Interaction between Arsenic Exposure from Drinking Water and Genetic Polymorphisms on Cardiovascular Disease in Bangladesh: A Prospective Case-Cohort Study

Wu, Fen; Jasmine, Farzana; Kibriya, Muhammad G.; Liu, Mengling; Cheng, Xin; Parvez, Faruque; Islam, Tariqul; Ahmed, Alauddin; Rakibuz-Zaman, Muhammad; Jiang, Junyan; Roy, Shantanu; Paul-Brutus, Rachelle; Slavkovich, Vesna; Levy, Diane; VanderWeele, Tyler J.; Pierce, Brandon L.; Ahsan, Habibul; Chen, Yu

doi:10.1289/ehp.1307883

Cited by 33 publications

(33 citation statements)

References 64 publications

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“…Individuals who died before the first follow-up (n=107) were excluded, leaving a total of 11,639 subjects. Among these, we focused only on those on whom we had obtained a blood sample and had genotyped as part of a previous case-cohort study (n=1804) [11,19]. We excluded 553 individuals who did not have a baseline well water As measurement, in addition to 3 individuals who did not have a BP measurement at baseline and 69 without at least one follow-up BP measurements.…”

Section: Methodsmentioning

confidence: 99%

Gene–arsenic interaction in longitudinal changes of blood pressure: Findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh

Farzan

Jiang

et al. 2015

Toxicology and Applied Pharmacology

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Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide and mounting evidence indicates that toxicant exposures can profoundly impact on CVD risk. Epidemiologic studies have suggested that arsenic (As) exposure is positively related to increases in blood pressure (BP), a primary CVD risk factor. However, evidence of whether genetic susceptibility can modify the association between As and BP are lacking. In this study, we used mixed effects models adjusted for potential confounders to examine the interaction between As exposure from well water and potential genetic modifiers on longitudinal change in BP over approximately 7 years of follow-up in 1137 subjects selected from the Health Effects of Arsenic Longitudinal Study (HEALS) cohort in Bangladesh. Genotyping was conducted for 235 SNPs in 18 genes related to As metabolism, oxidative stress and endothelial function. We observed interactions between 44 SNPs with well water As for one or more BP outcome measures (systolic, diastolic, or pulse pressure (PP)) over the course of follow-up. The interaction between CYBA rs3794624 and well water As on annual PP remained statistically significant after correction for multiple comparisons (FDR-adjusted p for interaction = 0.05). Among individuals with the rs3794624 variant genotype, well water As was associated with a 2.23 mmHg (95% CI: 1.14-3.32) greater annual increase in PP, while among those with the wild type, well water As was associated with a 0.13 mmHg (95% CI: 0.02-0.23) greater annual increase in PP. Our results suggest that genetic variability may contribute to As-associated increases in BP over time.

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Section: Methodsmentioning

confidence: 99%

Gene–arsenic interaction in longitudinal changes of blood pressure: Findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh

Farzan

Jiang

et al. 2015

Toxicology and Applied Pharmacology

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“…Additionally, endothelial dysfunction associated with arsenic exposure has also been observed. In Bangladesh, gene by environment interaction in relation to increases in blood pressure from arsenic exposure has been well described, demonstrating variable cardiotoxicity due to variable methylation of arsenic 149–151 . In a separate Bangladesh study, folate supplementation promoted urinary excretion of arsenic and may attenuate arsenic toxicity 201 .…”

Section: Arsenicmentioning

confidence: 99%

Environmental Exposures and Cardiovascular Disease

2017

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Summary Environmental exposures in low- and middle-income countries lie at the intersection of increased economic development and the rising public health burden of cardiovascular disease. Increasing evidence suggests an association of exposure to ambient air pollution, household air pollution from biomass fuel, lead, arsenic, and cadmium with multiple cardiovascular disease outcomes including hypertension, coronary heart disease, stroke, and cardiovascular mortality. While populations in low- and middle-income countries are disproportionately exposed to environmental pollution, the bulk of evidence that links these exposures to cardiovascular disease is derived from populations in high-income countries. More research is needed to further characterize the extent of environmental exposures and develop targeted interventions towards reducing cardiovascular disease in at-risk populations in low- and middle-income countries.

