Interaction between succinylcholine and ranitidine in rats

Abstract

The hypothesis that the histamine H 2 receptor blocker ranitidine potentiates neuromuscular paralysis during anaesthesia was tested in vivo in urethane anaesthetised and mechanically ventilated rats. Succinylcholine was administered as a bolus and constant-rate infusion to maintain 48.5% (• SEM) tibialis anterior muscle paralysis in 14 rats. Ranitidine 2.5,5,10, was (r e = 0,19, P< 0,05). Ces r$sultats d$montrent que la ranitidine altbre l'activit~ neuromusculaire de la succinylcholine chez les rats de la mdme fafon que la cim~tidine.Histamine H2 receptor antagonists are used to increase pH and decrease the volume of gastric contents before induction of anaesthesia to minimize aspiration pneumonitis, i Cimetidine, the prototypic H2 antagonist, has been commonly used for this purpose in the past but recently ranitidine has become popular. Normally, ranitidine, 150 mg, is administered po the night before surgery and one to two hours before induction of anaesthesia. Since ranitidine exhibits diverse cholinergic effects including an anti-cholinesterase and a neuromuscular blocking effect,2 there is potential for interaction between ranitidine and the neuromuscular blocking drugs administered to facilitate intubation and to maintain muscle relaxation during surgery.CAN J ANAESTH 1993 / 40:1 / pp 32-7

In vivo pharmacodynamic interaction between pipecuronium and certain H2 blockers

“…vivo. [16,17] Thus it is likely that the rightward shift of dose Discussion response curve of pipecuronium could be due to delay in onset of paralysis produced by famotidine. These results are Pipecuronium (50 mg/kg) produced complete blockade in contrast to those reported by Mishra et al [10] of the twitch responses of the sciatic nerve stimulated atracurium and gallamine whereas, we employed gastrocnemius preparation, which is in line with previous pipecuronium; therefore discrepancies could be attributed experimental [12] and clinical studies.…”

Effect of pantoprazole and its interactions with vecuronium on the neuromuscular junction

“…In contrast, ranitidine reverses the action of gallamine,[15] but produces an effect similar to cimetidine against succinylcholine. [16] Roxatidine delays the onset and decreases the total time for the compete block of vecuronium in rats. [17] Famotidine has been shown to have a negligible effect on neuromuscular transmission.…”