Interaction of Propranolol with Garlic in Isoproterenol Induced Myocardial Infarction in Rat

Asdaq, Syed Mohammed Basheeruddin; Inamdar, Mohammed Naseeruddin; Asad, Mohammad Reza; Nanjundan, Prem Kumar

doi:10.3923/jpt.2008.414.424

Cited by 20 publications

(22 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study prophylactic treatment with HCTZ alone showed protection against myocardial damage but it is not substantial to prove its protective behavior. 17,18 Green Tea belongs to family Camellia sinensis, having rich source of poly phenols and reported its potency against cardiovascular disease risk factors. Green Tea is responsible to reduce in body weight by interfering within the sympathoadrenal system and fatty acid synthesis, decrease cholesterol absorption and plasma levels, have strong free radical-scaven ging activity inhibiting LDL oxidation, reduce the adhesion molecule expression and have antithrombotic activities by inhibiting platelet aggregation and decrease systolic and diastolic blood pressures.…”

Section: Discussionmentioning

confidence: 99%

Pharmacodynamic Interaction of Green Tea Extract With Hydrochlorothiazide Against Isoproterenol Induced Myocardial Damage in Rats

Chakraborty¹,

Kamath²

2014

Int. Res. J. Pharm.

View full text Add to dashboard Cite

To evaluate the pharmacodynamic interaction of green tea extract with hydrochlorothiazide against isoproterenol induced myocardial infarction wistar albino rat of either sex were prophylactically treated with hydrochlorothiazide (10 mg/kg for 7 days), low and high dose of green tea extract (100 and 500 mg/kg for 3 weeks) and their combination by oral route. To induce the toxicity apart from normal control all other group subjected to isoproterenol (150 mg/kg, s.c) for two consecutive days. The effect of prophylactic treatment was analyzed by estimation of electrocardiographic changes, serum biomarker levels, antioxidant level in tissue and histopathological report. Green tea in both high and low dose and their combination groups with hydrochlorothiazide significantly reduced the serum biomarker levels, increased antioxidant levels in tissue, restored the electrocardiographic changes compared to isoproterenol only treated group. The combination group showed substantial amount of restoration of all the parameters compared to hydrochlorothiazide alone treated group. To conclude the combination of green tea extract with hydrochlorothiazide reduced the side effect and found to be effective against myocardial stress.

show abstract

Section: Discussionmentioning

confidence: 99%

Pharmacodynamic Interaction of Green Tea Extract With Hydrochlorothiazide Against Isoproterenol Induced Myocardial Damage in Rats

Chakraborty¹,

Kamath²

2014

Int. Res. J. Pharm.

View full text Add to dashboard Cite

show abstract

“…Alike Upaganlawar et al [28] , proposed that the increase of the heart weight upon administration of ISO might be due the increased water content and oedematous intramuscular spaces. Asdaq et al [29] added that ISOinduced alterations of the membrane permeability might have brought loss of myocardial membrane function which could be another cause of the interstitial edema in experimental rats.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, vitamin E was able to stabilize heart phospholipids by preventing the change in fatty acid composition and the peroxidative deterioration [47] . Nevertheless, vitamin E not only reduces lipid peroxidation but also preserves glutathione levels in high amounts in these tissues by either encouraging the synthesis of endogenous antioxidants or inhibiting the generation of oxidants such as ROS through supporting the endogenous antioxidant system [29,48] .…”

Section: Discussionmentioning

confidence: 99%

Role of Different Doses of Vitamin E in Protection Against Isoproterenol-Induced Myocardial Damage in Adult Male Albino Rat: A Light and Electron Microscopic Study

