Interaction effect of crocin and citalopram on memory and locomotor activity in rats: an insight into BDNF and synaptophysin levels in the hippocampus

Nasseri, Samineh; Hajrasouliha, Shadi; Vaseghi, Salar; Ghorbani Yekta, Batool

doi:10.1007/s00210-024-03069-9

Cited by 5 publications

(1 citation statement)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Administering neonatal prebiotics (BGOs) to mice at 22 days of age resulted in elevated levels of synaptophysin and brain-derived neurotrophic factor (BDNF) in the hippocampus, as compared to other prebiotics [21,22]. Both BDNF and synaptic vesicle protein synaptophysin act as signaling molecules that facilitate the formation of synapses between neurons [23]. They also play a crucial role in the survival, growth, maturation, and maintenance of different populations of brain cells.…”

Section: Early Brain Development: An Additional Potential For the Tra...mentioning

confidence: 99%

The Potential Impact of the Gut Microbiota on Neonatal Brain Development and Adverse Health Outcomes

Tzitiridou-Chatzopoulou,

Kountouras,

Zournatzidou

2024

Children

View full text Add to dashboard Cite

Over the past decade, microbiome research has significantly expanded in both scope and volume, leading to the development of new models and treatments targeting the gut–brain axis to mitigate the effects of various disorders. Related research suggests that interventions during the critical period from birth to three years old may yield the greatest benefits. Investigating the substantial link between the gut and brain during this crucial developmental phase raises fundamental issues about the role of microorganisms in human health and brain development. This underscores the importance of focusing on the prevention rather than the treatment of neurodevelopmental and neuropsychiatric disorders. The present review examines the gut microbiota from birth to age 3, with a particular focus on its potential relationship with neurodevelopment. This review emphasizes the immunological mechanisms underlying this relationship. Additionally, the study investigates the impact of the microbiome on cognitive development and neurobehavioral issues such as anxiety and autism. Importantly, it highlights the need to integrate mechanistic studies of animal models with epidemiological research across diverse cultures to better understand the role of a healthy microbiome in early life and the implications of dysbiosis. Furthermore, this review summarizes factors contributing to the transmission of gut microbiome-targeted therapies and their effects on neurodevelopment. Recent studies on environmental toxins known to impact neurodevelopment are also reviewed, exploring whether the microbiota may mitigate or modulate these effects.

show abstract

Section: Early Brain Development: An Additional Potential For the Tra...mentioning

confidence: 99%