Interaction Between CETP Taq1B Polymorphism and Dietary Patterns on Lipid Profile and Severity of Coronary Arteries Stenosis in Patients under Coronary Angiography: A Cross Sectiona Study

Abstract

Aim: Evidence indicates there are still conflicts regarding CETP Taq1B polymorphism and coronary artery disease risk factors. Current knowledge about whether dietary patterns can change the relationship of the Taq1B on lipid profile and the severity of coronary arteries stenosis is limited. Present research aimed to investigate this hypothesis. Methods: This cross-sectional study involved 453 male and female participants, with a mean age of 57 years. A validated 178-item food frequency questionnaire ( FFQ ) used to assess dietary usual intake. Dietary patterns extracted through principal component analysis (PCA). Taq1B variant genotyped by the polymerase chain reaction-restriction fragment length polymorphism method. Two-way ANOVA was used to test the interaction between Taq1B polymorphism and dietary patterns. Results: Two dietary patterns were detected: the western dietary pattern (WDP) and the traditional dietary pattern (TDP). The frequency of Taq1B genotypes was 10.4, 72.4, and 17.2% for B1B1, B1B2, and B2B2, respectively. Carriers of the B2 allele who adhered highly to either TDP or WDP had lower levels of TG and a lower ratio of TG to HDL-C. Taq1B had a significant interaction with TDP for modulating TG in both unadjusted and adjusted models (P = 0.04 and P = 0.02, respectively), and also in TG/HDL-C ratio in the adjustment model (P = 0.04). No significant difference or interaction observed in the other variables among Taq1B genotypes and diets. Conclusion: TDP may alter the relationship between CETP Taq1B and TG and TG/HDL among subjects under coronary angiography. Longitudinal and interventional studies suggest for a better understanding of the role of diets and Taq1B variant in cardio-metabolic risk factors.