Interaction between gut microbiota and tumour chemotherapy

Liu, Le; Bai, Yuping; Lin, Xiang; Qi, Wenbo; Gao, Lei; Li, Xiaomei; Li, Haiyuan; Wang, Bofang; Chen, Hao

doi:10.1007/s12094-022-02919-3

Cited by 2 publications

(2 citation statements)

References 67 publications

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“…Gut microbiota have been reported to have either pro- or anti-tumor effects, and regulate not only mucosal but also systemic immune responses [ 33 ]. Previous studies demonstrated that the gut microbiota of cancer patients had interaction effects with chemotherapy drugs [ [34] , [35] , [36] ]. For instance, Bifidobacterium species reduce the adverse effects of chemotherapy by inhibiting proinflammatory cytokines [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Interleukin-2 mediated associations between gut microbiota and acute myeloid leukemia: A population-based mediation Mendelian randomization study

Luo,

Zhang,

Zhu

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Interleukin-2 mediated associations between gut microbiota and acute myeloid leukemia: A population-based mediation Mendelian randomization study

Luo,

Zhang,

Zhu

et al. 2024

Heliyon

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“…Modulating host-microbiota interactions, especially in the gut, which hosts the most rich and diverse microbiota, has emerged as a state-of-the-art therapeutic approach for cancer treatment ( Schwabe and Jobin, 2013 ). Previous studies have shown that the gut microbiota can regulate the sensitivity and responses of cancer patients to chemotherapy ( Liu et al, 2022 ; Rahman et al, 2022 ). Furthermore, alterations in gut microbial structure have been reported to serve as potential indicators for early cancer diagnosis and other diseases ( Sepich-Poore et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Gut microbiota and its therapeutic implications in tumor microenvironment interactions

Feng,

Xue,

Bukhari

et al. 2024

Front. Microbiol.

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The development of cancer is not just the growth and proliferation of a single transformed cell, but its tumor microenvironment (TME) also coevolves with it, which is primarily involved in tumor initiation, development, metastasis, and therapeutic responses. Recent years, TME has been emerged as a potential target for cancer diagnosis and treatment. However, the clinical efficacy of treatments targeting the TME, especially its specific components, remains insufficient. In parallel, the gut microbiome is an essential TME component that is crucial in cancer immunotherapy. Thus, assessing and constructing frameworks between the gut microbiota and the TME can significantly enhance the exploration of effective treatment strategies for various tumors. In this review the role of the gut microbiota in human cancers, including its function and relationship with various tumors was summarized. In addition, the interaction between the gut microbiota and the TME as well as its potential applications in cancer therapeutics was described. Furthermore, it was summarized that fecal microbiota transplantation, dietary adjustments, and synthetic biology to introduce gut microbiota-based medical technologies for cancer treatment. This review provides a comprehensive summary for uncovering the mechanism underlying the effects of the gut microbiota on the TME and lays a foundation for the development of personalized medicine in further studies.

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Interaction between gut microbiota and tumour chemotherapy

Cited by 2 publications

References 67 publications

Interleukin-2 mediated associations between gut microbiota and acute myeloid leukemia: A population-based mediation Mendelian randomization study

Interleukin-2 mediated associations between gut microbiota and acute myeloid leukemia: A population-based mediation Mendelian randomization study

Gut microbiota and its therapeutic implications in tumor microenvironment interactions

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