Aboraya

Ibrahim

Qureshi

2017

Egyptian Journal of Histology

View full text Add to dashboard Cite

Introduction: Cardiovascular diseases are one of the most common diseases in the world. It is essential to find an efficient natural protective agent against the myocardial damage. Aim: To determine the protective role of different doses of vitamin E against isoproterenol-induced myocardial damage. Material and Methods: Fifty adult male albino rats were divided into four main groups: Control group (I), vitamin E-treated group (II) equally divided into 2 subgroups; subgroup (IIa) received Vit E (50mg/kg) and subgroup (IIb) received Vit E (100mg/kg) for one month, isoproterenol-treated group (III) received 3ml normal saline orally for one month and isoproterenol (150mg/kg) intraperitoneally (IP) in the last two days of that month. Vitamin E and isoproterenol-treated group (IV) equally divided into two subgroups; Subgroup (IVa) received vitamin E (50mg/kg) orally for one month and isoproterenol (150mg/kg) IP in the last two days of that month and subgroup (IVb) received vitamin E (100mg/kg) orally for one month and isoproterenol (150mg/kg) IP in the last two days of that month. Heart specimens were processed for light and electron microscopic studies. Results: Rats injected by isoproterenol developed structural changes in the myocardium in the form of fragmentation of the myofibrils, vacuolated destroyed mitochondria, dilated SER, intracellular and extracellular edema and interstitial mononuclear cellular infiltration. Animals pretreated with vitamin E at a dose of 50mg/kg before injection of isoproterenol revealed minimal protection as they showed myocardial damage similar to isoproterenol-treated group. While animals pretreated with vitamin E at a dose of 100 mg/kg before injection of isoproterenol showed minimal microscopic alterations of the myocardium with preservation of the normal structure of the cardiac myocytes. Conclusion: Vitamin E at a high dose (100mg/kg) has a protective role on myocardium against isoproterenol-induced myocardial damage.

show abstract

“…Preparation of heart for histological examination: 16 Heart tissue was taken in 10% formalin for overnight. Dehydration was carried out by keeping the tissue in ethanol (ranging from 70-100%).…”

Section: Methodsmentioning

confidence: 99%

Protective Effect of Peanut (Arachis hypogaea L.) and Its Combination with Propranolol in Cardiotoxic Rats

Naz

Jahan

Sultana³

2015

J Bangladesh Soc Physiol

View full text Add to dashboard Cite

Background: Cardiotoxicity (CT) can be developed due to prolonged use of higher doses of some drugs, exposure to some chemicals, toxins or infectious agents and also by some disease conditions. Natural plant foods such as peanut (Arachis hypogaea L.) may have free radical scavenging activity, thereby can be used for the prevention and management of heart disease. Objective: To observe the protective effect of peanut (Arachis hypogaea L.) and its combined action with propranolol on histological changes in isoproterenol induced cardiotoxic rats. Method: This experimental study was carried out in the Department of Physiology, Sir Salimullah Medical College, Dhaka in 2012. For this purpose, 20 Wistar albino rats, age 85-100 days, weighing 120 to 150g (initial body weight) were included in the peanut treated group. They were sub-divided into CT-ISO-P (Cardiotoxic group with isoproterenol after peanut treatment) and CT-ISO-C (Cardiotoxic group with isoproterenol after combined treatment of peanut and propranolol). Age and weight matched 30 Wistar albino rats without any peanut supplementation were taken and sub-divided into three sub-groups, BC (Baseline control), CT-ISO (Cardiotoxic group with isoproterenol) and CT-ISO-PRO (Cardiotoxic group with isoproterenol after propranolol treatment). Each sub-group consisted of 10 rats. After taking final body weight all the rats were sacrificed on 22 nd day. The heart was removed and preserved in 10% formalin for histological processing. To find out the histopathological changes of heart tissue, histological slides were prepared and were observed under microscope in the Department of Pathology, SSMC. Histological findings were categorized by scoring as mild, moderate and severe histological changes. The statistical analysis was done by one way ANOVA and Bonferroni test as applicable. Result: In this study, percent change from initial body weight to final body weight was significantly (p<0.01) lower both in CT-ISO-P and CT-ISO-C as compared to that of BC. Again, histological score was significantly (p<0.01) higher in CT-ISO in comparison to that of BC. Moreover, these scores were significantly lower in CT-ISO-PRO (p<0.01), CT-ISO-P (p<0.05) and CT-ISO-C (p<0.05) in comparison to that of CT-ISO. Similarly, this score was significantly (p<0.01) lower in CT-ISO-C when compared to that of CT-ISO-P. Conclusion: The present study revealed that peanut can preserve almost normal histological architecture of heart tissue in isoproterenol induced cardiotoxic rats. However, the combined therapy of peanut with propranolol showed synergistic effect on preventing histological changes in heart tissue.

show abstract

Interaction of Propranolol with Garlic in Isoproterenol Induced Myocardial Infarction in Rat

Cited by 20 publications

References 0 publications

Pharmacodynamic Interaction of Green Tea Extract With Hydrochlorothiazide Against Isoproterenol Induced Myocardial Damage in Rats

Pharmacodynamic Interaction of Green Tea Extract With Hydrochlorothiazide Against Isoproterenol Induced Myocardial Damage in Rats

Role of Different Doses of Vitamin E in Protection Against Isoproterenol-Induced Myocardial Damage in Adult Male Albino Rat: A Light and Electron Microscopic Study

Protective Effect of Peanut (Arachis hypogaea L.) and Its Combination with Propranolol in Cardiotoxic Rats

Contact Info

Product

Resources

About