with a previous report [ 20 ], we found decreased EAS and red areas recorded by the VISIA-CR system. IPL-induced vascular destruction is mainly caused by selective photothermolysis.…”

Section: Discussionsupporting

confidence: 93%

Intense Pulsed Light Therapy Improves Acne-Induced Post-inflammatory Erythema and Hyperpigmentation: A Retrospective Study in Chinese Patients

Wang

et al. 2022

Dermatol Ther (Heidelb)

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Introduction Post-inflammatory erythema (PIE) and post-inflammatory hyperpigmentation (PIH) are the most common acne-related sequelae with no effective treatments. By combining different cut-off filters, intense pulsed light (IPL) therapy can effectively treat these conditions with few side effects. While the safety and effectiveness of IPL for treating post-burn hyperpigmentation is well known, there is little evidence for its benefits for acne-related PIH. In this article, we evaluate the efficacy and safety of IPL for the treatment of acne-related PIE and PIH. Methods This retrospective study evaluated 60 patients with more than 6 months of PIE and PIH treated by the same IPL device and similar protocols. The treatment included three to seven sessions at 4–6-week intervals, and three cut-off filters (640 nm, 590 nm and 560 nm) were used sequentially in each session. Using the Global Aesthetic Improvement Scale (GAIS), Cardiff Acne Disability Index (CADI), and Erythema Assessment Scale (EAS), patients were evaluated on the basis of their facial photographs. The facial brown spots and red areas were visualised and analysed using the VISIA-CR system. Six months after the last treatment, the patients were assessed for acne relapse or any side effects.Please check and confirm that the authors and their respective affiliations have been correctly processed and amend if necessary.Checked and confirmed. No further corrections. Results On the basis of the GAIS, 49 of 60 patients (81.7%) showed complete or partial clearance of erythema and hyperpigmentation. The CADI and EAS scores showed significant improvement ( p < 0.01) after IPL treatment compared with pre-treatment. A significant reduction ( p < 0.01) in the facial brown spots and red areas was seen after IPL treatment. While no long-term side effects were reported, seven patients (11.7%) experienced acne relapse at follow-up. Conclusion IPL is an effective and safe treatment for acne-related PIE and PIH.

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Section: Discussionsupporting

confidence: 93%

Intense Pulsed Light Therapy Improves Acne-Induced Post-inflammatory Erythema and Hyperpigmentation: A Retrospective Study in Chinese Patients

Wang

et al. 2022

Dermatol Ther (Heidelb)

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“…In addition, this modality was used to treat both acne and erythema in patients with persistent acne erythema with having additional benefits such as reducing oil production, improving skin tone, and improving texture. Moreover, all adverse effects including erythema, hyperpigmentation, and hypopigmentation were transient 9 …”

Section: Resultsmentioning

confidence: 97%

“…Some of these topical treatments include topical tranexamic acid, 4 oxymetazoline (OXZ), 2 vitamin C gel, 5 and brimonidine tartrate solution 6 . Furthermore, a variety of light and laser therapies including pulsed‐dye lasers, 3 Q‐Switched Neodymium:yttrium aluminum‐garnet (Nd:YAG) laser, 7 erbium glass fractional laser, 8 and intense pulsed light (IPL) devices have been studied for treating PAE 9 . Another modality that has shown efficacy in PAE patients is radiofrequency 10 …”

