Interaction between ciclopirox and acenocoumarol

Morales-Molina, José Antonio; Pérez-Moyano, Rosario; Fayet-Perez, A; Urquizar-Rodriguez, O; Giménez-López, María José

doi:10.1007/s00228-012-1347-x

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Cpx As An Antifungal Agent1

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Cited by 3 publications

(1 citation statement)

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“…Other adverse effects include headache, erythema, nail disorder, pruritus, alopecia, dry skin, facial oedema, and contact dermatitis [19]. Recently, it has been reported that in elderly patients treated with acenocoumarol, an anticoagulant that inhibits vitamin K epoxide reductase, topical use of CPX can increase International Normalized Ratio or cause rectal bleeding [38]. This has been speculated to be due to a possible interaction between CPX with acenocoumarol [38].…”

Section: Cpx As An Antifungal Agentmentioning

confidence: 99%

Repositioning the Old Fungicide Ciclopirox for New Medical Uses

Shen¹,

Huang

2016

CPD

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Section: Cpx As An Antifungal Agentmentioning

confidence: 99%

Repositioning the Old Fungicide Ciclopirox for New Medical Uses

Shen¹,

Huang

2016

CPD

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Acenocoumarol/ciclopirox interaction

2013

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Old and new oral anticoagulants: Food, herbal medicines and drug interactions

et al. 2017

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The most commonly prescribed oral anticoagulants worldwide are the vitamin K antagonists (VKAs) such as warfarin. Factors affecting the pharmacokinetics of VKAs are important because deviations from their narrow therapeutic window can result in bleedings due to over-anticoagulation or thrombosis because of under-anticoagulation. In addition to pharmacodynamic interactions (e.g., augmented bleeding risk for concomitant use of NSAIDs), interactions with drugs, foods, herbs, and over-the-counter medications may affect the risk/benefit ratio of VKAs. Direct oral anticoagulants (DOACs) including Factor Xa inhibitors (rivaroxaban, apixaban and edoxaban) and thrombin inhibitor (dabigatran) are poised to replace warfarin. Phase-3 studies and real-world evaluations have established that the safety profile of DOACs is superior to those of VKAs. However, some pharmacokinetic and pharmacodynamic interactions are expected. Herein we present a critical review of VKAs and DOACs with focus on their potential for interactions with drugs, foods, herbs and over-the-counter medications.

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Interaction between ciclopirox and acenocoumarol

Cited by 3 publications

References 5 publications

Repositioning the Old Fungicide Ciclopirox for New Medical Uses

Repositioning the Old Fungicide Ciclopirox for New Medical Uses

Acenocoumarol/ciclopirox interaction

Old and new oral anticoagulants: Food, herbal medicines and drug interactions

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