Interaction between PAMAM 4.5 dendrimer, cadmium and bovine serum albumin: A study using equilibrium dialysis, isothermal titration calorimetry, zeta-potential and fluorescence

Preparation of self-assembled core–shell nano structure of conjugated generation 4.5 poly (amidoamine) dendrimer and monoclonal Anti-IL-6 antibody as bioimaging probe

“…When the molar ratio was further increased to 4:1, fractal growth of Table 1). The zeta potential of G4.5 dendrimers in deionized water was -56.5 ± 0.2 mV, which was in agreement with previous studies [23,31,32]. The antibody IL-6 is neutral in charge with zeta potential of -2.3 mV.…”

The interaction between PAMAM G3.5 dendrimer, Cd2+, dendrimer–Cd2+ complexes and human serum albumin

“…Only a few of these ions (6 out of 38) penetrate the dendrimer and react with the internal groups. The number of binding centers obtained for the G3.5 dendrimer (n = 38 ± 9) is about twice that for G4.5 (n = 23.8 ± 9.5) [19]. This difference could be the result of steric hindrance.…”

“…The low halfgenerations of PAMAM dendrimers are less toxic than the higher and full generations and can be used as potential chelators of toxic heavy metals in blood. The interaction between PAMAM 4.5 dendrimer, Cd 2+ , and serum albumin has been analyzed previously [19]. The present paper describes a study of the interaction between PAMAM G3.5, Cd 2+ , the "G3.5-Cd 2+ " complex and human serum albumin (HSA).…”

Nanomaterials in Stroke Treatment

“…[40][41][42] Dendrimer toxicity in biological system is generally characterized by hemolytic toxicity, cytotoxicity, hematologic toxicity, and interaction with proteins. [40][41][42][43][44][45] To minimize their toxicity, the critical nanoscale design parameters strategy has been used to synthesize biocompatible dendrimers or to mask peripheral charge of dendrimers by surface engineering. Several types of nontoxic dendrimers have been synthesized.…”