Oral squamous cell carcinoma (OSCC) is the most occurring cancer of the oral cavity showing changes based on-site, sex, age and habits of the population. The purpose of the study is to correlate the occurrence of oral squamous cell carcinoma at specific anatomical sites with age and gender. The present study is a retrospective study, including data from June 2019 to April 2020. Data of 50 OSCC patients including age, gender, site of the lesion, the onset of symptoms, treatment done, were collected, tabulated and then statistically analyzed. Results revealed that buccal mucosa was the most common site of occurrence in males (61.50%): Correlation of gender with the location of oscc was statistically not significant with a p-value higher than 0.05. Regarding the association of age with a site of oscc occurrence, buccal mucosa was the common site of involvement in individuals below 50 years of age (54.50%), followed by tongue 23.50% and 21% in above 50 years of age. Correlation of age with the site of oscc occurrence was statistically insignificant (p>0.05). Within the limits of the study, it can be concluded that the site of occurrence of OSCC is more governed by habits involved than age and gender itself. But an investigation involving a larger population would give a more comprehensive outcome.