Interaction among human leucocyte antigen–peptide–T cell receptor complexes in cow's milk allergy: the significance of human leucocyte antigen and T cell receptor–complementarity determining region 3 loops

Sakaguchi, Hideki; Inoue, Ryosuke; Kaneko, Hideo; Watanabe, Mahito; Suzuki, Kiyotaka; Kato, Zenichiro; Matsushita, Sho; Kondo, Naomi

doi:10.1046/j.1365-2222.2002.01370.x

Cited by 31 publications

(21 citation statements)

References 39 publications

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“…It has also been suggested that HLA-DRB1*04 would be associated with sensitivity to ␤-lactoglobulin, a lipocalin allergen of cow's milk (Sakaguchi et al 2002). However, in contrast to our present results with Bos d 2, our previous data with the major dog allergen Can f 1 suggested that the HLA haplotype DRB1*04-DQB1*0302 would protect from allergy instead of predisposing to it (Kinnunen et al 2005).…”

Section: Discussioncontrasting

confidence: 99%

Association of HLA class II alleles with sensitization to cow dander Bos d 2, an important occupational allergen

et al. 2012

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Section: Discussioncontrasting

confidence: 99%

Association of HLA class II alleles with sensitization to cow dander Bos d 2, an important occupational allergen

et al. 2012

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“…As a consequence, we were not able to further characterize the phenotype of peripheral blood cells reacting to b-LG. We found that proliferative responses were strongly reduced when blocking HLA-DQ and -DR molecules, in agreement with previous studies showing that allergens predominantly activate major histocompatibility complex-class II restricted CD4ϩ T cells (3,23,24). Furthermore, our findings are in line with previous reports demonstrating the presence of food-specific T lymphocytes also in nonallergic, healthy subjects (13,17,18,23,25).…”

Section: Discussionsupporting

confidence: 93%

Peripheral Blood Immune Response Elicited by Beta-Lactoglobulin in Childhood Cow's Milk Allergy

et al. 2011

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Several studies analyzing the immune responses in patients with cow's milk allergy (CMA) have used T-cell lines or T-cell clones that require prolonged in vitro cell culturing and may result in a switched cell phenotype and function. We investigated immune responses to beta-lactoglobulin (b-LG) in peripheral blood mononuclear cells after a short in vitro antigen stimulation in children with acute CMA (both IgE-mediated and non-IgE-mediated forms) and in those who outgrew an IgE-mediated CMA. Healthy controls were also investigated. Peripheral blood mononuclear cells were assayed for IL-13, IFN-␥, IL-4, and IL-10. Although b-LG induced a cytokine production and/or cell proliferation almost in all children, included healthy controls, differences were observed among the four groups. Children with IgE-mediated CMA had a marked Th2-response, with high IL-13 production and proliferation, but low IFN-␥; by contrast, children with non-IgE-mediated CMA produced no, or very low, IL-13 and cell proliferation. Children, who outgrew CMA, showed a shift to a Th1-response, with reduced IL-13 and increased IFN-␥. IL-10-responses were high in all groups, with the highest level in healthy children; by contrast, IL-4 was undetectable in all children. This study highlights the use of shortly stimulated peripheral blood cells to investigate the food-induced immune responses. (Pediatr Res 70: 549-554, 2011)

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“…Despite this, human T cell epitopes of lipocalin allergens are largely unknown. Information on their location is only available for Bos d 2, the major bovine respiratory allergen (13), Rat n 1, the major rat urinary allergen (23), and ␤-lactoglobulin, a milk allergen (24,29,30). In the present study, we have mapped the antigenic determinants of the major dog allergen, Can f 1, because knowing these determinants is a prerequisite for the development of peptide-based modes of allergen immunotherapy.…”

Section: Discussionmentioning

confidence: 99%

T Cell Epitope-Containing Peptides of the Major Dog Allergen Can f 1 as Candidates for Allergen Immunotherapy

Immonen

Farci

Taivainen

et al. 2005

The Journal of Immunology

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One prerequisite for developing peptide-based allergen immunotherapy is knowing the T cell epitopes of an allergen. In this study, human T cell reactivity against the major dog allergen Can f 1 was investigated to determine peptides suitable for immunotherapy. Seven T cell epitope regions (A–G) were found in Can f 1 with specific T cell lines and clones. The localization of the epitope regions shows similarities with those of the epitopes found in Bos d 2 and Rat n 1. On average, individuals recognized three epitopes in Can f 1. Our results suggest that seven 16-mer peptides (p15–30, p33–48, p49–64, p73–88, p107–122, p123–138, and p141–156), each from one of the epitope regions, show widespread T cell reactivity in the population studied, and they bind efficiently to seven HLA-DRB1 molecules (DRB1*0101, DRB1*0301, DRB1*0401, DRB1*0701, DRB1*1101, DRB1*1301, and DRB1*1501) predominant in Caucasian populations. Therefore, these peptides are potential candidates for immunotherapy of dog allergy.

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Interaction among human leucocyte antigen–peptide–T cell receptor complexes in cow's milk allergy: the significance of human leucocyte antigen and T cell receptor–complementarity determining region 3 loops

Abstract: We proposed the motif of the interaction between the HLA-DRB10405 allele and antigen peptide, and suggested that HLA-DRB10405 is an immunoregulatory gene product for T cell responses to BLG.

Cited by 31 publications

References 39 publications

Association of HLA class II alleles with sensitization to cow dander Bos d 2, an important occupational allergen

Association of HLA class II alleles with sensitization to cow dander Bos d 2, an important occupational allergen

Peripheral Blood Immune Response Elicited by Beta-Lactoglobulin in Childhood Cow's Milk Allergy

T Cell Epitope-Containing Peptides of the Major Dog Allergen Can f 1 as Candidates for Allergen Immunotherapy

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Interaction among human leucocyte antigen–peptide–T cell receptor complexes in cow's milk allergy: the significance of human leucocyte antigen and T cell receptor–complementarity determining region 3 loops

Abstract: We proposed the motif of the interaction between the HLA-DRB1*0405 allele and antigen peptide, and suggested that HLA-DRB1*0405 is an immunoregulatory gene product for T cell responses to BLG.

Cited by 31 publications

References 39 publications

Association of HLA class II alleles with sensitization to cow dander Bos d 2, an important occupational allergen

Association of HLA class II alleles with sensitization to cow dander Bos d 2, an important occupational allergen

Peripheral Blood Immune Response Elicited by Beta-Lactoglobulin in Childhood Cow's Milk Allergy

T Cell Epitope-Containing Peptides of the Major Dog Allergen Can f 1 as Candidates for Allergen Immunotherapy

Contact Info

Product

Resources

About

Abstract: We proposed the motif of the interaction between the HLA-DRB10405 allele and antigen peptide, and suggested that HLA-DRB10405 is an immunoregulatory gene product for T cell responses to BLG.