Intensive regional vaccination with a gI-deleted vaccine markedly reduces pseudorabies virus infections

Stegeman, J.A.; Tielen, M.J.M.; Kimman, Tjeerd G.; VanOirschot, J. T.; Hunneman, W. A.; Berndsen, F. W.

doi:10.1016/0264-410x(94)90312-3

Cited by 33 publications

(14 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In general, ADV modified live virus (MLV) vaccines are very effective at inducing protective immunity under experimental conditions (reviewed in [19,32,58]). Similarly, under field conditions, intensive regional vaccination programs have been very effective at controlling the spread of the disease between herds and reducing the incidence of infection [42][43][44]. The effectiveness of a ADV vaccine is dependent on the immunization program, strain of the vaccine virus, level of exposure to the virus and the level of maternally derived antibodies at the time of vaccination [4,11,14,50,52,55].…”

Section: Immunity To Inactivated and Modified Live Aujeszky's Diseasementioning

confidence: 99%

Aujeszky's disease virus: opportunities and challenges

Zuckermann¹

2000

Vet. Res.

View full text Add to dashboard Cite

-Since its description in 1902, Aujeszky's disease (AD) has become one of the most thoroughly examined viral diseases of swine. The causative agent, Aujeszky's disease virus (ADV), is a neurotropic alphaherpesvirus that produces fatal encephalitis in newborn pigs and a milder syndrome in older animals. In several instances this virus has been used as a test case to examine novel vaccine concepts in swine, including the honor of being the first genetically modified vaccine used in the field. Furthermore, the examination of the immune response to infection or vaccination with this virus has revealed important information about the function of the porcine immune system, including evidence on the existence of a dichotomy between the humoral and cellular immune response in swine. This review presents a summary of research where ADV has been a valuable tool for the development of novel vaccines and has provided information to better understand the immune response of swine to infectious agents. Aujeszky's disease virus / immunity / vaccine / T cells / pigRésumé -Virus de la maladie d'Aujeszky : perspectives et défis. Depuis sa description en 1902, la maladie d'Aujeszky est devenue l'une des maladies virales du porc les plus minutieusement étu-diées. L'agent pathogène responsable de la maladie, le virus de la maladie d'Aujeszky, est un alphaherpesvirus neurotrope qui provoque des encéphalites fatales chez le porc nouveau-né, et un syndrome plus modéré chez les animaux plus âgés. À plusieurs reprises, ce virus a été utilisé expérimentalement pour l'étude de nouveaux concepts vaccinaux chez le porc, et a eu l'honneur d'être le premier vaccin génétiquement modifié utilisé sur le terrain. De plus, l'examen de la réponse immunitaire à l'infection ou à la vaccination par ce virus a révélé des informations importantes concernant le fonctionnement du système immunitaire porcin. En particulier, des preuves de l'existence d'une dichotomie entre les réponses immunitaires humorale et cellulaire chez le porc ont été mises en évidence. Cet article de synthèse résume la recherche pour laquelle ADV a été un outil précieux pour le déve-loppement de nouveaux vaccins, et a apporté des informations pour une meilleure compréhension de la réponse immunitaire du porc aux agents infectieux. Vet. Res. 31 (2000) 121-131 121 virus de la maladie d'Aujeszky / immunité / vaccin / cellules T / porc

show abstract

Section: Immunity To Inactivated and Modified Live Aujeszky's Diseasementioning

confidence: 99%

Aujeszky's disease virus: opportunities and challenges

Zuckermann¹

2000

Vet. Res.

View full text Add to dashboard Cite

show abstract

“…Stegeman et al (22,24) showed a clear effect of area-wide vaccination on the transmission of the virus in a PRV endemic region, but will such a programme be successful if R is greater than 1 among finishing pigs? In farrow-to-finish herds, breeding pigs and finishing pigs are usually housed separately.…”

Section: Implications Of the Possibility Of Major Outbreaks Among Vacmentioning

confidence: 99%

Dynamics of pseudorabies virus infections in vaccinated pig populations: A review

Stegeman¹,

Jong²,

Nes

et al. 1997

Veterinary Quarterly

View full text Add to dashboard Cite

“…Using virus proteinspecific antibody assays, vaccinated animals can be distinguished from field virus-infected animals. As reference vaccine, strain 783 0/W was chosen on the basis of its good performance during the large field study preceding the start of the eradication campaign (21).…”

Section: Compulsory Vaccinationmentioning

confidence: 99%

Aujeszky's disease virus eradication campaign successfully heading for last stage in the Netherlands

Elbers

Braamskamp

Dekkers

et al. 2000

Veterinary Quarterly

View full text Add to dashboard Cite

SUMMARYThe Aujeszky's disease virus (ADV) eradication campaign in the Netherlands is based on compulsory vaccination and certification of ADV-free herds and consists of three stages: reduction of transmission of ADV, tracing and elimination of remaining sources of ADV, and, in the last stage prohibition of vaccination. This paper summarizes the progress made in the first two stages of the eradication.Between 1994-1999, ADV seroprevalence decreased sharply in all four regions in the Netherlands, both in the sow and the finishing pig population. In the sow population, the mean ADV prevalence in the northern, eastern and western regions decreased to less than 0.5% in the first quarter of 1998, and to approximately 1% in the southern region. For the finishing pig population, the mean ADV prevalence decreased to less than 0.6% in all fourregions in the first quarter of 1998. The proportion of sow herds that were certified ADV-free increased steadily from approximately 40% in the last quarter of 1996 to 96% in the first quarter of 1999. The proportion of finishing pig herds that were certified ADV-free showed the same spectacular increase as in the sow population: from approximately 14% in the last quarter of 1996 to 90% in the first quarter of 1999. It is anticipated that the last stage of the ADV eradication campaign, stopping vaccination, will be achieved very soon.Monitoring wild boars for ADV between 1994 and 1999 indicated that ADV is uncommon within the wild boar population. Therefore, it seems that ADV infection in the wild boar population is not an important reservoir in the Netherlands.

show abstract

Intensive regional vaccination with a gI-deleted vaccine markedly reduces pseudorabies virus infections

Cited by 33 publications

References 20 publications

Aujeszky's disease virus: opportunities and challenges

Aujeszky's disease virus: opportunities and challenges

Dynamics of pseudorabies virus infections in vaccinated pig populations: A review

Aujeszky's disease virus eradication campaign successfully heading for last stage in the Netherlands

Contact Info

Product

Resources

About