Interaction between risk factors for fetal growth retardation associated with abnormal umbilical artery Doppler studies

Spinillo, Arsenio; Bergante, Carola; Gardella, Bárbara; Mainini, Roberta; Montanari, Laura

doi:10.1080/j.0001-6349.2004.00295.x

Cited by 8 publications

(6 citation statements)

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“…Pre‐eclampsia play a significant causal role in the origin of fetal growth restriction associated with abnormal uteroplacental blood flow (23). In this study higher levels of apoptosis in umbilical arterial endothelium have been found in mild and severe pre‐eclampsia with intrauterine growth retardation.…”

Section: Discussionsupporting

confidence: 48%

Apoptotic and morphological features of the umbilical artery endothelium in mild and severe pre‐eclampsia

Yuluğ

Yenilmez

Ünsal

et al. 2006

Acta Obstet Gynecol Scand

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Section: Discussionsupporting

confidence: 48%

Apoptotic and morphological features of the umbilical artery endothelium in mild and severe pre‐eclampsia

Yuluğ

Yenilmez

Ünsal

et al. 2006

Acta Obstet Gynecol Scand

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“…Some studies have shown a strong correlation between low weekly maternal weight gain during pregnancy (Ͻ0.2 kg/wk) and fetal undergrowth (40). In our study, the weight gain during pregnancy was never below 0.2 kg/wk.…”

Section: Discussionmentioning

confidence: 76%

Elevated insulin sensitivity and β-cell function during pregnancy in mothers of growth-restricted newborns

Dalfrà

Pacini

Parretti

et al. 2011

American Journal of Physiology-Endocrinology and Metabolism

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The "Barker hypothesis" suggests that low birth weight might predict future risk of developing obesity, cardiovascular disease, and type 2 diabetes. Identification of the causes of fetal growth restriction (FGR) is critical for preventive and management strategies. Some studies indicate that maternal carbohydrate metabolism might be involved in FGR development. We aimed to evaluate, in a large number of normotensive pregnant women with normal glucose tolerance, the effect of insulin sensitivity and β-cell function on unexplained fetal growth. A total of 1,814 Caucasian pregnant women with normal prepregnancy body mass index were tested with a 75-g, 2-h glucose load (24-28 gestation wk). Insulin sensitivity was evaluated with fasting (QUICKI) and dynamic index (OGIS) and β-cell function with a modified insulinogenic index as ΔAUC(insulin)/ΔAUC(glucose) and disposition index. FGR was a birth weight below the 5th percentile for gestational age. FGR developed in 99 (5.5%) pregnant women that showed significantly higher QUICKI, OGIS, insulinogenic, and disposition index with respect to women with normal-weight babies (P < 0.0001). By using multiple regression analysis in the FRG group, QUICKI and OGIS appeared as significant independent variables (P < 0.0001 and P < 0.0366, respectively). We conclude that elevated insulin sensitivity seems to be one of the factors involved in determining unexplained fetal growth retardation; its assessment, even only in the fasting state, could be useful to guide any possible monitoring and therapeutic strategies to reduce fetal complications.

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“…This may be less pertinent in multiple pregnancies, which are a high‐risk group that carry a greater risk of maternal and fetal complications that may then lead to impaired uteroplacental blood flow. Pre‐eclampsia and maternal smoking have been found to be significantly correlated with the occurrence of absent/reversed end‐diastolic flow (AREDF) velocity in the UA. Pregnancies complicated by IUGR and/or hypertension have been found to have the highest risk of developing AREDF in the UA.…”

Section: Discussionmentioning

confidence: 99%

Umbilical and fetal middle cerebral artery Doppler reference ranges in a twin population followed longitudinally from 24 to 38 weeks' gestation

Mulcahy

McAuliffe

Breathnach

et al. 2014

Ultrasound in Obstet & Gyne

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Interaction between risk factors for fetal growth retardation associated with abnormal umbilical artery Doppler studies

Cited by 8 publications

References 0 publications

Apoptotic and morphological features of the umbilical artery endothelium in mild and severe pre‐eclampsia

Apoptotic and morphological features of the umbilical artery endothelium in mild and severe pre‐eclampsia

Elevated insulin sensitivity and β-cell function during pregnancy in mothers of growth-restricted newborns

Umbilical and fetal middle cerebral artery Doppler reference ranges in a twin population followed longitudinally from 24 to 38 weeks' gestation

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