Interaction and toxicity of ingested nanoparticles on the intestinal barrier

Stalder, Thomas; Zaiter, Taghrid; Basset, Wassim El; Cornu, Raphaël; Martin, Hélène; Diab, Mona; Béduneau, Arnaud

doi:10.1016/j.tox.2022.153353

Cited by 11 publications

(3 citation statements)

References 129 publications

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“…The turnover of GI mucus is reported to be 24–48 h in humans; therefore, the advantages of a mucoadhesive nanoparticulate drug delivery system would appear in humans rather than rats. For the clinical application of mDDS formulations, there still remains safety concerns to be addressed since orally taken cationic polymeric NPs could trigger cell death and/or toxic responses (Hwang et al., 2015; Stalder et al., 2022; Wei et al., 2015). In the present study, the toxic potential of prepared NCs was assessed in terms of inflammatory symptoms including intestinal bleeding, infiltration of inflammatory cells, thickening of the submucosa, and destruction of GI epithelial tissues.…”

Section: Resultsmentioning

confidence: 99%

Pharmacokinetic control of orally dosed cyclosporine A with mucosal drug delivery system

Yamada,

Ristroph,

Kaneko

et al. 2024

Biopharm & Drug Disp

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This study aimed to control the oral absorption of cyclosporine A (CsA) with the use of a mucosal drug delivery system (mDDS). Mucopenetrating nanocarriers (MP/NCs) and mucoadhesive nanocarriers (MA/NCs) were prepared by flash nanoprecipitation employing polystyrene‐block‐poly(ethylene glycol) and polystyrene‐block‐poly(N,N‐dimethyl aminoethyl methacrylate), respectively. Their particle distribution in the rat gastrointestinal tract were visualized by fluorescent imaging. Plasma concentrations were monitored after oral administration of CsA‐loaded MP/NCs (MP/CsA) and MA/NCs (MA/CsA) to rats. MP/NCs and MA/NCs had a particle size below 200 nm and ζ‐potentials of 4 and 40 mV, respectively. The results from in vitro experiments demonstrated mucopenetration of MP/NCs and mucoadhesion of MA/NCs. Confocal laser scanning microscopic images showed diffusion of MP/NCs in the gastrointestinal mucus towards epithelial cells and localization of MA/NCs on the surface of the gastrointestinal mucus layer. In a pH 6.8 solution, rapid and sustained release of CsA were observed for MP/CsA and MA/CsA, respectively. After oral dosing (10 mg‐CsA/kg) to rats, amorphous CsA powder exhibited a time to maximum plasma concentration (Tmax) of 3.4 h, maximum plasma concentration (Cmax) of 0.12 μg/mL, and bioavailability of 0.7%. Compared with amorphous CsA powder, MP/CsA shortened Tmax by 1.1 to 2.3 h and increased the bioavailability by 43‐fold to 30.1%, while MA/CsA prolonged Tmax by 3.4 to 6.8 h with Cmax and bioavailability of 0.65 μg/mL and 11.7%, respectively. These pharmacokinetic behaviors would be explained by their diffusion and release properties modulated by polymeric surface modification. The mDDS approach is a promising strategy for the pharmacokinetic control of orally administered CsA.

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Section: Resultsmentioning

confidence: 99%

Pharmacokinetic control of orally dosed cyclosporine A with mucosal drug delivery system

Yamada,

Ristroph,

Kaneko

et al. 2024

Biopharm & Drug Disp

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“…It becomes imperative to investigate the nanoparticles' capacity to elicit an innate immune response. Various nanoparticles, including metal and metal-oxide nanoparticles, have been reported to induce pro-inflammatory effects in both in vitro and in vivo studies [ 134 , 135 ].…”

Section: Challenges and Toxicity Profiles Associated With Bio-synthes...mentioning

confidence: 99%

A comprehensive review on Moringa oleifera nanoparticles: importance of polyphenols in nanoparticle synthesis, nanoparticle efficacy and their applications

