Interaction of G-protein  3 Subunit and Nitric Oxide Synthase Gene Polymorphisms on Carotid Artery Intima-media Thickness in Young Adults: The Bogalusa Heart Study

Bhuiyan, Azad R.; Chen, Wei; Srinivasan, Sathanur R.; Rice, Janet C.; Mock, Nancy B.; Tang, Rong; Bond, M. Gene; Boerwinkle, Eric; Berenson, Gerald S.

doi:10.1038/ajh.2008.188

Cited by 3 publications

(2 citation statements)

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“…43 In summary, the 825T homozygosis of the GNB3 gene is significantly and independently associated with increased risk of incident CE in general population. Carrying the TT genotype exposes to additional risk of CE independent of blood pressure values and other established risk factors of stroke.…”

Section: Discussionmentioning

confidence: 99%

The C825T GNB3 polymorphism, independent of blood pressure, predicts cerebrovascular risk at a population level

Casíglia

Tikhonoff

Boschetti

et al. 2012

American Journal of Hypertension

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Section: Discussionmentioning

confidence: 99%

The C825T GNB3 polymorphism, independent of blood pressure, predicts cerebrovascular risk at a population level

Casíglia

Tikhonoff

Boschetti

et al. 2012

American Journal of Hypertension

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“…Reports showing an association between the G894T polymorphism, vascular complications and hypertension in humans are not consistent [ 10 – 17 , 36 ]. The meta-analysis of Niu and Qi indicated that the T894 allele may be associated with an increased risk of hypertension.…”

Section: Discussionmentioning

confidence: 99%

Associations of the eNOS G894T gene polymorphism with target organ damage in children with newly diagnosed primary hypertension

et al. 2015

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BackgroundThe endothelial nitric oxide synthase (eNOS) G894T gene polymorphism is associated with the risk of primary hypertension (PH) and vascular complications in adults with PH.MethodsWe explored the associations of the G894T polymorphism with 24-h ambulatory blood pressure, left ventricular mass (LVM), carotid intima media thickness (cIMT), urinary albumin excretion, oxidative stress and inflammatory parameters in 126 children with newly diagnosed PH and in 83 healthy children.ResultsAmong the 126 children with PH 92 (73 %) had ambulatory hypertension and 34 (27 %) had severe ambulatory hypertension. Left ventricular hypertrophy (LVH) was detected in 39 (31 %) patients, cIMT of >2 standard deviation scores in 21 (16.6 %) patients, albuminuria of >30 mg/24 h in 18 (14.3 %) patients and metabolic syndrome (MS) in 22 (17.5 %) patients. The frequency of the T allele was 52.4 % in the PH group and 54.2 % in the control group (not significant), and in both groups the frequency of the T allele was consistent with the Hardy–Weinberg equilibrium. Compared with G allele carriers, hypertensive T allele carriers had increased cIMT (p < 0.05) and more severe albuminuria (not significant, p = 0.1); there was no difference between the groups in hypertension severity and LVM. T and G allele distribution did not differ between patients with and without metabolic syndrome. No significant correlations between the assessed parameters and the eNOS G894T gene polymorphism were found in the controls, although T allele carriers tended to have an increased cIMT (p = 0.09).ConclusionThe eNOS T allele is not more prevalent among hypertensive children than among healthy ones, but it is associated with early vascular damage in children with PH, independent of metabolic abnormalities. No associations between the eNOS G894T polymorphism and metabolic abnormalities were found.

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Endothelial nitric oxide synthase - regulation and clinical relevance

Sinzinger

Berent²

2014

Thrombosis Research

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Interaction of G-protein 3 Subunit and Nitric Oxide Synthase Gene Polymorphisms on Carotid Artery Intima-media Thickness in Young Adults: The Bogalusa Heart Study

Abstract: These results indicate that the genetic variations of the eNOS gene in combination with the GNB3 gene jointly influence carotid artery wall thickening process in young adults, especially in blacks.

Cited by 3 publications

References 37 publications

The C825T GNB3 polymorphism, independent of blood pressure, predicts cerebrovascular risk at a population level

The C825T GNB3 polymorphism, independent of blood pressure, predicts cerebrovascular risk at a population level

Associations of the eNOS G894T gene polymorphism with target organ damage in children with newly diagnosed primary hypertension

Endothelial nitric oxide synthase - regulation and clinical relevance

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