Interaction Between Vascular Endothelial Growth Factor Gene Polymorphism and Smoking on Gastric Cancer Risk in Chinese Han Population

Abstract

Aim: In this study, we aimed to evaluate the associations of vascular endothelial growth factor (VEGF) gene single nucleotide polymorphisms (SNPs) and its interaction with current smoking with gastric cancer (GC) risk in the Chinese Han population.Methods: We used logistic regression model to test the association between VEGF gene polymorphism and the risk of GC. The association strength was evaluated by odds ratio (OR) and 95% confidence interval (CI) calculated using logistic regression. Generalized multifactor dimensionality reduction (GMDR) was used to analyze the effect of the interaction between VEGF gene and current smoking on GC risk.Results: Logistic regression analysis showed that the risk of GC was significantly higher in rs10434 -G allele carriers than that in AA genotype carriers (AG + GG and AA), and the adjusted OR (95% CI) = 1.64 (1.24–2.08). In addition, we found a significantly higher GC risk in subjects with rs833061-T allele than those with CC allele (CT + TT and CC), adjusted or (95% CI) = 1.43 (1.10–1.87). We also found a statistically significant two- locus model (p = 0.018), including rs10434 and current smoking, indicating a significant interaction between rs10434 and current smoking on the risk of GC. Hierarchical analysis found that current smokers with AG or GG genotype have the highest GC risk, compared to never- smokers with AA genotype, OR (95% CI) = 2.43 (1.64–3.28).Conclusion: We found that rs10434 -G and rs833061-T alleles, gene- environment interaction between rs10434, and current smoking were all related to increased GC risk.

Impact of interaction between interleukin-6 gene polymorphism and Helicobacter pylori infection on susceptibility to gastric cancer

“…All GC patients and normal controls were recruited from the Shanxi Province Cancer Hospital between June 2016 and July 2020. The criteria for diagnosis, inclusion and exclusion of GC patients and controls have been described in detail in previous studies (Wang et al , 2022). Consequently, a total of 1451 participants with an average age of 64.0 ± 10.1 years were selected, including 483 GC patients and 968 healthy controls.…”

Genetic Polymorphisms of Vascular Endothelial Growth Factor in Neonatal Pathologies: A Systematic Search and Narrative Synthesis of the Literature

“…Kim et al [ 6 ] reported that in the Korean population that VEGF gene 936 + C>T polymorphism could be an independent predictive marker in patients with gastric cancer. Studies evaluating the relationship between VEGF polymorphism and gastric and intestinal cancer have yielded inconclusive results [ 7 , 8 , 9 ]. Feng et al [ 10 ] showed, in a meta-analysis, that the VEGF +936C>T gene polymorphism is significantly associated with an increased risk of developing malignant digestive system tumors.…”