Interaction between gamma-aminobutyric acid type A (GABAA) receptor agents and scopolamine in the nucleus accumbens on impairment of inhibitory avoidance memory performance in rat

Azizbeigi, Ronak; Zarrindast, Mohammad Reza; Ahmadi, Shamseddin

doi:10.1016/j.bbr.2012.12.022

Cited by 10 publications

(3 citation statements)

References 59 publications

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“…Our results showed that post-training intra-CA1 injection of bicuculline had no significant effect on memory consolidation and locomotor activity. In agreement with our data, some reports have shown that injection of bicuculline in to the CA1 (Yousefi et al, 2013), basolateral amygdala (Kangarlu-Haghighi et al, 2015), nucleus accumbens (Azizbeigi et al, 2013), nucleus basalis magnocellularis (Moron et al, 2002), and posterior striatum (Brioni et al, 1990) did not alter memory. Other investigators have reported that blockade of GABA A receptors in the hippocampus through administration of bicuculline improved memory (Chavez et al, 1995, Luft et al, 2004, Yousefi et al, 2012.…”

Section: Discussionsupporting

confidence: 93%

“…There is extensive reports showing that administration of GABAergic agents affect learning and memory retention (Nakagawa and Iwasaki, 1995, Chapouthier and Venault, 2002, Zarrindast et al, 2004, Azizbeigi et al, 2013, Heysieattalab et al, 2015. Evidences indicated that mostly GABAergic agonists impaired memory and their antagonists improved recall (Farr et al, 2000, Chapouthier and Venault, 2002, Ramirez et al, 2005, Zarrindast et al, 2006, Yousefi et al, 2012.…”

Section: Discussionmentioning

confidence: 99%

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Additive effect of harmane and muscimol for memory consolidation impairment in inhibitory avoidance task

Nasehi

Morteza-zadeh²,

Khakpai

et al. 2016

Neuroscience

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In the current study, we examined the effect of bilateral intra-dorsal hippocampal (intra-CA1) microinjections of GABA receptor agents on amnesia induced by a β-carboline alkaloid, harmane in mice. We used a single-trial step-down passive avoidance task to assess memory retention and then, open-field test to assess locomotor activity. The results indicated that post-training intra-CA1 injections of bicuculline - a GABA receptor antagonist - had no significant effect, while muscimol (0.01 and 0.1μg/mouse) - a GABA receptor agonist - impaired memory consolidation. Post-training intra-peritoneal (i.p.) infusion of harmane (3 and 5mg/kg) decreased memory consolidation. Furthermore, post-training intra-CA1 administration of sub-threshold dose of bicuculline (0.001μg/mouse) restored, whereas muscimol (0.001μg/mouse) potentiated impairment of memory consolidation induced by harmane. The isobologram analysis revealed that there is an additive effect between harmane and muscimol on impairment of memory consolidation. Moreover, all above doses of drugs did not alter locomotor activity. These findings suggest that GABA receptors of the CA1 area, at least partly, play a role in modulating the effect of harmane on memory consolidation.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Additive effect of harmane and muscimol for memory consolidation impairment in inhibitory avoidance task

Nasehi

Morteza-zadeh²,

Khakpai

et al. 2016

Neuroscience

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“…Rats received systemic injection of saline or METH and intra‐shell NAc infusions of muscimol (0.005 µg/rat) or bicuculline (0.2 µg/rat, 1 week after systemic injection, Azizbeigi et al, ; Heysieattalab et al, ) prior to baseline recording. The experimental groups were: Saline‐muscimol, METH‐muscimol, Saline‐bicuculline, and METH‐bicuculline (Table ).…”

Section: Methodsmentioning

confidence: 99%

Methamphetamine‐induced enhancement of hippocampal long‐term potentiation is modulated by NMDA and GABA receptors in the shell–accumbens

Heysieattalab

Naghdi

Hosseinmardi

et al. 2016

Synapse

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Addictive drugs modulate synaptic transmission in the meso-corticolimbic system by hijacking normal adaptive forms of experience-dependent synaptic plasticity. Psychostimulants such as METH have been shown to affect hippocampal synaptic plasticity, albeit with a less understood synaptic mechanism. METH is one of the most addictive drugs that elicit long-term alterations in the synaptic plasticity in brain areas involved in reinforcement learning and reward processing. Dopamine transporter (DAT) is one of the main targets of METH. As a substrate for DAT, METH decreases dopamine uptake and increases dopamine efflux via the transporter in the target brain regions such as nucleus accumbens (NAc) and hippocampus. Due to cross talk between NAc and hippocampus, stimulation of NAc has been shown to alter hippocampal plasticity. In this study, we tested the hypothesis that manipulation of glutamatergic and GABA-ergic systems in the shell-NAc modulates METH-induced enhancement of long term potentiation (LTP) in the hippocampus. Rats treated with METH (four injections of 5 mg/kg) exhibited enhanced LTP as compared to saline-treated animals. Intra-NAc infusion of muscimol (GABA receptor agonist) decreased METH-induced enhancement of dentate gyrus (DG)-LTP, while infusion of AP5 (NMDA receptor antagonist) prevented METH-induced enhancement of LTP. These data support the interpretation that reducing NAc activity can ameliorate METH-induced hippocampal LTP through a hippocampus-NAc-VTA circuit loop. Synapse 70:325-335, 2016. © 2016 Wiley Periodicals, Inc.

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Exposure to GSM 900-MHz mobile radiation impaired inhibitory avoidance memory consolidation in rat: Involvements of opioidergic and nitrergic systems

et al. 2018

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Interaction between gamma-aminobutyric acid type A (GABAA) receptor agents and scopolamine in the nucleus accumbens on impairment of inhibitory avoidance memory performance in rat

Cited by 10 publications

References 59 publications

Additive effect of harmane and muscimol for memory consolidation impairment in inhibitory avoidance task

Additive effect of harmane and muscimol for memory consolidation impairment in inhibitory avoidance task

Methamphetamine‐induced enhancement of hippocampal long‐term potentiation is modulated by NMDA and GABA receptors in the shell–accumbens

Exposure to GSM 900-MHz mobile radiation impaired inhibitory avoidance memory consolidation in rat: Involvements of opioidergic and nitrergic systems

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