Interactions Between Adenosine Receptors and Cordycepin (3'- Deoxyadenosine) from Cordyceps Militaris: Possible Pharmacological Mechanisms for Protection of the Brain and the Amelioration of Covid-19 Pneumonia

Du, Jing; Kan, Weijing; Bao, Hongkun; Jia, Yunyi; Yang, Jian Wei; Jia, Huang

doi:10.26502/jbb.2642-91280035

Cited by 5 publications

(3 citation statements)

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“…Limited literature showed that A2B and A3 receptors play a role in regulating inflammation and excitotoxicity in cerebral ischemia due to their low level in the brain (Ham and Rees, 2008;Pedata et al, 2016). Cordycepin may inhibit the production of proinflammatory cytokines through the A3 receptor to produce anti-inflammatory effects (Du et al, 2021) to improve cerebral ischemia damages, but it is unlikely to speculate from our present results that cordycepin aggravated the synaptic failure caused by OGD through A3 receptors (Pugliese et al, 2006) or A2B receptors (Fusco et al, 2018). Furthermore, activating A1R protected neurons against neurotoxicity and attenuated the memory impairments induced by ischemia-reperfusion (Ribeiro et al, 2002;Zamani et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Cordycepin Ameliorates Synaptic Dysfunction and Dendrite Morphology Damage of Hippocampal CA1 via A1R in Cerebral Ischemia

Chen

Han

Shang

et al. 2021

Front. Cell. Neurosci.

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Cordycepin exerted significant neuroprotective effects and protected against cerebral ischemic damage. Learning and memory impairments after cerebral ischemia are common. Cordycepin has been proved to improve memory impairments induced by cerebral ischemia, but its underlying mechanism has not been revealed yet. The plasticity of synaptic structure and function is considered to be one of the neural mechanisms of learning and memory. Therefore, we investigated how cordycepin benefits dendritic morphology and synaptic transmission after cerebral ischemia and traced the related molecular mechanisms. The effects of cordycepin on the protection against ischemia were studied by using global cerebral ischemia (GCI) and oxygen-glucose deprivation (OGD) models. Behavioral long-term potentiation (LTP) and synaptic transmission were observed with electrophysiological recordings. The dendritic morphology and histological assessment were assessed by Golgi staining and hematoxylin-eosin (HE) staining, respectively. Adenosine A1 receptors (A1R) and adenosine A2A receptors (A2AR) were evaluated with western blotting. The results showed that cordycepin reduced the GCI-induced dendritic morphology scathing and behavioral LTP impairment in the hippocampal CA1 area, improved the learning and memory abilities, and up-regulated the level of A1R but not A2AR. In the in vitro experiments, cordycepin pre-perfusion could alleviate the hippocampal slices injury and synaptic transmission cripple induced by OGD, accompanied by increased adenosine content. In addition, the protective effect of cordycepin on OGD-induced synaptic transmission damage was eliminated by using an A1R antagonist instead of A2AR. These findings revealed that cordycepin alleviated synaptic dysfunction and dendritic injury in ischemic models by modulating A1R, which provides new insights into the pharmacological mechanisms of cordycepin for ameliorating cognitive impairment induced by cerebral ischemia.

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Section: Discussionmentioning

confidence: 99%

Cordycepin Ameliorates Synaptic Dysfunction and Dendrite Morphology Damage of Hippocampal CA1 via A1R in Cerebral Ischemia

Chen

Han

Shang

et al. 2021

Front. Cell. Neurosci.

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“…Cordycepin has shown promise as a therapeutic agent for treating multiple inflammatory conditions, including rheumatoid arthritis [81], Parkinson's disease (PD) [82], multiple sclerosis (MS) [83], atherosclerosis [84], pneumonia [85], hepatitis [86], and atopic dermatitis (AD) [87,88]. For example, topical application of 2,4-dinitrofluorobenzene on the dorsal skin of mice induces AD-like lesions, which can be alleviated by cordycepin.…”

Section: Cordycepinmentioning

confidence: 99%

Current Progress Regarding Cordyceps militaris, Its Metabolite Function, and Its Production

Chou,

Sung,

Hou

et al. 2024

Applied Sciences

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Cordyceps militaris is a valuable medicinal fungus which has been widely used as a traditional medicine in East Asia. Compared to the well-known medicinal fungus C. sinensis, C. militaris can produce similar fermented metabolites with various biological activities, but it requires a shorter culture time and simpler culture conditions, and therefore, it has attracted increasing attention in recent years. The purpose of this review was to organize the current studies regarding metabolite production from C. militaris relative to their biological functions. We combined findings of metabolite production to correlate with different fermentation modes to obtain a full view of production processes used to yield the product. While research on C. militaris fermentation is not uncommon to date, its high value still highlights the importance of developing more modern fermentation processes for industrial production.

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“…Cordyceps sinensis , a mushroom that contains cordycepin, a derivative of the nucleoside adenosine and activator of its receptors, stimulates the production of interleukin 10, an anti-inflammatory cytokine ( 54 ). It is claimed that cordycepin products could be used as a potential medicinal adenosine receptor agonist, which could play a favorable part in the relief of COVID-19 pneumonia and the protection of the brain ( 55 ).…”

Section: Bioactive Molecules Of Mushroomsmentioning

confidence: 99%

Mushrooms as future generation healthy foods

Bell

Silva

Guina³

et al. 2022

Front. Nutr.

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The potential of edible mushrooms as an unexploited treasure trove, although rarely included in known food guidelines, is highlighted. Their role in shielding people against the side effects of an unhealthy stylish diet is reviewed. Mushrooms complement the human diet with various bioactive molecules not identified or deficient in foodstuffs of plant and animal sources, being considered a functional food for the prevention of several human diseases. Mushrooms have been widely used as medicinal products for more than 2,000 years, but globally the potential field of use of wild mushrooms has been untapped. There is a broad range of edible mushrooms which remain poorly identified or even unreported which is a valuable pool as sources of bioactive compounds for biopharma utilization and new dietary supplements. Some unique elements of mushrooms and their role in preventative healthcare are emphasized, through their positive impact on the immune system. The potential of mushrooms as antiviral, anti-inflammatory, anti-neoplastic, and other health concerns is discussed. Mushrooms incorporate top sources of non-digestible oligosaccharides, and ergothioneine, which humans are unable to synthesize, the later a unique antioxidant, cytoprotective, and anti-inflammatory element, with therapeutic potential, approved by world food agencies. The prebiotic activity of mushrooms beneficially affects gut homeostasis performance and the balance of gut microbiota is enhanced. Several recent studies on neurological impact and contribution to the growth of nerve and brain cells are mentioned. Indeed, mushrooms as functional foods' nutraceuticals are presently regarded as next-generation foods, supporting health and wellness, and are promising prophylactic or therapeutic agents.

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Interactions Between Adenosine Receptors and Cordycepin (3'- Deoxyadenosine) from Cordyceps Militaris: Possible Pharmacological Mechanisms for Protection of the Brain and the Amelioration of Covid-19 Pneumonia

Cited by 5 publications

References 0 publications

Cordycepin Ameliorates Synaptic Dysfunction and Dendrite Morphology Damage of Hippocampal CA1 via A1R in Cerebral Ischemia

Cordycepin Ameliorates Synaptic Dysfunction and Dendrite Morphology Damage of Hippocampal CA1 via A1R in Cerebral Ischemia

Current Progress Regarding Cordyceps militaris, Its Metabolite Function, and Its Production

Mushrooms as future generation healthy foods

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