Interaction among Hydrogen Sulfide and Other Gasotransmitters in Mammalian Physiology and Pathophysiology

Huang, Yaqian; Jin, Hongfang; Zhang, Heng; Tang, Chaoshu; Du, Junbao

doi:10.1007/978-981-16-0991-6_9

Cited by 18 publications

(10 citation statements)

References 227 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The gaseous neurotransmitters carbon monoxide (CO) and hydrogen sulfide (H 2 S) exert multiple biological functions, and there are several similarities between both gases, including: (1) a similar pattern of distribution within the central (CNS) and peripheral nervous systems (PNS); (2) the ability to diffuse freely across intra- and intercellular compartments; (3) both mediate similar physiological functions such as the regulation of cardiovascular, neuronal, respiratory, digestive, and immune systems [ 1 ]. In addition, the crosstalk between CO and H 2 S has been described, especially in the gastrointestinal digestive system [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

The Interaction between Carbon Monoxide and Hydrogen Sulfide during Chronic Joint Pain in Young Female Mice

2022

View full text Add to dashboard Cite

A relationship between carbon monoxide (CO) and hydrogen sulfide (H2S) has been described in different pathological conditions, but their interaction in modulating joint pain has not yet been investigated. In young female mice with monosodium acetate-induced joint degeneration and pain, we assessed: (1) the effects of CORM-2 (tricarbonyldichlororuthenium(II)dimer), a CO-releasing molecule, and CoPP (cobalt protoporphyrin IX), an inducer of heme oxygenase 1 (HO-1), administered alone and combined with low doses of two slow-releasing H2S donors, DADS (diallyl disulfide) and GYY4137 (morpholin-4-ium 4-methoxyphenyl(morpholino) phosphinodithioate dichloromethane complex) on the mechanical allodynia and loss of grip strength provoked by joint degeneration; (2) the role of Nrf2, NAD(P)H: quinone oxidoreductase 1 (NQO1) and HO-1 in the antinociceptive actions of H2S donors; (3) the impact of DADS and GYY4137 treatment on the expression of Nrf2 and several antioxidant proteins in dorsal root ganglia (DRG) and periaqueductal gray matter (PAG). Our data showed that treatment with H2S donors inhibited allodynia and functional deficits, while CORM-2 and CoPP only prevented allodynia. The Nrf2 pathway is implicated in the analgesic actions of DADS and GYY4137 during joint degeneration. Moreover, the co-administration of low doses of CORM-2 or CoPP with DADS or GYY4137 produced higher antiallodynic effects and greater recovery of grip strength deficits than those produced by each of these compounds alone. The activation of the antioxidant system caused by H2S donors in DRG and/or PAG might explain the enhancement of antinociceptive effects. These data reveal a positive interaction between H2S and CO in modulating joint pain in female mice.

show abstract

Section: Introductionmentioning

confidence: 99%

The Interaction between Carbon Monoxide and Hydrogen Sulfide during Chronic Joint Pain in Young Female Mice

2022

View full text Add to dashboard Cite

show abstract

“…While it is known that H 2 S levels and its enzymes are dysregulated following HBI, it was only recently explored the hypothesis that they may influence immune cell functions in neonatal mice, including local microglia and infiltrating peripheral immune cells [125][126][127]. Increase of H 2 S levels was obtained using L-Cysteine, a common substrate for its production [14,128]. H 2 S treatment inhibited CD4+T cell infiltration while simultaneously dramatically lowering the fraction of Th1 cells and increasing the Th17/Th2 ratio following HBI.…”

Section: Role Of H 2 S In Th17 Cellsmentioning

confidence: 99%

“…It belongs to the "gasotransmitter" family, along with nitric oxide (NO), carbon monoxide (CO), and sulfur dioxide (SO 2 ). Once considered as poisonous and possibly fatal gases, they are now recognized as crucial intracellular signaling molecules with a wide range of physiological activities, and several H 2 S-releasing compounds are currently in preclinical and clinical trial, showing promising effects and therapeutic potential [14]. Specifically, the relevance of H 2 S in immune and inflammatory responses has long been a relevant topic of scientific research.…”