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“…Ponadto badania przeprowadzone w Bangladeszu wykazały związek polimorfizmów genów kodujących białka związane z metabolizmem arsenu, stresem oksydacyjnym, procesem zapalnym i dysfunkcją śródbłonka z występowaniem chorób kardiologicznych w następstwie narażenia na arsen [15].…”

Section: Arsen (As)unclassified

Polymorphism of genes encoding proteins of DNA repair vs. occupational and environmental exposure to lead, arsenic and pesticides

Bukowski¹,

Woźniak²

2017

Med Pr

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StreszczeniePolimorfizm genetyczny wiąże się z występowaniem w populacji co najmniej 2 różnych alleli w danym locus z częstością większą niż 1%. Wyróżniamy m.in. polimorfizm pojedynczego nukleotydu (single nucleotide polymorphism -SNP) i polimorfizm zmiennej liczby powtórzeń tandemowych. Występowanie określonych polimorfizmów w genach kodujących enzymy naprawy DNA jest związane z szybkością i wydajnością naprawy DNA oraz może chronić lub narażać daną osobę na skutki działania określonego ksenobiotyku. Związki chemiczne takie, jak ołów, arsen i pestycydy odznaczają się dużą toksycznością. Opisano wiele różnych polimorfizmów genów kodujących enzymy naprawy DNA, które mają wpływ na skuteczność naprawy uszkodzeń DNA indukowanych przez te ksenobiotyki. W przypadku ołowiu zbadano wpływ polimorfizmów genów: APE1 (apurinic/apyrimidinic endonuclease 1 -endonukleaza miejsca apurynowego/apirymidynowego) (rs1130409), hOGG1 (human 8-oxoguanine glycosylase -glikozylaza 8-oksyguaniny) (rs1052133), XRCC1 (X-ray repair cross-complementing protein group 1 -białko biorące udział w naprawie DNA przez wycinanie zasad) (rs25487), XRCC1 (rs1799782) oraz XRCC3 (X-ray repair cross-complementing protein group 3 -białko biorące udział w naprawie DNA przez rekombinację homologiczną) (rs861539). Dla arsenu przedstawiono w niniejszej pracy wyniki badań dotyczących następujących polimorfizmów: ERCC2 (excision repair cross-complementingbiałko biorące udział w naprawie DNA przez wycinanie nukleotydów) (rs13181), XRCC3 (rs861539), APE1 (rs1130409) oraz hOGG1 (rs1052133). W odniesieniu do pestycydów w pracy przedstawiono zarówno osobny, jak i łączny wpływ polimorfizmów genów takich, jak XRCC1 (rs1799782), hOGG1 (rs1052133), XRCC4 (X-ray repair cross-complementing protein group 4 -białko biorące udział w naprawie DNA przez łączenie końców niehomologicznych) (rs28360135) i genu kodującego enzym detoksykacyjny paraoksonazę PON1 (paraoxonase 1) (rs662). Med. Pr. 2018;69(2):225-235 Słowa kluczowe: polimorfizm genetyczny, arsen, pestycydy, ołów, uszkodzenia DNA, geny naprawy DNA AbstractGenetic polymorphism is associated with the occurrence of at least 2 different alleles in the locus with a frequency higher than 1% in the population. Among polymorphisms we can find single nucleotide polymorphism (SNP) and polymorphism of variable number of tandem repeats. The presence of certain polymorphisms in genes encoding DNA repair enzymes is associated with the speed and efficiency of DNA repair and can protect or expose humans to the effects provoked by xenobiotics. Chemicals, such as lead, arsenic pesticides are considered to exhibit strong toxicity. There are many different polymorphisms in genes encoding DNA repair enzymes, which determine the speed and efficiency of DNA damage repair induced by these xenobiotics. In the case of lead, the influence of various polymorphisms, such as APE1 (apurinic/apyrimidinic endonuclease 1) (rs1130409), hOGG1 (human 8-oxoguanine glycosylase) (rs1052133), XRCC1 (X-ray repair cross-complementing protein group 1) (rs25487), X...

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Interaction between Arsenic Exposure from Drinking Water and Genetic Polymorphisms on Cardiovascular Disease in Bangladesh: A Prospective Case-Cohort Study

Cited by 33 publications

References 64 publications

Gene–arsenic interaction in longitudinal changes of blood pressure: Findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh

Gene–arsenic interaction in longitudinal changes of blood pressure: Findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh

Environmental Exposures and Cardiovascular Disease

Polymorphism of genes encoding proteins of DNA repair vs. occupational and environmental exposure to lead, arsenic and pesticides

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