Interaction and Binding Modes of bis-Ruthenium(II) Complex to Synthetic DNAs

Barai, Hasi Rani; Lee, Dong Jin; Han, Sung Wook; Jang, Yoon Jung

doi:10.3390/met6060141

Cited by 6 publications

(4 citation statements)

References 35 publications

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“…Furthermore, it was still interesting that there was no activity evident for complex 3's major ligand 2BUT and even its analogue complex 6 from the previous work. In that case, we suspect that, upon coordinating 2BUT with ruthenium, the 2BUT ligand became enabled or complex 2 which had no 2BUT ligand became enabled when coordinated with the 2BUT ligand, consistent with previous studies [17][18][19][20]. As for the analogue complex 6, we suspected the introduction of the bridge in complex 3 may have induced the bioactivity of this complex towards MRSA.…”

Section: Disc Diffusion Assaysupporting

confidence: 85%

Antibacterial Activity of 2-Picolyl-polypyridyl-Based Ruthenium (II/III) Complexes on Non-Drug-Resistant and Drug-Resistant Bacteria

Matshwele

Odisitse

Mapolelo

et al. 2021

Bioinorganic Chemistry and Applications

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A new hexadentate 2-picolyl-polypyridyl-based ligand (4, 4'-(butane-1, 4-diylbis(oxy))bis(N, N-bis(pyridin-2-ylmethyl)aniline)) (2BUT) (1) and its corresponding Ru(II/III) complexes were synthesized and characterized, followed by assessment of their possible bioactive properties towards drug-resistant and non-drug-resistant bacteria. Spectroscopic characterization of the ligand was done using proton NMR, FTIR, and ESI-MS, which showed that the ligand was successfully synthesized. The Ru(II/III) complexes were characterized by FTIR, UV/Vis, elemental analysis, proton NMR, ESI-MS, and magnetic susceptibility studies. The analysis of ESI-MS data of the complexes showed that they were successfully synthesized. Empirical formulae derived from elemental analysis of the complexes also indicated successful synthesis and relative purity of the complexes. The important functional groups of the ligands could be observed after complexation using FTIR. Magnetic susceptibility data and electronic spectra indicated that both complexes adopt a low spin configuration. The disc diffusion assay was used to test the compounds for antibiotic activity on two bacteria species and their drug-resistant counterparts. The compounds displayed antibiotic activity towards the two non-drug-resistant bacteria. As for the drug-resistant organisms, only [Ru2(2BUT)(DMF)2(DPA)2](BH4)43 and 2, 2-dipyridylamine inhibited the growth of MRSA. Gel electrophoresis DNA cleavage studies showed that the ligands had no DNA cleaving properties while all the complexes denatured the bacterial DNA. Therefore, the complexes may have DNA nuclease activity towards the bacterial genomic material.

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Section: Disc Diffusion Assaysupporting

confidence: 85%

Antibacterial Activity of 2-Picolyl-polypyridyl-Based Ruthenium (II/III) Complexes on Non-Drug-Resistant and Drug-Resistant Bacteria

Matshwele

Odisitse

Mapolelo

et al. 2021

Bioinorganic Chemistry and Applications

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“…In this paper, we investigate the potential of rutheniumbased antibiotics against non-drug-resistant bacterial strains and drug-resistant strains. e biological application of ruthenium has increased over the years, especially after the realization of this metal's important bioactive properties which include anticancer, antimicrobial, and antiviral properties [3][4][5][6][7][8]. Ruthenium complexes also have some interesting chemical and physical properties which make them good candidates as potential drugs.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Mixed Ligand Ruthenium (II/III) Complexes and Their Antibacterial Evaluation on Drug-Resistant Bacterial Organisms

Matshwele

Nareetsile

Mapolelo

et al. 2020

Journal of Chemistry

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The potential antimicrobial properties of a tridentate polypyridyl ligand 4-butoxy-N,N-bis(pyridin-2-ylmethyl)aniline (BUT) 1 and its corresponding mixed ligand ruthenium complexes were investigated on drug-resistant and non-drug-resistant bacterial species. The ligand and its complexes were synthesized and successfully characterized by 1H NMR, UV/Vis, and FTIR spectra; ESI-MS; and magnetic susceptibility. Electronic spectra and magnetic susceptibility of these Ru(II)/(III) complexes suggest that they are of a low spin crystal field split, where the Ru(III) is a d5 and Ru(II) d6 low spin. These compounds were tested for antibacterial activity on two bacterial species: Staphylococcus aureus (S. aureus) and Klebsiella pneumoniae (K. pneumoniae), as well as their drug-resistant strains methicillin-resistant Staphylococcus aureus (MRSA) and multidrug resistant Klebsiella pneumoniae (MDR K. pneumoniae). All the compounds inhibited growth of the two non-drug-resistant bacteria and only one drug-resistant strain MRSA. However, only the ligands BUT and 2,2-dipyridylamine showed activity against MRSA, while all complexes did not show any antibacterial activity on MRSA. We observed large zones of inhibition for the Gram-positive S. aureus and MRSA bacteria, compared to the Gram-negative K. pneumoniae bacteria. DNA cleavage studies with gel electrophoresis showed denatured bacterial DNA on the gel from all the complexes, with the exception of the ligand, suggesting DNA nuclease activity of the complexes in the bacterial DNA.

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“…Ruthenium compounds have been found to have biological activity and this has led to growing interest in finding potential ruthenium-based drugs for various diseases. Researchers have been exploring these bioactive properties of ruthenium complexes as potential antimicrobial, anticancer and antiviral agents [46][47][48][49][50][51]. Even though ruthenium does not have any specific biochemical role, it has been observed to show low toxicity in biological systems [49].…”

Section: Ruthenium Compounds As Antimicrobial Agentsmentioning

confidence: 99%

Untitled

2022

J. Med. Chem. Sci.

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Interaction and Binding Modes of bis-Ruthenium(II) Complex to Synthetic DNAs

Cited by 6 publications

References 35 publications

Antibacterial Activity of 2-Picolyl-polypyridyl-Based Ruthenium (II/III) Complexes on Non-Drug-Resistant and Drug-Resistant Bacteria

Antibacterial Activity of 2-Picolyl-polypyridyl-Based Ruthenium (II/III) Complexes on Non-Drug-Resistant and Drug-Resistant Bacteria

Synthesis of Mixed Ligand Ruthenium (II/III) Complexes and Their Antibacterial Evaluation on Drug-Resistant Bacterial Organisms

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