Interaction of pDNA with reverse phase chitosome

Mertins, Omar; Lobo, Sonja Ellen; Mathews, Patrick D.; Han, Sang Won

doi:10.1016/j.colsurfa.2018.02.005

Cited by 12 publications

(9 citation statements)

References 29 publications

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“…The custom chemical synthesis of charged lipids, strategically designed [65], represents a plethora of means for the purposeful production of cubosomes for many specific drug delivery applications besides the gene delivery studies [90][91][92]. Whereas cubosomes were previously sterically stabilized by PEGylated lipids and non-ionic copolymer shells [93,94], more recent research directions tend to combine the advantages of both lipid and polymer derivatives [95][96][97][98][99][100][101][102]. Furthermore, the production of composite cubosomes and cubic phases by associating lipids with macromolecules of pH-dependent structure, including large proteins, polypeptides, polymers, polysaccharides and peptide conjugates [21,97,103,104], can provide a wider range of novel delivery systems [105][106][107][108][109][110][111][112].…”

Section: Perspectives Of Ph-sensitive Cubosomesmentioning

confidence: 99%

Advances in the Design of pH-Sensitive Cubosome Liquid Crystalline Nanocarriers for Drug Delivery Applications

2020

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Nanostructure bicontinuous cubic phase self-assembled materials are receiving expanding applications as biocompatible delivery systems in various therapeutic fields. The functionalization of cubosome, spongosome, hexosome and liposome nanocarriers by pH-sensitive lipids and/or pH-sensitive polymer shells offers new opportunities for oral and topical drug delivery towards a new generation of cancer therapies. The electrochemical behavior of drug compounds may favor pH-triggered drug release as well. Here, we highlight recent investigations, which explore the phase behavior of mixed nonlamellar lipid/fatty acid or phospholipid systems for the design of pH-responsive and mucoadhesive drug delivery systems with sustained-release properties. X-ray diffraction and small-angle X-ray scattering (SAXS) techniques are widely used in the development of innovative delivery assemblies through detailed structural analyses of multiple amphiphilic compositions from the lipid/co-lipid/water phase diagrams. pH-responsive nanoscale materials and nanoparticles are required for challenging therapeutic applications such as oral delivery of therapeutic proteins and peptides as well as of poorly water-soluble substances. Perspective nanomedicine developments with smart cubosome nanocarriers may exploit compositions elaborated to overcome the intestinal obstacles, dual-drug loaded pH-sensitive liquid crystalline architectures aiming at enhanced therapeutic efficacy, as well as composite (lipid/polyelectrolyte) types of mucoadhesive controlled release colloidal cubosomal formulations for the improvement of the drugs’ bioavailability.

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Section: Perspectives Of Ph-sensitive Cubosomesmentioning

confidence: 99%

Advances in the Design of pH-Sensitive Cubosome Liquid Crystalline Nanocarriers for Drug Delivery Applications

2020

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“…Motivasi Ekonomi merupakan dorongan yang timbul dari dalam diri seseorang untuk meningkatkan kemampuan pribadinya dalam rangka untuk mencapai penghargaan finansial yang diinginkannya (Mahmud, 2008). Motivasi untuk men-ADIA ADI PRABAWA dapatkan pekerjaan dan cita-cita untuk meraih prestasi menjadi faktor pendorong utama minat mahasiswa mengikuti ujian CPA.…”

Section: Motivasi Ekonomi Berpengaruh Terhadap Minat Mahasiswa Akuntaunclassified

“…Kondisi ini dapat dipahami, mengingat adanya anggapan bahwa akuntan menawarkan penghasilan yang lebih tinggi dari pada pekerjaan dalam bidang yang lain. (Mahmud, 2008).…”

Section: Motivasi Ekonomi Berpengaruh Terhadap Minat Mahasiswa Akuntaunclassified

“…Elemen kualitas dan kompetensi merupakan hal yang sangat diperhatikan dalam profesi akuntan publik. Bahkan, di dalam standar umum auditing yang pertama menyebutkan secara jelas menyatakan bahwa audit harus dilaksanakan oleh seseorang lebih baik yang memiliki keahlian dan pelatihan teknis yang cukup sebagai auditor (Mahmud, 2008).…”

Section: Motivasi Kualitas Berpengaruh Terhadap Minat Mahasiswa Akuntunclassified

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Faktor-Faktor Yang Mempengaruhi Mahasiswa Akuntansi Fe Ust Mengikuti Ujian Sertifikasi Akuntan Publik (Usap)

Prabowo¹

2020

jkb

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Students who want to work as public accountants are required to first take thePublic Accountants Certification Exam which is held by the Indonesian Instituteof Certified Public Accountants, but students who take the public accountantcertification exam are still minimal. The purpose of this study is to determine theeffect of economic motivation, personality, barriers, social motivation and qualitymotivation on accounting students’ interest in taking the Public AccountantCertification Exam.The research respondents were all students of semester VIand above Accounting Study Program Department of AccountingSarjanawiyataTamansiswa University. The instrument testing was carried out usingvalidity and reliability tests. To determine the accuracy of the model, classicalassumption testing is carried out followed by multiple regression analysis bothpartially and simultaneously. The results of this study indicate that the variablesof economic motivation, personality, exam barriers, social motivation and qualitymotivation simultaneously influence the interest of accounting students takingthe Public Accountant Certification Exam by explaining the variation expressedin the coefficient of determination, showing that 66.6% of the variation in interestdetermined by social motivation and personality, while 33.4% is determined byother variables not examined in this study but partially personality and socialmotivation have a significant influence on the interests of accounting studentstaking the Public Accountant Certification Exam, while economic motivationvariables, test barriers, and quality motivation does not have a significant influenceon the interests of accounting students taking the Public Accountant CertificationExam.

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“…Mucoadhesion favors the absorption of the active substances, transported by the liposome carriers, and leads to increased drug bioavailability [40][41][42]. Liposomes associated with chitosan have been exploited in the development of nanomaterials for encapsulation of drugs, plasmid DNA and vaccines [43][44][45][46]. It has been shown that the coating of liposomes by chitosan leads to significant mucoadhesion of the nanostructures as well as to increased bioavailability of the encapsulated active agents [47][48][49].…”

Section: Introductionmentioning

confidence: 99%

Cubosomal lipid nanoassemblies with pH-sensitive shells created by biopolymer complexes: A synchrotron SAXS study

Mathews

Mertins

Angelov

et al. 2022

Journal of Colloid and Interface Science

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Interaction of pDNA with reverse phase chitosome

Cited by 12 publications

References 29 publications

Advances in the Design of pH-Sensitive Cubosome Liquid Crystalline Nanocarriers for Drug Delivery Applications

Advances in the Design of pH-Sensitive Cubosome Liquid Crystalline Nanocarriers for Drug Delivery Applications

Faktor-Faktor Yang Mempengaruhi Mahasiswa Akuntansi Fe Ust Mengikuti Ujian Sertifikasi Akuntan Publik (Usap)

Cubosomal lipid nanoassemblies with pH-sensitive shells created by biopolymer complexes: A synchrotron SAXS study

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