Perumalsamy,

Balusamy,

Sukweenadhi

et al. 2024

J Nanobiotechnol

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Moringa oleifera is one of the popular functional foods that has been tremendously exploited for synthesis of a vast majority of metal nanoparticles (NPs). The diverse secondary metabolites present in this plant turn it into a green tool for synthesis of different NPs with various biological activities. In this review, we discussed different types of NPs including silver, gold, titanium oxide, iron oxide, and zinc oxide NPs produced from the extract of different parts of M. oleifera. Different parts of M. oleifera take a role as the reducing, stabilizing, capping agent, and depending on the source of extract, the color of solution changes within NP synthesis. We highlighted the role of polyphenols in the synthesis of NPs among major constituents of M. oleifera extract. The different synthesis methods that could lead to the formation of various sizes and shapes of NPs and play crucial role in biomedical application were critically discussed. We further debated the mechanism of interaction of NPs with various sizes and shapes with the cells, and further their clearance from the body. The application of NPs made from M. oleifera extract as anticancer, antimicrobial, wound healing, and water treatment agent were also discussed. Small NPs show better antimicrobial activity, while they can be easily cleared from the body through the kidney. In contrast, large NPs are taken by the mono nuclear phagocyte system (MPS) cells. In case of shape, the NPs with spherical shape penetrate into the bacteria, and show stronger antibacterial activity compared to the NPs with other shapes. Finally, this review aims to correlate the key characteristics of NPs made from M. oleifera extract, such as size and shape, to their interactions with the cells for designing and engineering them for bio-applications and especially for therapeutic purposes. Graphical Abstract

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“…The possibility that biological effects of nanomaterials may be mediated by alterations in microbiota composition has been proposed several years ago [ 82 ] and recently reviewed [ 83 ]. The first studies on the possible interaction of ASNP with intestinal microbiota were performed in 2015 in rats [ 84 ], where no significant changes in the qualitative and quantitative composition of the intestinal microbiota populations were described.…”

Section: Interaction With Microbiota: Evidence From Studies On Mammal...mentioning

confidence: 99%

Amorphous silica nanoparticles and the human gut microbiota: a relationship with multiple implications

Bianchi,

Chiu,

Taurino

et al. 2024

J Nanobiotechnol

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Amorphous silica nanoparticles (ASNP) are among the nanomaterials that are produced in large quantities. ASNP have been present for a long time in several fast-moving consumer products, several of which imply exposure of the gastrointestinal tract, such as toothpastes, food additives, drug excipients, and carriers. Consolidated use and experimental evidence have consistently pointed to the very low acute toxicity and limited absorption of ASNP. However, slow absorption implies prolonged exposure of the intestinal epithelium to ASNP, with documented effects on intestinal permeability and immune gut homeostasis. These effects could explain the hepatic toxicity observed after oral administration of ASNP in animals. More recently, the role of microbiota in these and other ASNP effects has attracted increasing interest in parallel with the recognition of the role of microbiota in a variety of conditions. Although evidence for nanomaterial effects on microbiota is particularly abundant for materials endowed with bactericidal activities, a growing body of recent experimental data indicates that ASNPs also modify microbiota. The implications of these effects are recounted in this contribution, along with a discussion of the more important open issues and recommendations for future research. Graphical Abstract

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Interaction and toxicity of ingested nanoparticles on the intestinal barrier

Cited by 11 publications

References 129 publications

Pharmacokinetic control of orally dosed cyclosporine A with mucosal drug delivery system

Pharmacokinetic control of orally dosed cyclosporine A with mucosal drug delivery system

A comprehensive review on Moringa oleifera nanoparticles: importance of polyphenols in nanoparticle synthesis, nanoparticle efficacy and their applications

Amorphous silica nanoparticles and the human gut microbiota: a relationship with multiple implications

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