Abstract:Homogenous bacteriorhodopsin-DPPC proteoliposomes were characterized and used as a target for the general anesthetic Enflurane. Dose-response curves for the protein and the lipids, in the very same sample, at high (2800) and low (360) lipid: bacteriorhodopsin molar ratios, were compared simultaneously. Above the main phase transition temperature of DPPC, there is no difference between the protein and lipid sensitivities toward the anesthetic. Below the main phase transition temperature of DPPC, the bacteriorho… Show more
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