Interaction behaviors and structural characteristics of zein/NaTC nanoparticles

Wang, Xiaoyong; Fan, Min

doi:10.1039/c9ra00005d

Cited by 22 publications

(15 citation statements)

References 34 publications

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“…On the other hand, Bosaeus et al [88] investigated soy bean proteins as alternatives to meat proteins and did not find significant influences on ileostomy bile acid concentrations. A recent study of Wang and Fan [89] focused on structural characteristics of the interaction between zein, a plant protein isolated from maize, and sodium taurocholate. The study showed sodium taurocholate-dependent changes in secondary and tertiary protein structures and electrostatic binding between the bile salt and the protein.…”

Section: Interactions Between Bile Acids and Proteinsmentioning

confidence: 99%

Mechanisms of Interactions between Bile Acids and Plant Compounds—A Review

Naumann

Haller

Eisner

et al. 2020

IJMS

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Plant compounds are described to interact with bile acids during small intestinal digestion. This review will summarise mechanisms of interaction between bile acids and plant compounds, challenges in in vivo and in vitro analyses, and possible consequences on health. The main mechanisms of interaction assume that increased viscosity during digestion results in reduced micellar mobility of bile acids, or that bile acids and plant compounds are associated or complexed at the molecular level. Increasing viscosity during digestion due to specific dietary fibres is considered a central reason for bile acid retention. Furthermore, hydrophobic interactions are proposed to contribute to bile acid retention in the small intestine. Although frequently hypothesised, no mechanism of permanent binding of bile acids by dietary fibres or indigestible protein fractions has yet been demonstrated. Otherwise, various polyphenolic structures were recently associated with reduced micellar solubility and modification of steroid and bile acid excretion but underlying molecular mechanisms of interaction are not yet fully understood. Therefore, future research activities need to consider the complex composition and cell-wall structures as influenced by processing when investigating bile acid interactions. Furthermore, influences of bile acid interactions on gut microbiota need to be addressed to clarify their role in bile acid metabolism.

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Section: Interactions Between Bile Acids and Proteinsmentioning

confidence: 99%

Mechanisms of Interactions between Bile Acids and Plant Compounds—A Review

Naumann

Haller

Eisner

et al. 2020

IJMS

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“…The use of UV-Vis absorption, fluorescence and circular dichroism have shed light on the interactions between zein and NaTC at submicellar BS concentration. The combination of techniques showed that protein undergoes conformational changes in the secondary and tertiary structure in the mixed protein-BS aggregate above certain NaTC concentration [69]. The experimental procedure was carried out at pH 4, at which electrostatic binding is likely to occur between positively charged zein nanoparticles (NPs) (IP at pH 6.2) and negatively charged NaTC.…”

Section: Bs and Proteinsmentioning

confidence: 99%

Bile salts in digestion and transport of lipids

Macierzanka

Torcello‐Gómez

Jungnickel

et al. 2019

Advances in Colloid and Interface Science

132

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“…This study investigated the interaction between bile salts and hydrophilic pharmaceutical grade polymers with the aim to contribute new insights into the impacts of bile salt-polymer interaction on drug solubilisation. Such knowledge would benefit the further exploitation of solid dispersions in the delivery of poorly water-soluble drugs 4 Bile salts are produced by the oxidation of cholesterol in the liver, stored in the gallbladder and excreted into the intestinal lumen, [18] and have been shown to interact with different kind of drug delivery systems, such as β-Cyclodextrins, [19,20] zein protein [21] and gold nanoparticles. [22] They have a rigid tetracyclic steroid ring structure with the convex side of the ring being hydrophobic and the concave side of the ring being hydrophilic.…”

Section: Introductionmentioning

confidence: 99%

Probing the molecular interactions between pharmaceutical polymeric carriers and bile salts in simulated gastrointestinal fluids using NMR spectroscopy

Pigliacelli

Belton

Wilde

et al. 2019

Journal of Colloid and Interface Science

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The number of poorly soluble new drugs is increasing and one of the effective ways to deliver such pharmaceutically active molecules is using hydrophilic polymers to form a solid dispersion. Bile salts play an important role in the solubilisation of poorly soluble compounds in the gut prior to absorption. When a poorly water-soluble drug is delivered using a hydrophilic polymer based solid dispersion oral formulation, it is still unclear whether there are any polymer-bile salt interactions, which may influence the drug dissolution and solubilisation. This study, using two widely used hydrophilic model polymers, Hydroxypropyl methylcellulose (HPMC) and polyvynilpirrolidone (PVP), and sodium taurocholate (NaTC) as the model bile salt, aims to investigate the interactions between the polymers and bile salts in simulated fed state (FeSSIF) and fasted state (FaSSIF) gut fluids. The nature of the interactions was characterised using a range of NMR techniques. The results revealed that the aggregation behaviour of NaTC in FaSSIF and FeSSIF is much more complex than in water. The addition of hydrophilic polymers led to the occurrences of NaTC-HPMC and NaTC-PVP aggregation. For both systems, pH and ionic strength strongly influenced the aggregation behavior, while the ion type played a less significant role. The outcome of this study enriched the understanding of the aggregation behaviour of bile salts and typical hydrophilic pharmaceutical polymers in bio-relevant media. Due to the highly surfaceactive behaviour of the bile salts, such aggregation behaviour is expected to play a role in drug solubilisation in the gut when the drug is delivered by hydrophilic polymer based dispersions.

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Interaction behaviors and structural characteristics of zein/NaTC nanoparticles

Abstract: Bile salts are biosurfactants distributed in the human gastrointestinal tract, which can significantly influence the structure and functions of orally administrated components.

Cited by 22 publications

References 34 publications

Mechanisms of Interactions between Bile Acids and Plant Compounds—A Review

Mechanisms of Interactions between Bile Acids and Plant Compounds—A Review

Bile salts in digestion and transport of lipids

Probing the molecular interactions between pharmaceutical polymeric carriers and bile salts in simulated gastrointestinal fluids using NMR spectroscopy

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