Interaction between Trichomonas vaginalis and other pathogenic micro-organisms of the human genital tract.

Street, D A; Wells, Claire M.; Taylor‐Robinson, David; Ackers, J. P.

doi:10.1136/sti.60.1.31

Cited by 23 publications

(19 citation statements)

References 11 publications

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“…Sperm cells in different stages of degradation were easily observed in both T. foetus and T. vaginalis vacuoles, showing that sperm cell digestion occurred as previously reported when bacteria (Street et al 1984;Benchimol and De Souza 1995) or yeast cells (Pereira-Neves and Benchimol 2007) were ingested.…”

Section: The Pseudocyst Formsupporting

confidence: 50%

Trichomonas adhere and phagocytose sperm cells: adhesion seems to be a prominent stage during interaction

et al. 2007

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Tritrichomonas foetus and Trichomonas vaginalis are extracellular parasites of the urogenital tract of cattle and humans, respectively. They cause infertility and abortion, but there is no documented information on the susceptibility of bovine sperm cells to this cattle parasite. The aim of this present work was to study the effects provoked by T. foetus and T. vaginalis when in interaction with bovine and human sperm cells. The bovine and human spermatozoa were obtained from uninfected bulls and men, respectively, and were exposed to living trichomonads over different periods of time. Light microscopy, video microscopy, scanning, and transmission electron microscopy first revealed a tropism, then a close proximity followed by a tight adhesion between these two different cells. A decrease in the spermatozoa motility was observed as well intense semen agglutination. The adhesion between trichomonads to the sperm cell occurred either by the flagella or sperm head. Motile parasites were observed during the next 12 h, whereas sperm cells in contact with the parasites rapidly became immotile. The parasites were able to maintain the sperm cells attached to their cell surface, followed by phagocytosis. This process began with a tight membrane-membrane adhesion and the incorporation of the sperm cell within an intracellular vacuole. Afterwards, the sperm cell was gradually digested in lysosomes. Many trichomonads were injured and/or died on making contact with the spermatozoa possibly due to necrosis. Results from this study demonstrated that both T. foetus and T. vaginalis interact with sperm cells provoking damage and death of these reproductive cells. Differences in the behavior of both trichomonads were evident, showing that T. vaginalis was much more virulent than T. foetus. The possible role of trichomonads in reproductive failure is discussed.

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Section: The Pseudocyst Formsupporting

confidence: 50%

Trichomonas adhere and phagocytose sperm cells: adhesion seems to be a prominent stage during interaction

et al. 2007

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“…In 1975, Ovcinnikov et al showed high phagocytic activity and endocytobiosis of bacteria, both Gram-negative and Gram-positive, by Trichomonas vaginalis. Street et al (1984) showed that Neisseria gonorrhoeae, Mycoplasma hominis and Chlamydia trachomatis attach to and are ingested by T. vaginalis. In the same way, Escherichia coli attaches to and is ingested by T. vaginalis and Tritrichomonas foetus, through a mechanism involving cell-to-cell recognition (Benchimol and de Souza 1995).…”

Section: Introductionmentioning

confidence: 99%

Growth kinetic study of Tetratrichomonas didelphidis isolated from opossum Lutreolina crassicaudata and interaction with a prokaryotic cell

Tasca

DeCarli

2001

Parasitol Res

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Tetratrichomonas didelphidis is a flagellate protozoan found in the intestine, cecum and colon of opossums, Didelphis marsupialis. This work reports the occurrence of T. didelphidis in another opossum species, Lutreolina crassicaudata. The strain was cultivated in monoxenic culture with Escherichia coli in Diamond (TYM) medium without maltose and with starch solution (trypticase-yeast extract-starch), pH 7.5 at 28 degrees C. The growth kinetic study of T. didelphidis showed a longer time of growth and a higher number of trophozoites when inoculated with E. coli than in axenic cultures, in aerobiosis as well as under anaerobic conditions. Scanning electron microscopy showed that the bacteria adhered throughout the protozoan body and probably evoked endocytic channels, strongly suggesting the existence of endocytosis of rods by T. didelphidis. Our preliminary results suggest that the in vitro culture of T. didelphidis depends on E. coli as a growth-promoting partner, and requires monoxenic cultivation.

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“…It is common knowledge that Trichomonas Vaginnlis, a parasitic protozoon of the human Urogenital tract, is able to ingest bacterial cells and Various particles in vitro and in vivo by a mechanism similar to that observed in other Phagocytic cells (1)(2)(3)(4)(5). As revealed by electron microscopy, phagocytosis in Tricf~omonas Vaginalis occurs preferentially in the posterior two-thirds of the cell body (4).…”

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confidence: 95%

In vitro phagocytic interaction betweenTrichomonas vaginalis isolates and bacteria

Juliano

Cappuccinelli

Mattana

1991

Eur. J. Clin. Microbiol. Infect. Dis.

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The phagocytic activity of 12 Trichomonas vaginalis isolates against both gram-positive bacteria (Staphylococcus aureus ATCC 25923, Lactobacillus spp.) and gram-negative bacteria (Enterobacter cloacae ATCC 13047, 5 strains of Escherichia coli, Pseudomonas aeruginosa ATCC 27853) was studied. Results showed that all the isolates were able to ingest Staphylococcus aureus to a variable degree, and almost all of them showed phagocytic activity against Pseudomonas aeruginosa. Furthermore, experiments with a restricted number of isolates of Trichomonas vaginalis showed that they phagocytized, often very effectively, human vaginal lactobacilli. Only in some cases was the addition of serum essential for bacteria ingestion. Phagocytic uptake of Escherichia coli and Enterobacter cloacae was not detectable under the experimental conditions used. It is concluded that phagocytosis may be involved in changes in vaginal biocenosis during the early stages of trichomoniasis.

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Interaction between Trichomonas vaginalis and other pathogenic micro-organisms of the human genital tract.

Cited by 23 publications

References 11 publications

Trichomonas adhere and phagocytose sperm cells: adhesion seems to be a prominent stage during interaction

Trichomonas adhere and phagocytose sperm cells: adhesion seems to be a prominent stage during interaction

Growth kinetic study of Tetratrichomonas didelphidis isolated from opossum Lutreolina crassicaudata and interaction with a prokaryotic cell

In vitro phagocytic interaction betweenTrichomonas vaginalis isolates and bacteria

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