Interaction between obesity and genetic polymorphisms in the apolipoprotein CIII gene and lipoprotein lipase gene on the risk of hypertriglyceridemia in Chinese

Abstract

To understand the effects of the interaction between genetic polymorphisms and obesity on the risk of hypertriglyceridemia (HTG), two polymorphisms, an SstI polymorphism on the apolipoprotein CIII gene and a HindIII polymorphism on the lipoprotein lipase gene, were analyzed in 339 Chinese subjects with (82 cases in the HTG group) or without HTG (257 cases in the control group). Our data revealed that the frequencies of obesity, the SstI minor allele (S2), and the HindIII major allele (H+) in the HTG group were significantly higher than in the control group. Subgroup analysis revealed that the association between these two polymorphisms and HTG occurred predominantly in nonobese subjects and in subjects with the less hypertriglyceridemic genotype of another polymorphism. Multivariate logistic regression analysis showed that all three risk factors (obesity, S2-containing chromosome, and H+ homozygosity) were associated with HTG, and an interaction was found between obesity and H+ homozygosity for the occurrence of HTG. The risk of HTG increased significantly with combinations of risk factors. Subjects can be divided into low or high risk groups for HTG using such combinations. These results provide evidence of interaction between obesity and the HindIII polymorphism of the lipoprotein lipase gene on the risk of HTG.

Lipoprotein lipase gene S447X polymorphism modulates the relation between central obesity and serum lipids, a twin study

“…Although only few studies investigated the interactions between LPL gene polymorphisms and obesity, S447X and HindIII were the mostly reported polymorphisms. [8][9][10][37][38][39] The presence of HindIII polymorphism was reported to be strongly associated with hypertriglyceridemia in obese subjects. [37][38][39] However, results about the interaction of S447X polymorphism and obesity were not consistent but even contrary.…”

“…[8][9][10][37][38][39] The presence of HindIII polymorphism was reported to be strongly associated with hypertriglyceridemia in obese subjects. [37][38][39] However, results about the interaction of S447X polymorphism and obesity were not consistent but even contrary. [8][9][10] Garenc et al 8 showed that the relation between X447 allele and TG only exists in obese subjects (BMI X30), but not in normal-weight subjects (BMI o25).…”

Study of apolipoproteinc3 Sstl polymorphism in healthy volunteers from Northern India

“…Table-2 (18) and French (Canada) (19) populations. Most of these studies found a relationship between the presence of $2 allele and hypertriglyceridemia (2)(3)(4)(5)(6)9,11,(13)(14)(15)(16)18,(20)(21)(22). An association of this allele with CAD was also reported (26)(27)(28).…”

“…An Sstl polymorphism resulting from a C->G base transversion in 3' untranslated region of APOC3 gene had been studied extensively in relation to hypertriglyceridemia . Here, the rare $2 allele apparently predisposes an individual to hypertriglyceride mia (2)(3)(4)(5)(6)9,11,(13)(14)(15)(16)18,(20)(21)(22). Asian Indians are reported to have high genetic predisposition to develop CAD.…”

A high-carbohydrate diet enhances the adverse effect of the S2 allele of APOC3 SstI polymorphism on the TG/HDL-C ratio only in young Chinese females

“…The SstI polymorphism is formed by a transversion from C to G and is located in the 3' untranslated region (3'UTR) of this gene (20). A number of studies have reported that the S2 carriers of the APOC3 SstI polymorphism had higher plasma levels of TG (21)(22)(23)(24)(25)(26), TC (27,28), LDL-C (27), and lower levels of HDL-C (27). The S2 allele was also associated with elevated plasma concentrations of apoCIII (29,30) and apoB (27,29,30), but not with lower apoAI levels (29).…”