Interaction between chlorhexidine and fluoride in a mouthrinse solution—a 4-day and 6-week randomized clinical pilot study

Abstract

A mouthrinse solution containing a mixture of CHX and NaF may be an interesting product for risk patients for caries and periodontal disease. However, this should be verified in further long-term clinical studies.

Will a chlorhexidine‐fluoride mouthwash reduce plaque and gingivitis?

“…Five studies (V, VI, VII, VIII, IXb) used the MW as an adjunct to self‐performed daily oral hygiene; the duration ranged from 7 days to 6 months. The non‐brushing experimental gingivitis model over 21 days was used in 2 studies (III, IV) providing 4 comparisons.…”

“…The non‐brushing experimental gingivitis model over 21 days was used in 2 studies (III, IV) providing 4 comparisons. Three non‐brushing studies (I, II, IXa) used de novo plaque accumulation for 4, 7 or 11 days. All included studies were RCTs, 5 used a crossover design (I, II, III, IXa+b) and 5 used a parallel design (IV, V, VI, VII, VIII).…”

“…Three non‐brushing studies (I, II, IXa) used de novo plaque accumulation for 4, 7 or 11 days. All included studies were RCTs, 5 used a crossover design (I, II, III, IXa+b) and 5 used a parallel design (IV, V, VI, VII, VIII). All studies (except VI, VII) provide a professional prophylaxis to remove plaque, stain and calculus at baseline.…”

“…All studies included participants in good general health. The study populations in the studies I, II, III, IV, IXa+b were dental (hygiene) students, study V selected medical students and VIII a combination. Regarding periodontal health, the following definitions, criteria and diagnoses were used for inclusion: pockets ≤4 mm (III), a gingival index (GI) ≤0.5 (IV) or <1.5 (V), no signs of destructive periodontitis (II, VIII) and good gingival health (I).…”

“…The majority of the clinical studies do not mention information regarding smoking status. Only one (IV) reported the smoking status, but it was not analysed further and 3 clinical trials (VII and IXa+B) specifically excluded smokers.…”