Interaction between dopamine and glutamate in the sensorimotor cortex during conditioned placing reaction

Storozhuk, V. M.; Sanzharovsky, A.V; Busel, B. I.

doi:10.1016/s0306-4522(97)00643-x

Cited by 9 publications

(6 citation statements)

References 32 publications

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“…Whether this effect is mediated by reduced cellular excitability or via depression of synaptic transmission remains unclear. Although most studies show an inhibitory effect of DA, sporadic reports describe enhanced cellular excitability after DA application (Sawaguchi et al, 1986;Penit-Soria et al, 1987;Storozhuk et al, 1998). This discrepancy may be explained by methodological differences, e.g.…”

Section: Modulation Of Sep Amplitudes By D1 and D2 Receptorsmentioning

confidence: 99%

Dopaminergic modulation of receptive fields in rat sensorimotor cortex

et al. 2011

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Section: Modulation Of Sep Amplitudes By D1 and D2 Receptorsmentioning

confidence: 99%

Dopaminergic modulation of receptive fields in rat sensorimotor cortex

et al. 2011

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“…In most works on this trend, the reactions to stimuli without reinforcement were not specially studied, but instead were only compared to responses to the activating conditioned stimulus. Analysis of the dynamics of neuron action potentials showed low intensity or an opposite sign of reactions to the stimuli without reinforcement compared to those to activating reinforced stimuli (Albrecht, Davidova, & Gabriel, 1990;Farley & Alkon, 1985;Freeman & Nicholson, 1999;Fuster & Alexander, 1971;Horn, 1967;Jasper, Ricci, & Doane, 1960;Kubota, Wolske, Poremba, Kang, & Gabriel, 1974;Kubota, Yamamoto, & Suzuki, 1996;Morrell, 1960;Powel, Watson, & Buchman, 1990;Rabinovich, 1975;Repa et al, 2001,.;Shulgina, 1969Shulgina, , 1976Shulgina, , 1978Storozhuk, Sanzharovsky, & Busel, 1998;Tshizhenkova, 1998;Watanabe, 1986). Some works demonstrated the presence of neurons with a more intensive response to the inhibitory stimulus than to the positive stimulus.…”

Section: Changes In the Quantitative Structure And Intensity Of Neuromentioning

confidence: 99%

The Neurophysiological Validation of the Hyperpolarization Theory of Internal Inhibition

Shul'gina

2005

Span. J. Psychol.

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The experiments in conscious non-immobilized rabbits showed that cessation of the reactions without reinforcement (elaboration of the internal inhibition) is accompanied by an enhanced phasic state, by alternation of activation and inhibition of neuron firing, and by the corresponding slow potential oscillation (SPO). These changes can be either localized, predominantly in the structures of conditioned stimulus, or, under enhancement of the inhibitory state, generalized in the brain structures. On the basis of our experience and published data, it is concluded that the above event results from relative enhancement of the inhibitory hyperpolarizing processes due to increase in reactivity of the inhibitory systems to stimulus, which acquires inhibitory properties during learning. Changes in the excitability and reactivity of neuron populations appearing during enhancement of the hyperpolarizing inhibition, and differing in the various brain structures, play an active role in the execution of the main function of the internal inhibition: limitation of excitation transmission to the effectors. An inhibitory mediator gamma aminobutyric acid (GABA) is of great importance in inhibiting the excitation in response to the stimulus which lost its biological significance. These experimental data and their interpretation in the light of published data give the basis for the development of the hyperpolarization theory of internal inhibition. Keywords: psychophysiology of behavior, learning, internal inhibition, latent inhibition, gamma aminobutyric acidEn los experimentos con conejos conscientes no inmovilizados se ha mostrado que la interrupción de las reacciones tras la supresión del refuerzo, es decir, la elaboración de la inhibición interna, se ve acompañada por el incremento de fases, la alternancia de la activación y la inhibición del disparo de las neuronas, y sus correspondientes oscilaciones lentas de potencial. Estos cambios pueden ser locales, principalmente en las estructuras del estímulo condicionado o, en caso de incremento del estado de inhibición, generalizados sobre las estructuras del cerebro. Basándonos en nuestros datos y en los de la literatura actual se llega a la conclusión de que ese fenómeno está condicionado por el incremento de los procesos inhibitorios de hiperpolarización a raíz del incremento de la reactividad de los sistemas inhibitorios de la acción del estímulo, que adquiere significado inhibitorio durante el proceso de aprendizaje. La oscilación de la excitabilidad y reactividad en las poblaciones de elementos nerviosos que surge durante el incremento de la inhibición de la hiperpolarización, divergentes en distintas estructuras del cerebro, juega un papel activo en la ejecución de la función básica de la inhibición interna, la limitación de la transmisión de la excitación a los efectores. El mediador inhibidor, el ácido gama aminobutírico (GABA), juega un papel esencial en la desarrollo de la inhibición de la excitación al estímulo que ha perdido su significado biológico. Estos datos experim...

