Interaction of Long Noncoding RNAs and Notch Signaling: Implications for Tissue Homeostasis Loss

Salviano-Silva, Amanda; Berti, Fernanda Costa Brandão; Lobo‐Alves, Sara Cristina; Araujo-Souza, Patricia Savio de; Boldt, Angelica Beate Winter; Malheiros, Danielle

doi:10.1007/978-3-030-36422-9_8

Cited by 2 publications

(1 citation statement)

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“…The dynamic fine-tuning of NOTCH signalling is achieved by post-transcriptional and post-translational regulation. The first includes the control of RNA stability by RNA-binding proteins and microRNAs [ 50 , 51 ]. For example, NOTCH1 mRNA stability is modulated by the methylation of adenine (m 6 A) residues by N 6 -methyladenosine methyltransferases such as METTL3 and METTL14 [ 52 , 53 ].…”

Section: Introductionmentioning

confidence: 99%

Regulation of Notch1 Signalling by Long Non-Coding RNAs in Cancers and Other Health Disorders

Kałafut

Czerwonka

Dudziak

et al. 2023

IJMS

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Notch1 signalling plays a multifaceted role in tissue development and homeostasis. Currently, due to the pivotal role of Notch1 signalling, the relationship between NOTCH1 expression and the development of health disorders is being intensively studied. Nevertheless, Notch1 signalling is not only controlled at the transcriptional level but also by a variety of post-translational events. First is the ligand-dependent mechanical activation of NOTCH receptors and then the intracellular crosstalk with other signalling molecules—among those are long non-coding RNAs (lncRNAs). In this review, we provide a detailed overview of the specific role of lncRNAs in the modulation of Notch1 signalling, from expression to activity, and their connection with the development of health disorders, especially cancers.

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