Interaction Effect of Phase Angle and Age on Femoral Neck Bone Mineral Density in Patients with Non-Dialysis Chronic Kidney Disease Stage 5

Han, Byoung Geun; Pak, Daewoo; Lee, Joon Young; Kim, Jae‐Seok; Yang, Jae-Won; Kim, Seongyup

doi:10.3390/nu15071680

Cited by 3 publications

(2 citation statements)

References 44 publications

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“…Although, no previous studies were located that investigated the association between PhA and BMD in children and adolescents [ 22 ]. In patients with chronic kidney disease, PhA was directly associated with femoral neck BMD, even after considering the effects of age, alkaline phosphatase, intact parathyroid hormone, and LSTM [ 37 ]. In older adults, PhA was directly associated with total BMD, femur BMD, and neck BMD, even after adjustment for covariates that included sociodemographic variables (e.g., age) and personal history of fractures [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Phase Angle and Body Composition of Children and Adolescents Diagnosed with HIV Infection

Martins,

de Lima,

Silva

et al. 2023

Children

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The aim of the study was to investigate how phase angle (PhA) is associated with subtotal and lumbar spine bone mineral density [BMD], lean soft tissue mass [LSTM], total body fat mass, android and gynoid in children and adolescents with HIV according to sex. A cross-sectional study was conducted in Florianópolis, Brazil, involving 64 children and adolescents vertically transmitted with HIV. Resistance and reactance values were obtained using bioelectrical impedance analysis, and PhA was subsequently calculated. Dual emission X-ray absorptiometry was used to assess body composition. Antiretroviral medication, physical activity (accelerometers) and skeletal maturation (wrist-carpal radiography) were used in the adjusted model. In males, PhA was directly associated with subtotal BMD (βadj: 0.65; R²: 0.38, p < 0.01) and lumbar spine BMD (βadj: 0.53; R²: 0.22, p = 0.01), directly associated with LSTM (βadj: 0.76; R²: 0.46, p < 0.01), and inversely associated with gynoid fat (βadj: −0.47; R²: 0.2, p = 0.01), in adjusted models. In females, PhA was directly associated with subtotal BMD (βadj: 0.46; R²: 0.17, p < 0.01) and lumbar spine BMD (βadj: 0.48; R²: 0.19, p < 0.01). It is concluded that PhA was directly associated with subtotal and regional BMD, LSTM, and inversely with gynoid fat in boys with HIV. In girls, PA was directly associated only with subtotal and regional BMD.

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Section: Discussionmentioning

confidence: 99%

Association between Phase Angle and Body Composition of Children and Adolescents Diagnosed with HIV Infection

Martins,

de Lima,

Silva

et al. 2023

Children

View full text Add to dashboard Cite

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“…Local bone destruction (called fibrous osteoarthritis) can be observed in some cases of CKD using computed tomography (CT) or X-ray, while osteoporosis is more frequently seen (7). CT attenuation decrease of bone can be seen in most patients with CKD5 (8).…”

Section: Introductionmentioning

confidence: 99%

Chest CT radiomics is feasible in evaluating bone changes in chronic kidney diseases

Wu,

Yang,

Liu

2024

Acta Radiol

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Background Non-invasive imaging methods are still lacking for evaluating bone changes in chronic kidney diseases (CKD). Purpose To investigate the feasibility of chest CT radiomics in evaluating bone changes caused by CKD. Material and Methods In total, 75 patients with stage 1 CKD (CKD1) and 75 with stage 5 CKD (CKD5) were assessed using the chest CT radiomics method. Radiomics features of bone were obtained using 3D Slicer software and were then compared between CKD1 and CKD5 cases. The methods of maximum correlation minimum redundancy (mRMR) and least absolute shrinkage and selection operator (LASSO) were used to establish a prediction model to determine CKD. The receiver operating characteristic (ROC) curve was used to determine the performance of the model. Results Cases of CKD1 and CKD5 differed in 40 radiomics features ( P <0.05). Using the mRMR and LASSO methods, five features were finally selected to establish a predication model. The area under the receiver operating characteristic curve of the model in the determination of CKD1 and CKD5 was 0.903 and 0.854, respectively, for the training and validation cohorts. Conclusion Chest CT radiomics is feasible in evaluating bone changes caused by CKD.

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Phase angle is a useful predicting indicator for protein-energy wasting and cardiovascular risk among maintenance hemodialysis patients

Wang,

Chen,

Zhang

et al. 2024

Sci Rep

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Protein-energy wasting (PEW) is a major contributor to the high mortality among maintenance hemodialysis (MHD) patients. Cardiovascular disease (CVD) is the leading cause of death in dialysis patients, and PEW can significantly increase cardiovascular mortality in MHD patients. Previous studies have confirmed that PA may be a good objective indicator for determining the nutritional status and prognosis of MHD patients. Our study aimed to determine the predictive value of phase angle (PA) as detected by bioelectrical impedance analysis (BIA) on PEW and cardiovascular (CV) risk among MHD patients. Our retrospective observational study involved 161 adult patients with HD. The Cardiovascular risk score is a risk model based on the Japan Dialysis Outcome and Practice Patterns Study (J-DOPPS). We established LASSO logistic regression analysis model to identify key parameters related to body composition that can predict PEW in MHD patients. The area under the curve (AUC) values for PA, appendicular skeletal muscle mass index (ASMI), body cell mass (BCM), and mid-arm circumference (MAC) in predicting PEW in male MHD patients were relatively large, with 0.708, 0.674, 0.663, and 0.735, respectively.The predicted PEW values of these parameters were slightly lower in female patients than in men. We incorporated PA, ASMI, BCM, and MAC into a model that predicted the incidence of PEW in maintenance hemodialysis patients using LASSO technology. We discovered that the model predicted a greater AUC of PEW occurrence than any single factor, 0.877 for men and 0.76 for women. The results of the univariate logistic regression analysis showed that the low PA tertile array group had a greater incidence of PEW than the high PA group (P < 0.001). Additionally, we also found that lower PA was associated with higher CV risk scores. The PA detected by bioelectrical impedance analysis could predict the risk of PEW and cardiovascular events among patients with MHD. When used in conjunction, PA, ASMI, BCM, and MAC have a high diagnostic efficacy for PEW in patients on maintenance hemodialysis.

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Interaction Effect of Phase Angle and Age on Femoral Neck Bone Mineral Density in Patients with Non-Dialysis Chronic Kidney Disease Stage 5

Cited by 3 publications

References 44 publications

Association between Phase Angle and Body Composition of Children and Adolescents Diagnosed with HIV Infection

Association between Phase Angle and Body Composition of Children and Adolescents Diagnosed with HIV Infection

Chest CT radiomics is feasible in evaluating bone changes in chronic kidney diseases

Phase angle is a useful predicting indicator for protein-energy wasting and cardiovascular risk among maintenance hemodialysis patients

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