Section: Introductionmentioning

confidence: 99%

Post‐acne erythema treatment: A systematic review of the literature

Kalantari

Dadkhahfar

Etesami

2022

J of Cosmetic Dermatology

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Post-acne erythema (PAE) is a common sequela of acne inflammation, and it refers to telangiectasia and erythematous lesions remaining after the acne treatment. Although some PAE lesions may improve over time, persisting PAE might be esthetically undesirable for patients. The efficacy of various treatment options for PAE has been investigated in many studies but there exists no gold standard treatment modality. In this study, we aimed to give a systematic literature review on various treatment options for PAE, the advantage of each modality, and compare their efficacy, safety, and feasibility. By using the selected keywords, we carried out a systematic search for articles published from the inception to 28 April 2021 in PubMed/Medline and Embase databases. Of the 5796 initially retrieved articles, 18 of them were fully eligible to be enrolled in our study. In this study, we found that light and laser-based devices were the most frequently used treatments for PAE. Generally, pulsed-dye lasers were the most commonly used laser devices for PAE. Neodymium:yttrium aluminum-garnet lasers were the second most commonly used modalities in treating PAE. Topical treatments such as oxymetazoline, tranexamic acid, and brimonidine tartrate are promising treatments in reducing PAE lesions. In our study, no severe side effects were found. In conclusion, both laser devices and topical agents seem to be effective for PAE lesions; however, further randomized clinical trials are needed in this field.

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“…3 other lasers like 589/1319 laser system have proven good results in treatment of acne and post acne. 11 Short-pulsed 1064 nm laser has been tried for atrophic post acne scar (PAS) and proved to be beneficial in PAE improvement and has the advantage of being relatively pain free. 12 They all showed significant results in improving PAE, they have the disadvantage of being relatively high cost, can cause pigmentary changes, some are painful, 13 and downtime needed after sessions before patients return to their daily life routine and they are not easily available at all outpatient clinics, unlike topical treatment such as oxymetazoline (OXZ), 14 brimonidine, 5 and TXA 6,15 which can be easily prepared and easily applied by patients at home.…”

Section: Introductionmentioning

confidence: 99%

“…Also, other procedures such as intense pulsed light therapy 10 and fractional radiofrequency micro needling 3 . other lasers like 589/1319 laser system have proven good results in treatment of acne and post acne 11 . Short‐pulsed 1064 nm laser has been tried for atrophic post acne scar (PAS) and proved to be beneficial in PAE improvement and has the advantage of being relatively pain free 12 …”

Section: Introductionmentioning

confidence: 99%

A split face comparative study using a novel triple combination therapy for the treatment of persistent post acne erythema

Agamia

El‐Nagdy

Elariny

2022

Dermatologic Therapy

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Persistent post acne erythema (PAE) is common cosmetically unacceptable and challenging sequelae of acne lesions. Tranexamic acid (TXA) is an antifibrinolytic agent that shows a positive effect on wound healing in several studies, and it showed benefits in treating skin diseases like melasma, rosacea erythema and ultraviolet induced pigmentations. Oxymetazoline (OXZ) is a synthetic, highly selective agonist for alpha 1A‐adrenoceptor. It is a potent vasoconstrictor. OXZ hydrochloride 1% cream was approved by the FDA in January 2017 as a topical treatment for persistent facial erythema in rosacea patients. Brimonidine tartrate (BMT) is highly selective α2 adrenergic receptor agonist, results in direct, potent vasoconstriction of small arterioles and veins. In 2013, brimonidine 0.33% gel was the first topical therapy to be FDA approved for the treatment of persistent facial erythema from rosacea. To evaluate the efficacy and safety of topical triple combination (TXA 5% + OXZ 1.5% + BMT 0.33%) in the treatment of PAE planned as split face comparative study. This study was conducted on 40 patients diagnosed with persistent PAE for at least 3 months, the right side of the face was treated with topical triple combination in liposomal base and was compared to the left side to which topical lipocream (placebo) was applied as a control. Our treatment plan lasted for 3 months. According to the investigator's global assessment of photographs and computerized analysis of erythema using image analysis software, topical triple combination applied on the right side of face was significantly effective in diminishing PAE when compared to topical placebo left side. Topical triple combination is a safe and cost‐effective treatment for PAE.

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Intense pulsed light therapy for acne-induced post-inflammatory erythema

Cited by 24 publications

References 23 publications

Intense Pulsed Light Therapy Improves Acne-Induced Post-inflammatory Erythema and Hyperpigmentation: A Retrospective Study in Chinese Patients

Intense Pulsed Light Therapy Improves Acne-Induced Post-inflammatory Erythema and Hyperpigmentation: A Retrospective Study in Chinese Patients

Post‐acne erythema treatment: A systematic review of the literature

A split face comparative study using a novel triple combination therapy for the treatment of persistent post acne erythema

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