Interaction of Basic Amino Acids, Polypeptides and Proteins with Heparin

In vivo bioactivity of rhBMP-2 delivered with novel polyelectrolyte complexation shells assembled on an alginate microbead core template

“…The cationic polyamino acids (PLO, PLA) possess higher charge densities in comparison to the polysaccharide, DEAD-D [48]. This higher charge density drives a stronger electrostatic interaction with heparin and would more effectively neutralize the surface anionic charges of heparin [49][50][51][52]. Therefore, heparin condensation is expected to be more efficient with the cationic polyamino acids compared to the polysaccharide (Fig.…”