Interaction Effect in Bladder Cancer between N-Acetyltransferase 2 Genotype and Alcohol Drinking

Lu, Chih‐Ming; Chung, Meng-Chu; Huang, Chung-Hsiung; Ko, Ying‐Chin

doi:10.1159/000089175

Cited by 14 publications

(8 citation statements)

References 42 publications

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“…Upon closer examination, sixteen articles did not provide sufficient information to estimate a summary odds ratio and its 95% confidence intervals [17][18][19][20][21][22], or a summary odds ratio adjusted for at least age, sex and smoking [23][24][25][26][27][28][29][30][31][32]. The remaining 19 articles [33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] were chosen for detailed review.…”

Section: Resultsmentioning

confidence: 99%

A meta-analysis of alcohol intake and risk of bladder cancer

Mao

Lin

Zheng

et al. 2010

Cancer Causes Control

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Section: Resultsmentioning

confidence: 99%

A meta-analysis of alcohol intake and risk of bladder cancer

Mao

Lin

Zheng

et al. 2010

Cancer Causes Control

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“…However, the homozygotes of minor allele of NAT2 (rs1799930) SNP was associated with an increased risk of breast cancer among premenopausal (OR 2.70, 95% CI 1.20-6.07), although the number of the subjects were limited. Lu et al [23] showed an interaction effect in bladder cancer between NAT2 polymorphism and alcohol drinking. In addition, Rodrigo et al [24] reported that NAT2 activity may be a factor that determines the risk of developing alcoholic liver disease.…”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphisms in folate and alcohol metabolism and breast cancer risk: a case–control study in Thai women

Sangrajrang

Sato²,

Sanada³

et al. 2010

Breast Cancer Res Treat

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Dietary folate as well as polymorphic variants in one-carbon metabolism genes may modulate risk of breast cancer through aberrant DNA methylation and altered nucleotide synthesis and repair. Alcohol is well recognized as a risk factor for breast cancer, and interactions with one-carbon metabolism has also been suggested. The purpose of this study is to test the hypothesis that genetic polymorphisms in the folate and alcohol metabolic pathway are associated with breast cancer risk. Twenty-seven single nucleotide polymorphisms (SNPs) in the MTR, MTRR, MTHFR, TYMS, ADH1C, ALDH2, GSTP1, NAT1, NAT2, CYP2E1 DRD2, DRD3, and SLC6A4 were genotyped. Five hundred and seventy patients with histopathogically confirmed breast cancer and 497 controls were included in the present study. Association of genotypes with breast cancer risk was evaluated using multivariate logistic regression to estimate odds ratios (OR) and their 95% confidence intervals (95% CI). Increased risk was observed for homozygotes at the MTR SNPs (rs1770449 and rs1050993) with the OR = 2.21 (95% CI 1.18-4.16) and OR = 2.24 (95% CI 1.19-4.22), respectively. A stratified analysis by menopausal status indicated the association between the NAT2 SNP (rs1799930) and breast cancer was mainly evident in premenopausal women (OR 2.70, 95% CI 1.20-6.07), while the MTRR SNP (rs162049) was significant in postmenopausal women (OR 1.61, 95% CI 1.07-2.44). Furthermore, SNPs of the genes that contribute to alcohol behavior, DRD3 (rs167770), DRD2 (rs10891556), and SLC6A4 (rs140701), were also associated with an increased risk of breast cancer. No gene-gene or gene-environment interactions were observed in this study. Our results suggest that genetic polymorphisms in folate and alcohol metabolic pathway influence the risk of breast cancer in Thai population.

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“…[14][15][16][17][18][19][20][21][22] Furthermore, one study from Southern Taiwan revealed a lower frequency of the NAT2 fast acetylator genotype (54.3 percent, 76/103). 23 Thus, the analysis of NAT2 genetic polymorphisms in the cancer-free control population of this study may reflect the distribution of NAT2 genotypes in the Taiwanese population living in different geographic areas. Although, the frequency of NAT2 fast acetylator genotypes in the cancer-free control population was relatively lower than those of studies conducted in Northern Taiwan, the frequency of NAT2 fast acetylator genotype in this study was relatively comparable to most Taiwanese studies.…”

Section: Discussionmentioning

confidence: 88%

NAT2 Fast Acetylator Genotype is Associated with an Increased Risk of Colorectal Cancer in Taiwan

Huang

Chien

Wong

et al. 2007

Diseases of the Colon &Amp; Rectum

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In Taiwan, colorectal cancer has one of the highest rates of increased incidence in the past two decades. Heterocyclic amines from dietary cooked meats are metabolically activated by NAT2 (N-acetyltransferase 2), which are associated with colorectal cancer incidence. Thus, the NAT2 fast acetylator genotype may be associated with colorectal cancer risk. However, the association between the NAT2 genotype and colorectal cancer risk is not clearly understood. We conducted a study with 244 primary colorectal cancer cases and 299 cancer-free healthy control subjects to verify the association of NAT2 polymorphisms with the risk of Taiwanese colorectal cancer. Our data showed that subjects with the NAT2 W/W homozygous genotype had a 1.63-fold increased risk of colorectal cancer compared with those with the Mx/Mx slow acetylator genotype (95 percent confidence interval, 1.03-2.58); however, no risk was found in the W/Mx heterozygous and Mx/W+W/W fast acetylator genotypes. Being stratified by gender factors, the colorectal cancer risk in females with homozygous W/W or Mx/W+W/W fast acetylators increased 2.47-fold and 2.13-fold compared with those with the Mx/Mx slow acetylator genotype (95 percent confidence interval, 1.27-4.82 for W/W genotype; 95 percent confidence interval, 1.17-3.89 for Mx/W+W/W genotype); however, the risk of the NAT2 genotype and colorectal cancer was not observed in males. Collectively, patients with the NAT2 fast acetylator genotype were more prone to colorectal cancer and reflected the possibility that exposure to heterocyclic amines may contribute to colorectal cancer development in Taiwan, especially in Taiwanese females.

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Interaction Effect in Bladder Cancer between N-Acetyltransferase 2 Genotype and Alcohol Drinking

Cited by 14 publications

References 42 publications

A meta-analysis of alcohol intake and risk of bladder cancer

A meta-analysis of alcohol intake and risk of bladder cancer

Genetic polymorphisms in folate and alcohol metabolism and breast cancer risk: a case–control study in Thai women

NAT2 Fast Acetylator Genotype is Associated with an Increased Risk of Colorectal Cancer in Taiwan

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