Section: Introductionmentioning

confidence: 99%

Buffering Adaptive Immunity by Hydrogen Sulfide

Pozzi

Gobbi

Masselli

et al. 2022

Cells

View full text Add to dashboard Cite

T cell-mediated adaptive immunity is designed to respond to non-self antigens and pathogens through the activation and proliferation of various T cell populations. T helper 1 (Th1), Th2, Th17 and Treg cells finely orchestrate cellular responses through a plethora of paracrine and autocrine stimuli that include cytokines, autacoids, and hormones. Hydrogen sulfide (H2S) is one of these mediators able to induce/inhibit immunological responses, playing a role in inflammatory and autoimmune diseases, neurological disorders, asthma, acute pancreatitis, and sepsis. Both endogenous and exogenous H2S modulate numerous important cell signaling pathways. In monocytes, polymorphonuclear, and T cells H2S impacts on activation, survival, proliferation, polarization, adhesion pathways, and modulates cytokine production and sensitivity to chemokines. Here, we offer a comprehensive review on the role of H2S as a natural buffer able to maintain over time a functional balance between Th1, Th2, Th17 and Treg immunological responses.

show abstract

“…For example, we will show how four small gaseous molecules previously considered as toxic gases, namely hydrogen sulfide (H2S), nitric oxide (NO), carbon monoxide (CO) and sulfur dioxide (SO2), have been recently assigned to the mammalian family og gasotransmitters (Huang et al, 2021). Gasotransmittes are signalling molecules that freely diffuse through the intestinal cellular membranes, playing crucial physiological and pathophysiological roles in many processes such as stomach acid release, smooth muscles relaxation, local blood flow adjusting, inflammation activation, angiogenesis, heart contractility control, etc (Verbeure et al, 2021).…”

Section: Physiology Of Individual Intestinal Gasesmentioning

confidence: 99%

Biological Relevance of Intestinal Gases in Healthy Humans

Tozzi¹,

Minella²

2022

Preprint

View full text Add to dashboard Cite

Intestinal gases are usually discarded as physiologically inert, useless sub-products of colonic fermentation that must be expelled to prevent discomfort and meteorism. Starting from the observation that many living beings use exogenous and/or endogenous gases to attain evolutionary benefits, we question whether intestinal gases in healthy humans could have underestimated physiological effects, either intestinal or extra-intestinal. We examine gaseous volume, composition, source and local distribution in proximal as well as distal gut, providing extensive data that may serve as reference for future studies. We analyze each one of the most abundant intestinal gases and describe their diffusive patterns, active trans-barrier transport dynamics, chemical properties, intra-/extra-intestinal metabolic effects mediated by intracellular, extracellular, paracrine and distant actions. Discussing the physical properties of the whole intestinal gaseous mixture, we illustrate how changes in volume/pressure can be generated by two different mechanisms, namely, physical muscular gut contraction and biological colonic fermentation, with quite different metabolic outcomes. The experimental gas laws suggest that the gaseous exchanges between lumen and bloodstream are impaired by muscular contraction and improved by muscular relaxation. In turn, the surface-area-to-volume ratio suggests that the gaseous exchanges are impaired by microorganismal overproduction and improved by microorganismal reduction. Further, theoretical stochastic approaches from probability theory indicate that the non-turbulent, random paths of gas molecules inside colonic haustra do not homogenously spread over the whole mucosal surface. This means that the intestinal area available for lumen/blood metabolic exchanges is much less than expected not just in disease states, but also in healthy individuals.

show abstract

Interaction among Hydrogen Sulfide and Other Gasotransmitters in Mammalian Physiology and Pathophysiology

Cited by 18 publications

References 227 publications

The Interaction between Carbon Monoxide and Hydrogen Sulfide during Chronic Joint Pain in Young Female Mice

The Interaction between Carbon Monoxide and Hydrogen Sulfide during Chronic Joint Pain in Young Female Mice

Buffering Adaptive Immunity by Hydrogen Sulfide

Biological Relevance of Intestinal Gases in Healthy Humans

Contact Info

Product

Resources

About