2020
DOI: 10.21203/rs.3.rs-40608/v1
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Interaction Analysis of Statistically Enriched Mutations Identified in Cameroon Recombinant Subtype CRF02_AG that can Influence the Development of Dolutegravir Drug Resistance Mutations

Abstract: Abstract Background The Integrase (IN) strand transfer inhibitor (INSTI), Dolutegravir (DTG), has been given the green light to form part of first-line combination antiretroviral therapy (cART) by the World Health Organization (WHO). DTG is clinically effective against all HIV-1 isolates previously showing resistance to INSTIs.Methods We evaluated the HIV-1 CRF02_AG IN gene sequences from Cameroon for the presence of resista… Show more

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