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“…×åðåç 1012 ä³á ï³ñëÿ õ³ðóðã³÷í î ã î â ò ð ó ÷ à í í ÿ ï î ÷ è í à ë è ð å º ñ ò ð à ö ³ þ ³ìïóëüñíî¿ àêòèâíî ñò³ â³ä ïîîäèíîêèõ íåéðîí³â ñîìàòîìîòîðíî¿ êîðè çà äîïîìîãîþ òðèñòîâáóðíèõ ñêëÿíèõ ì³êðîï³ïåòîê ç ç à ã à ë ü í è ì ä ³ à ì å ò ð î ì ê ³ í ÷ è ê à 5 ì ê ì . Ñòîâáóð äëÿ ðåºñòðàö³¿ çàïîâíþâàëè 3 Ì NaCl, à äâà ³íøèõ, ÿê³ âèêîðèñòîâóâàëè äëÿ ì³êðîàïë³êàö³¿ ôàðìàêîëîã³÷íèõ ðå÷îâèí ³îíîôîðåç³óì, çàïîâíþâàëè L-ÄÎÔÀ (0,5 ìîëü/ë, pH 4,0) òà êåòàì³íîì (0,18 ìîëü/ë, pH 5 Àïë³êàö³ÿ L-ÄÎÔÀ ó îêðåìî âçÿòèõ ê³ðêîâèõ íåéðîí³â âèêëèêàëà çíà÷í³ çì³íè ôîíîâî¿ ³ìïóëüñíî¿ àêòèâíîñò³ ó âèãëÿä³ çá³ëüøåííÿ ÷àñòîòè ðîçðÿä³â, íà ùî âêàçóþòü ³íø³ àâòîðè [24]. Ñåðåäíÿ ÷àñòîòà ðîçðÿä³â ôîíîâî¿ ³ìïóëüñíî¿ àêòèâíîñò³ âñ³õ äîñë³äaeåíèõ íåéðîí³â ïðè ä³¿ L-ÄÎÔÀ çá³ëüøóâàëàñÿ íà 18 %, ç 9,2±1,7 äî 11,0 ³ìï./ñ ± 1,6 ³ìï./ñ (Ð>0,05).…”

Section: ìåòîäèêàunclassified

“…Â³äîìî, ùî ì³êðî³îíîôîðåç L-ÄÎÔÀ äî ïîîäèíîêèõ íåéðîí³â ñîìàòîìîòîðíî¿ êîðè â óìîâàõ, ïîä³áíèõ äî âèêîðèñòàíî¿ â ö³é ðîáîò³ åêñïåðèìåíòàëüíî¿ ïðîöåäóðè, ìîaeå ñïðè÷èíÿòè ÿê ïîëåãøóâàëüíèé, òàê ³ ïðèãí³÷óâàëüíèé åôåêòè [24]. Ïîä³áíà ð³çíîñïðÿìîâàí³ñòü áóëà âñòàíîâëåíà i â äîñë³äaeåí³é ñóêóïíîñò³ ê³ðêîâèõ íåéðîí³â.…”

Section: îáãîâîðåííß ðåçóëüòàò²âunclassified

Effect of iontophoretically administered L-DOPA and ketamin on the impulse activity of the somatomotor cortex neurons during the conditioned placing movements

Khorievin¹

2010

Fiziol Zh

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Interaction between dopamine and glutamate in the sensorimotor cortex during conditioned placing reaction

Cited by 9 publications

References 32 publications

Dopaminergic modulation of receptive fields in rat sensorimotor cortex

Dopaminergic modulation of receptive fields in rat sensorimotor cortex

The Neurophysiological Validation of the Hyperpolarization Theory of Internal Inhibition

Effect of iontophoretically administered L-DOPA and ketamin on the impulse activity of the somatomotor cortex neurons during the conditioned placing movements

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