Interaction between human and simian adenoviruses in simian cells: Complementation, phenotypic mixing and formation of monkey cell “adapted” virions

Altstein, A. D.; Dodonova, N. N.

doi:10.1016/0042-6822(68)90265-1

Cited by 24 publications

(7 citation statements)

References 13 publications

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“…There are several ways to overcome this block. A function that allows human adenovirus to multiply efficiently in simian cells can be provided by coinfecting with simian virus 40 (SV40) (31) or simian adenoviruses (1,30). In addition, this function can be supplied by SV40 DNA that is integrated into the host genome, as in SV40transformed cells (18), or into the infecting human adenovirus genome, as in the Ad2-SV40 hybrid virus Ad2+ND1 (24).…”

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confidence: 99%

Characterization of a variant of human adenovirus type 2 which multiples efficiently in simian cells

Klessig¹,

Hassell²

1978

J Virol

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In a previous report (Klessig, J. Virol. 21:1243-1246, 1977), the isolation of a variant (H2hr400) of adenovirus serotype 2 (Ad2) that overcomes the block to multiplication of wild-type Ad2 in simian cells was described. H2hr400 replicates efficiently on both human and simian cells, resulting in virus yields that are comparable to those found when wild-type Ad2 infects permissive, human cells. An extensive comparison of the genome of H2hr400 with that of its parent by restriction endonuclease, electron microscopic, and hybridization analyses failed to detect any differences and excludes the possibility that simian virus 40 sequences, which in certain Ad2-simian virus 40 hybrid viruses (e.g., Ad2+ND1) allow adenovirus to multiply efficiently in simian cells, are present in H2hr400. In contrast to Ad2, H2hr400 can fully express its late genes in both simian and human cells. The mutation has been mapped by a modified marker rescue technique to the segment of the viral genome located between coordinates 59 and 80.

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confidence: 99%

Characterization of a variant of human adenovirus type 2 which multiples efficiently in simian cells

Klessig¹,

Hassell²

1978

J Virol

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“…However, there is a recent report that phenotypic mixing occurs during mixed infections with simian adenovi rus SA-7 and human adenoviruses in simian cells. Also, it was reported that a defective component was produced that consisted of a "hybrid" of human and simian adenovirus genetic material (73). This conclusion was based on complement fi xation tests which demonstrated the ability of the "hybrid" (which is neutralized by antiserum to human adenovirus) to induce SA-7 T antigen.…”

Section: Rappmentioning

confidence: 98%

“…These include the simian papovavirus SV 40 (49)(50)(51)(52)(53)(54)(62)(63)(64)(65)(66)(67)(68), defective SV40 [ (68)(69)(70), also see Papovavirus section], the defective monkey cell-adapting component (71), and simian adenoviruses (72,73). Other viruses, such as herpes simplex virus and measles virus, were inef fective as helpers (S4).…”

Section: Rappmentioning

confidence: 98%

Defective Dna Animal Viruses

Rapp¹

1969

Annu. Rev. Microbiol.

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“…Although the unrelated simian papovavirus SV40 has most frequently been used as helper virus to enhance the replication of human adenoviruses in monkey cells, simian adenoviruses such as SV15 and SA7 can also supply the helper function (2,21). Temperature-sensitive mutants of SV40 have been used in attempts to determine which cistron of SV40 controls the enhancement of adenovirus replication.…”

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confidence: 99%

Stimulation of adenovirus replication in simian cells in the absence of a helper virus by pretreatment of the cells with iododeoxyuridine

Jerkofsky¹,

Rapp²

1975

J Virol

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Pretreatment of African green monkey kidney cells with 50 ,ug of 5'-iododeoxyuridine (IUdR) per ml can modify their susceptibility to the replication of human adenovirus type 7 in the absence of simian virus 40 (SV40) although this enhancement of adenovirus replication is not as efficient as that of the helper SV40 virus. Since the number of infectious centers remains unchanged after IUdR pretreatment whereas the burst size of virus from each infected cell increases, the IUdR appears to allow each infected cell to produce more virus. Cell DNA synthesis appears to be stimulated in IUdR pretreated cells infected with adenovirus 7, but the host cell DNA synthesized is small enough to remain in the Hirt supernatant fluid. The modification of susceptibility to adenovirus replication and the changed pattern of cell DNA synthesis is stable for at least two additional cell passages of the pretreatled cells.

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Interaction between human and simian adenoviruses in simian cells: Complementation, phenotypic mixing and formation of monkey cell “adapted” virions

Cited by 24 publications

References 13 publications

Characterization of a variant of human adenovirus type 2 which multiples efficiently in simian cells

Characterization of a variant of human adenovirus type 2 which multiples efficiently in simian cells

Defective Dna Animal Viruses

Stimulation of adenovirus replication in simian cells in the absence of a helper virus by pretreatment of the cells with iododeoxyuridine

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